Pulmonary embolism and 3-month outcomes in 4036 patients with venous thromboembolism and chronic obstructive pulmonary disease: data from the RIETE Registry

Background: Patients with chronic obstructive pulmonary disease (COPD) have a modified clinical presentation of venous thromboembolism (VTE) but also a worse prognosis than non-COPD patients with VTE. As it may induce therapeutic modifications, we evaluated the influence of the initial VTE presentat...

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Authors: Bertoletti, Laurent, Quenet, Sara, Laporte, Silvy, Sahuquillo, Joan Carles, Conget, Francisco, Pedrajas, José María, Martín, Mar, Casado, Ignacio, Riera Mestre, Antoni, Monreal Bosch, Manuel, RIETE investigadors
Format: article
Status:Published version
Publication Date:2013
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/126064
Online Access:https://hdl.handle.net/2445/126064
Access Level:Open access
Keyword:Embòlia pulmonar
Tromboembolisme
Pneumologia
Pronòstic mèdic
Pulmonary embolism
Thromboembolism
Pneumology
Prognosis
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spelling Pulmonary embolism and 3-month outcomes in 4036 patients with venous thromboembolism and chronic obstructive pulmonary disease: data from the RIETE RegistryBertoletti, LaurentQuenet, SaraLaporte, SilvySahuquillo, Joan CarlesConget, FranciscoPedrajas, José MaríaMartín, MarCasado, IgnacioRiera Mestre, AntoniMonreal Bosch, ManuelRIETE investigadorsEmbòlia pulmonarTromboembolismePneumologiaPronòstic mèdicPulmonary embolismThromboembolismPneumologyPrognosisBackground: Patients with chronic obstructive pulmonary disease (COPD) have a modified clinical presentation of venous thromboembolism (VTE) but also a worse prognosis than non-COPD patients with VTE. As it may induce therapeutic modifications, we evaluated the influence of the initial VTE presentation on the 3-month outcomes in COPD patients. Methods: COPD patients included in the on-going world-wide RIETE Registry were studied. The rate of pulmonary embolism (PE), major bleeding and death during the first 3 months in COPD patients were compared according to their initial clinical presentation (acute PE or deep vein thrombosis (DVT)). Results: Of the 4036 COPD patients included, 2452 (61%; 95% CI: 59.2-62.3) initially presented with PE. PE as the first VTE recurrence occurred in 116 patients, major bleeding in 101 patients and mortality in 443 patients (Fatal PE: first cause of death). Multivariate analysis confirmed that presenting with PE was associated with higher risk of VTE recurrence as PE (OR, 2.04; 95% CI: 1.11-3.72) and higher risk of fatal PE (OR, 7.77; 95% CI: 2.92-15.7). Conclusions: COPD patients presenting with PE have an increased risk for PE recurrences and fatal PE compared with those presenting with DVT alone. More efficient therapy is needed in this subtype of patients.BioMed Central2018201820132018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion9 p.application/pdfhttps://hdl.handle.net/2445/126064Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1186/1465-9921-14-75Respiratory Research, 2013, vol. 14, p. 75-83https://doi.org/10.1186/1465-9921-14-75cc-by (c) Bertoletti, Laurent et al., 2013http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1260642026-05-29T05:05:01Z
dc.title.none.fl_str_mv Pulmonary embolism and 3-month outcomes in 4036 patients with venous thromboembolism and chronic obstructive pulmonary disease: data from the RIETE Registry
title Pulmonary embolism and 3-month outcomes in 4036 patients with venous thromboembolism and chronic obstructive pulmonary disease: data from the RIETE Registry
spellingShingle Pulmonary embolism and 3-month outcomes in 4036 patients with venous thromboembolism and chronic obstructive pulmonary disease: data from the RIETE Registry
Bertoletti, Laurent
Embòlia pulmonar
Tromboembolisme
