MiR-205 is downregulated in hereditary hemorrhagic telangiectasia and impairs TGF-beta signaling pathways in endothelial cells

20 p.-6 fig.

Detalles Bibliográficos
Autores: Tabruyn, Sebastien P., Hansen, Sylvain, Ojeda-Fernández, María Luisa, Bovy, Nicolas, Zarrabeitia, Roberto, Recio-Poveda, Lucía, Bernabéu, Carmelo, Martial, Joseph A., Botella, Luisa María, Struman, Ingrid
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2013
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/100430
Acceso en línea:http://hdl.handle.net/10261/100430
Access Level:acceso abierto
Palabra clave:Hereditary hemorrhagic telangiectasia
MicroRNA
TGF-beta
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spelling MiR-205 is downregulated in hereditary hemorrhagic telangiectasia and impairs TGF-beta signaling pathways in endothelial cellsTabruyn, Sebastien P.Hansen, SylvainOjeda-Fernández, María LuisaBovy, NicolasZarrabeitia, RobertoRecio-Poveda, LucíaBernabéu, CarmeloMartial, Joseph A.Botella, Luisa MaríaStruman, IngridHereditary hemorrhagic telangiectasiaMicroRNATGF-beta20 p.-6 fig.Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder characterized by arteriovenous malformations and hemorrhages. This vascular disease results mainly from mutations in 2 genes involved in the TGF-β pathway (ENG and ALK1) that are exclusively expressed by endothelial cells. The present study identified miR-27a and miR-205 as two circulating miRNAs differentially expressed in HHT patients. The plasma levels of miR-27a are elevated while those of miR-205 are reduced in both HHT1 and HHT2 patients compared to healthy controls. The role of miR-205 in endothelial cells was further investigated. Our data indicates that miR-205 expression displaces the TGF-β balance towards the anti-angiogenic side by targeting Smad1 and Smad4. In line, overexpression of miR-205 in endothelial cells reduces proliferation, migration and tube formation while its inhibition shows opposite effects. This study not only suggests that detection of circulating miRNA (miR-27a and miR-205) could help for the screening of HHT patients but also provides a functional link between the deregulated expression of miR-205 and the HHT phenotype. © 2013 Springer Science+Business Media Dordrecht.This study was supported by the University of Liège (Fonds Speciaux), le centre anti-cancéreux (CAC ULg), the FRIA (Fonds pour la Recherche Industrielle et Agricole, Belgium), the FNRS (Fonds National de la Recherche Scientifique, Belgium), the Neoangio program #616476 of the “Service Public de Wallonie”. This work was supported by the Ministerio de Ciencia e Innovacion: Grants SAF2008–01218, SAF2011-23475, SAF2007–61827, and SAF2010–19222, and Fundación Ramón Areces of Spain (Rare and Emergent Diseases).Peer reviewedSpringer NatureConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201420142013info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/100430reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1007/s10456-013-9362-9Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1004302026-05-22T06:33:51Z
dc.title.none.fl_str_mv MiR-205 is downregulated in hereditary hemorrhagic telangiectasia and impairs TGF-beta signaling pathways in endothelial cells
title MiR-205 is downregulated in hereditary hemorrhagic telangiectasia and impairs TGF-beta signaling pathways in endothelial cells
spellingShingle MiR-205 is downregulated in hereditary hemorrhagic telangiectasia and impairs TGF-beta signaling pathways in endothelial cells
Tabruyn, Sebastien P.
Hereditary hemorrhagic telangiectasia
MicroRNA
TGF-beta
title_short MiR-205 is downregulated in hereditary hemorrhagic telangiectasia and impairs TGF-beta signaling pathways in endothelial cells
title_full MiR-205 is downregulated in hereditary hemorrhagic telangiectasia and impairs TGF-beta signaling pathways in endothelial cells
title_fullStr MiR-205 is downregulated in hereditary hemorrhagic telangiectasia and impairs TGF-beta signaling pathways in endothelial cells
title_full_unstemmed MiR-205 is downregulated in hereditary hemorrhagic telangiectasia and impairs TGF-beta signaling pathways in endothelial cells
title_sort MiR-205 is downregulated in hereditary hemorrhagic telangiectasia and impairs TGF-beta signaling pathways in endothelial cells
dc.creator.none.fl_str_mv Tabruyn, Sebastien P.
Hansen, Sylvain
Ojeda-Fernández, María Luisa
Bovy, Nicolas
Zarrabeitia, Roberto
Recio-Poveda, Lucía
Bernabéu, Carmelo
Martial, Joseph A.
Botella, Luisa María
Struman, Ingrid
author Tabruyn, Sebastien P.
author_facet Tabruyn, Sebastien P.
Hansen, Sylvain
Ojeda-Fernández, María Luisa
Bovy, Nicolas
Zarrabeitia, Roberto
Recio-Poveda, Lucía
Bernabéu, Carmelo
Martial, Joseph A.
Botella, Luisa María
Struman, Ingrid
author_role author
author2 Hansen, Sylvain
Ojeda-Fernández, María Luisa
Bovy, Nicolas
Zarrabeitia, Roberto
Recio-Poveda, Lucía
Bernabéu, Carmelo
Martial, Joseph A.
Botella, Luisa María
Struman, Ingrid
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Hereditary hemorrhagic telangiectasia
MicroRNA
TGF-beta
topic Hereditary hemorrhagic telangiectasia
MicroRNA
TGF-beta
description 20 p.-6 fig.
publishDate 2013
dc.date.none.fl_str_mv 2013
2014
2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/100430
url http://hdl.handle.net/10261/100430
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1007/s10456-013-9362-9
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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