Modulation of adult hippocampal neurogenesis by thyroid hormones: implications in depressive-like behavior

11 pages, 5 figures.-- PMID: 16446739.

Detalles Bibliográficos
Autores: Montero-Pedrazuela, Ana, Venero, César, Lavado Autric, Rosalía, Fernández-Lamo, Iván, García-Verdugo, José Manuel, Bernal, Juan, Guadaño-Ferraz, Ana
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2006
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/5421
Acceso en línea:http://hdl.handle.net/10261/5421
Access Level:acceso abierto
Palabra clave:Thyroid hormones
Adult neurogenesis
Dentate gyrus
Proliferation
Doublecortin
Depressive disorder
Ki-67
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spelling Modulation of adult hippocampal neurogenesis by thyroid hormones: implications in depressive-like behaviorMontero-Pedrazuela, AnaVenero, CésarLavado Autric, RosalíaFernández-Lamo, IvánGarcía-Verdugo, José ManuelBernal, JuanGuadaño-Ferraz, AnaThyroid hormonesAdult neurogenesisDentate gyrusProliferationDoublecortinDepressive disorderKi-6711 pages, 5 figures.-- PMID: 16446739.Hormonal imbalances are involved in many of the age-related pathologies, as neurodegenerative and psychiatric diseases. Specifically, thyroid state alterations in the adult are related to psychological changes and mood disorders as depression. The dentate gyrus of the hippocampal formation undergoes neurogenesis in adult mammals including humans. Recent evidence suggests that depressive disorders and their treatment are tightly related to the number of newly born neurons in the dentate gyrus.We have studied the effect of thyroid hormones (TH) on hippocampal neurogenesis in adult rats in vivo. A short period of adult-onset hypothyroidism impaired normal neurogenesis in the subgranular zone of the dentate gyrus with a 30% reduction in the number of proliferating cells. Hypothyroidism also reduced the number of newborn neuroblasts and immature neurons (doublecortin (DCX) immunopositive cells) which had a severely hypoplastic dendritic arborization. To correlate these changes with hippocampal function, we subjected the rats to the forced swimming and novel object recognition tests. Hypothyroid rats showed normal memory in object recognition, but displayed abnormal behavior in the forced swimming test, indicating a depressive-like disorder. Chronic treatment of hypothyroid rats with TH not only normalized the abnormal behavior but also restored the number of proliferative and DCX-positive cells, and induced growth of their dendritic trees. Therefore, hypothyroidism induced a reversible depressive-like disorder, which correlated to changes in neurogenesis.Our results indicate that TH are essential for adult hippocampal neurogenesis and suggest that mood disorders related to adult-onset hypothyroidism in humans could be due, in part, to impaired neurogenesis.This work was supported by Grants BFI2001-2412 and BFU2004-05944 (A.G.-F), BFI2002-00489 (J.B.), BFI2003-07524 (C.V.) from the Ministry of Science and Technology and FIS, Instituto de Salud Carlos III, Red de Centros RCMN (C03/08). A.M.-P. and I.F.-L. are recipient of a fellowship and A.G.-F. and C.V. of a contract from the Ramón y Cajal Program, all of the Ministry of Science and Technology, Spain.Peer reviewedNature Publishing GroupInstituto de Salud Carlos IIIMinisterio de Ciencia y Tecnología (España)200820082006info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersion1493353 bytesapplication/pdfhttp://hdl.handle.net/10261/5421reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1038/sj.mp.4001802info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/54212026-05-22T06:33:51Z
dc.title.none.fl_str_mv Modulation of adult hippocampal neurogenesis by thyroid hormones: implications in depressive-like behavior
title Modulation of adult hippocampal neurogenesis by thyroid hormones: implications in depressive-like behavior
spellingShingle Modulation of adult hippocampal neurogenesis by thyroid hormones: implications in depressive-like behavior
Montero-Pedrazuela, Ana
Thyroid hormones
Adult neurogenesis
Dentate gyrus
Proliferation
Doublecortin
Depressive disorder
Ki-67
title_short Modulation of adult hippocampal neurogenesis by thyroid hormones: implications in depressive-like behavior
title_full Modulation of adult hippocampal neurogenesis by thyroid hormones: implications in depressive-like behavior
title_fullStr Modulation of adult hippocampal neurogenesis by thyroid hormones: implications in depressive-like behavior
title_full_unstemmed Modulation of adult hippocampal neurogenesis by thyroid hormones: implications in depressive-like behavior
title_sort Modulation of adult hippocampal neurogenesis by thyroid hormones: implications in depressive-like behavior
dc.creator.none.fl_str_mv Montero-Pedrazuela, Ana
Venero, César
Lavado Autric, Rosalía
Fernández-Lamo, Iván
García-Verdugo, José Manuel
Bernal, Juan
Guadaño-Ferraz, Ana
author Montero-Pedrazuela, Ana
author_facet Montero-Pedrazuela, Ana
Venero, César
Lavado Autric, Rosalía
Fernández-Lamo, Iván
García-Verdugo, José Manuel
Bernal, Juan
Guadaño-Ferraz, Ana
author_role author
author2 Venero, César
Lavado Autric, Rosalía
Fernández-Lamo, Iván
García-Verdugo, José Manuel
Bernal, Juan
Guadaño-Ferraz, Ana
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
Ministerio de Ciencia y Tecnología (España)
dc.subject.none.fl_str_mv Thyroid hormones
Adult neurogenesis
Dentate gyrus
Proliferation
Doublecortin
Depressive disorder
Ki-67
topic Thyroid hormones
Adult neurogenesis
Dentate gyrus
Proliferation
Doublecortin
Depressive disorder
Ki-67
description 11 pages, 5 figures.-- PMID: 16446739.
publishDate 2006
dc.date.none.fl_str_mv 2006
2008
2008
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/5421
url http://hdl.handle.net/10261/5421
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1038/sj.mp.4001802
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1493353 bytes
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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