The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization

mRNA stability influences gene expression and translation in almost all living organisms, and the levels of mRNA molecules in the cell are determined by a balance between production and decay. Maintaining an accurate balance is crucial for the correct function of a wide variety of biological process...

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Autores: Sebastián de la Cruz, Maialen, González Moro, Itziar, Olazagoitia Garmendia, Ane, Castellanos Rubio, Ainara, Santín Gómez, Izortze
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/50824
Acceso en línea:http://hdl.handle.net/10810/50824
Access Level:acceso abierto
Palabra clave:long non-coding RNA
mRNA stability
RNA binding protein
microRNA
gene expression
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spelling The Role of lncRNAs in Gene Expression Regulation through mRNA StabilizationSebastián de la Cruz, MaialenGonzález Moro, ItziarOlazagoitia Garmendia, AneCastellanos Rubio, AinaraSantín Gómez, Izortzelong non-coding RNAmRNA stabilityRNA binding proteinmicroRNAgene expressionmRNA stability influences gene expression and translation in almost all living organisms, and the levels of mRNA molecules in the cell are determined by a balance between production and decay. Maintaining an accurate balance is crucial for the correct function of a wide variety of biological processes and to maintain an appropriate cellular homeostasis. Long non-coding RNAs (lncRNAs) have been shown to participate in the regulation of gene expression through different molecular mechanisms, including mRNA stabilization. In this review we provide an overview on the molecular mechanisms by which lncRNAs modulate mRNA stability and decay. We focus on how lncRNAs interact with RNA binding proteins and microRNAs to avoid mRNA degradation, and also on how lncRNAs modulate epitranscriptomic marks that directly impact on mRNA stability.LncRNA work in author’s laboratory is supported by European Foundation for the Study of Diabetes (EFSD)-EFSD/JDRF/Lilly Programme on Type 1 Diabetes Research and the Spanish Ministry of Science, Innovation and Universities (PID2019-104475GA-I00) to I.S; and Spanish Ministry of Science, Innovation and Universities (SAF2017-91873-EXP and PGC2018-097573-A-I00) to ACR. M.S.D. and I.G.M. are supported by a Predoctoral Fellowship Grant from the UPV/EHU (Universidad del País Vasco/Euskal Herriko Unibertsitatea) and A.O.G. is supported by a Predoctoral Fellowship Grant from the Education Department of Basque Government.MDPI2021202120212021info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/50824reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/MICINN/PID2019-104475GA-I00/info:eu-repo/grantAgreement/MICINN/SAF2017-91873-EXP/info:eu-repo/grantAgreement/MICINN/PGC2018-097573-A-I00) to/https://www.mdpi.com/2311-553X/7/1/3/htminfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).oai:addi.ehu.eus:10810/508242026-06-18T09:23:17Z
dc.title.none.fl_str_mv The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization
title The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization
spellingShingle The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization
Sebastián de la Cruz, Maialen
long non-coding RNA
mRNA stability
RNA binding protein
microRNA
gene expression
title_short The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization
title_full The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization
title_fullStr The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization
title_full_unstemmed The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization
title_sort The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization
dc.creator.none.fl_str_mv Sebastián de la Cruz, Maialen
González Moro, Itziar
Olazagoitia Garmendia, Ane
Castellanos Rubio, Ainara
Santín Gómez, Izortze
author Sebastián de la Cruz, Maialen
author_facet Sebastián de la Cruz, Maialen
González Moro, Itziar
Olazagoitia Garmendia, Ane
Castellanos Rubio, Ainara
Santín Gómez, Izortze
author_role author
author2 González Moro, Itziar
Olazagoitia Garmendia, Ane
Castellanos Rubio, Ainara
Santín Gómez, Izortze
author2_role author
author
author
author
dc.subject.none.fl_str_mv long non-coding RNA
mRNA stability
RNA binding protein
microRNA
gene expression
topic long non-coding RNA
mRNA stability
RNA binding protein
microRNA
gene expression
description mRNA stability influences gene expression and translation in almost all living organisms, and the levels of mRNA molecules in the cell are determined by a balance between production and decay. Maintaining an accurate balance is crucial for the correct function of a wide variety of biological processes and to maintain an appropriate cellular homeostasis. Long non-coding RNAs (lncRNAs) have been shown to participate in the regulation of gene expression through different molecular mechanisms, including mRNA stabilization. In this review we provide an overview on the molecular mechanisms by which lncRNAs modulate mRNA stability and decay. We focus on how lncRNAs interact with RNA binding proteins and microRNAs to avoid mRNA degradation, and also on how lncRNAs modulate epitranscriptomic marks that directly impact on mRNA stability.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/50824
url http://hdl.handle.net/10810/50824
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MICINN/PID2019-104475GA-I00/
info:eu-repo/grantAgreement/MICINN/SAF2017-91873-EXP/
info:eu-repo/grantAgreement/MICINN/PGC2018-097573-A-I00) to/
https://www.mdpi.com/2311-553X/7/1/3/htm
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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