Longitudinal associations between cardiovascular biomarkers and metabolic syndrome during puberty: the PUBMEP study

Puberty has been described as a life stage of considerable metabolic risk specially for those with obesity. The low-grade systemic inflammatory status associated with obesity could be one of the connections with metabolic syndrome (MetS). Thus, we aimed to assess the relationship between inflammator...

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Autores: González-Gil, Esther M., Anguita-Ruiz, Augusto, Kalén, Anton, De las Lamas Perez, Carmela, Rupérez, Azahara I., Vázquez-Cobela, Rocio, Flores, Katherine, Gil, Angel, Gil-Campos, Mercedes, Bueno, Gloria, Leis, Rosaura, Aguilera, Concepción M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Zaragoza
Repositorio:Zaguán. Repositorio Digital de la Universidad de Zaragoza
OAI Identifier:oai:zaguan.unizar.es:120197
Acceso en línea:http://zaguan.unizar.es/record/120197
Access Level:acceso abierto
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spelling Longitudinal associations between cardiovascular biomarkers and metabolic syndrome during puberty: the PUBMEP studyGonzález-Gil, Esther M.Anguita-Ruiz, AugustoKalén, AntonDe las Lamas Perez, CarmelaRupérez, Azahara I.Vázquez-Cobela, RocioFlores, KatherineGil, AngelGil-Campos, MercedesBueno, GloriaLeis, RosauraAguilera, Concepción M.Puberty has been described as a life stage of considerable metabolic risk specially for those with obesity. The low-grade systemic inflammatory status associated with obesity could be one of the connections with metabolic syndrome (MetS). Thus, we aimed to assess the relationship between inflammatory and cardiovascular biomarkers and the development of MetS during puberty. Seventy-five children from the PUBMEP study (33 females), aged 4–18 years, were included. Cardiovascular and inflammatory biomarkers were measured in the prepubertal and pubertal stage, including high-sensitivity C-reactive protein (CRP), leptin, tumor necrosis factor-alpha (TNFα), interleukin 8 (IL8), monocyte chemoattractant protein 1 (MCP-1), total plasminogen activator inhibitor-1 (tPAI), resistin, adiponectin, myeloperoxidase (MPO), and soluble intercellular adhesion molecule-1 (sICAM-1). MetS was diagnosed at each measurement point. Mixed-effects and logistic regressions were performed. Those children with MetS in puberty presented higher prepubertal values of several cardiometabolic biomarkers in comparison to those without MetS (z-score body mass index (zBMI), waist circumference, insulin, HOMA-IR, leptin, and tPAI (p < 0.05)). For prepubertal children with obesity, the odds of developing MetS in puberty were significantly higher in those having high zBMI (OR = 4.27; CI: 1.39–22.59) or high concentrations of tPAI (OR = 1.19; CI: 1.06–1.43)2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://zaguan.unizar.es/record/120197reponame:Zaguán. Repositorio Digital de la Universidad de Zaragozainstname:Universidad de ZaragozaInglésinfo:eu-repo/grantAgreement/ES/CIBERObn/CB15-00043info:eu-repo/grantAgreement/ES/CIBERObn/CB15-00131info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-01425info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-02042info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-02059info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-00871info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-01205info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-01301info:eu-repo/grantAgreement/ES/ISCIII/FISinfo:eu-repo/semantics/openAccessoai:zaguan.unizar.es:1201972026-05-29T13:59:51Z
dc.title.none.fl_str_mv Longitudinal associations between cardiovascular biomarkers and metabolic syndrome during puberty: the PUBMEP study
title Longitudinal associations between cardiovascular biomarkers and metabolic syndrome during puberty: the PUBMEP study
spellingShingle Longitudinal associations between cardiovascular biomarkers and metabolic syndrome during puberty: the PUBMEP study
González-Gil, Esther M.
title_short Longitudinal associations between cardiovascular biomarkers and metabolic syndrome during puberty: the PUBMEP study
title_full Longitudinal associations between cardiovascular biomarkers and metabolic syndrome during puberty: the PUBMEP study
title_fullStr Longitudinal associations between cardiovascular biomarkers and metabolic syndrome during puberty: the PUBMEP study
title_full_unstemmed Longitudinal associations between cardiovascular biomarkers and metabolic syndrome during puberty: the PUBMEP study
title_sort Longitudinal associations between cardiovascular biomarkers and metabolic syndrome during puberty: the PUBMEP study
dc.creator.none.fl_str_mv González-Gil, Esther M.
Anguita-Ruiz, Augusto
Kalén, Anton
De las Lamas Perez, Carmela
Rupérez, Azahara I.
Vázquez-Cobela, Rocio
Flores, Katherine
Gil, Angel
Gil-Campos, Mercedes
Bueno, Gloria
Leis, Rosaura
Aguilera, Concepción M.
author González-Gil, Esther M.
author_facet González-Gil, Esther M.
Anguita-Ruiz, Augusto
Kalén, Anton
De las Lamas Perez, Carmela
Rupérez, Azahara I.
Vázquez-Cobela, Rocio
Flores, Katherine
Gil, Angel
Gil-Campos, Mercedes
Bueno, Gloria
Leis, Rosaura
Aguilera, Concepción M.
author_role author
author2 Anguita-Ruiz, Augusto
Kalén, Anton
De las Lamas Perez, Carmela
Rupérez, Azahara I.
Vázquez-Cobela, Rocio
Flores, Katherine
Gil, Angel
Gil-Campos, Mercedes
Bueno, Gloria
Leis, Rosaura
Aguilera, Concepción M.
author2_role author
author
author
author
author
author
author
author
author
author
author
description Puberty has been described as a life stage of considerable metabolic risk specially for those with obesity. The low-grade systemic inflammatory status associated with obesity could be one of the connections with metabolic syndrome (MetS). Thus, we aimed to assess the relationship between inflammatory and cardiovascular biomarkers and the development of MetS during puberty. Seventy-five children from the PUBMEP study (33 females), aged 4–18 years, were included. Cardiovascular and inflammatory biomarkers were measured in the prepubertal and pubertal stage, including high-sensitivity C-reactive protein (CRP), leptin, tumor necrosis factor-alpha (TNFα), interleukin 8 (IL8), monocyte chemoattractant protein 1 (MCP-1), total plasminogen activator inhibitor-1 (tPAI), resistin, adiponectin, myeloperoxidase (MPO), and soluble intercellular adhesion molecule-1 (sICAM-1). MetS was diagnosed at each measurement point. Mixed-effects and logistic regressions were performed. Those children with MetS in puberty presented higher prepubertal values of several cardiometabolic biomarkers in comparison to those without MetS (z-score body mass index (zBMI), waist circumference, insulin, HOMA-IR, leptin, and tPAI (p < 0.05)). For prepubertal children with obesity, the odds of developing MetS in puberty were significantly higher in those having high zBMI (OR = 4.27; CI: 1.39–22.59) or high concentrations of tPAI (OR = 1.19; CI: 1.06–1.43)
publishDate 2023
dc.date.none.fl_str_mv 2023
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dc.identifier.none.fl_str_mv http://zaguan.unizar.es/record/120197
url http://zaguan.unizar.es/record/120197
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
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info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-02042
info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-02059
info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-00871
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dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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publisher.none.fl_str_mv
dc.source.none.fl_str_mv reponame:Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname:Universidad de Zaragoza
instname_str Universidad de Zaragoza
reponame_str Zaguán. Repositorio Digital de la Universidad de Zaragoza
collection Zaguán. Repositorio Digital de la Universidad de Zaragoza
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