Pneumologia
Pronòstic mèdic
Pulmonary embolism
Thromboembolism
Pneumology
Prognosis
title_short Pulmonary embolism and 3-month outcomes in 4036 patients with venous thromboembolism and chronic obstructive pulmonary disease: data from the RIETE Registry
title_full Pulmonary embolism and 3-month outcomes in 4036 patients with venous thromboembolism and chronic obstructive pulmonary disease: data from the RIETE Registry
title_fullStr Pulmonary embolism and 3-month outcomes in 4036 patients with venous thromboembolism and chronic obstructive pulmonary disease: data from the RIETE Registry
title_full_unstemmed Pulmonary embolism and 3-month outcomes in 4036 patients with venous thromboembolism and chronic obstructive pulmonary disease: data from the RIETE Registry
title_sort Pulmonary embolism and 3-month outcomes in 4036 patients with venous thromboembolism and chronic obstructive pulmonary disease: data from the RIETE Registry
dc.creator.none.fl_str_mv Bertoletti, Laurent
Quenet, Sara
Laporte, Silvy
Sahuquillo, Joan Carles
Conget, Francisco
Pedrajas, José María
Martín, Mar
Casado, Ignacio
Riera Mestre, Antoni
Monreal Bosch, Manuel
RIETE investigadors
author Bertoletti, Laurent
author_facet Bertoletti, Laurent
Quenet, Sara
Laporte, Silvy
Sahuquillo, Joan Carles
Conget, Francisco
Pedrajas, José María
Martín, Mar
Casado, Ignacio
Riera Mestre, Antoni
Monreal Bosch, Manuel
RIETE investigadors
author_role author
author2 Quenet, Sara
Laporte, Silvy
Sahuquillo, Joan Carles
Conget, Francisco
Pedrajas, José María
Martín, Mar
Casado, Ignacio
Riera Mestre, Antoni
Monreal Bosch, Manuel
RIETE investigadors
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Embòlia pulmonar
Tromboembolisme
Pneumologia
Pronòstic mèdic
Pulmonary embolism
Thromboembolism
Pneumology
Prognosis
topic Embòlia pulmonar
Tromboembolisme
Pneumologia
Pronòstic mèdic
Pulmonary embolism
Thromboembolism
Pneumology
Prognosis
description Background: Patients with chronic obstructive pulmonary disease (COPD) have a modified clinical presentation of venous thromboembolism (VTE) but also a worse prognosis than non-COPD patients with VTE. As it may induce therapeutic modifications, we evaluated the influence of the initial VTE presentation on the 3-month outcomes in COPD patients. Methods: COPD patients included in the on-going world-wide RIETE Registry were studied. The rate of pulmonary embolism (PE), major bleeding and death during the first 3 months in COPD patients were compared according to their initial clinical presentation (acute PE or deep vein thrombosis (DVT)). Results: Of the 4036 COPD patients included, 2452 (61%; 95% CI: 59.2-62.3) initially presented with PE. PE as the first VTE recurrence occurred in 116 patients, major bleeding in 101 patients and mortality in 443 patients (Fatal PE: first cause of death). Multivariate analysis confirmed that presenting with PE was associated with higher risk of VTE recurrence as PE (OR, 2.04; 95% CI: 1.11-3.72) and higher risk of fatal PE (OR, 7.77; 95% CI: 2.92-15.7). Conclusions: COPD patients presenting with PE have an increased risk for PE recurrences and fatal PE compared with those presenting with DVT alone. More efficient therapy is needed in this subtype of patients.
publishDate 2013
dc.date.none.fl_str_mv 2013
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/126064
url https://hdl.handle.net/2445/126064
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1186/1465-9921-14-75
Respiratory Research, 2013, vol. 14, p. 75-83
https://doi.org/10.1186/1465-9921-14-75
dc.rights.none.fl_str_mv cc-by (c) Bertoletti, Laurent et al., 2013
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Bertoletti, Laurent et al., 2013
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9 p.
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869424815193980928
score 15,811543

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