Reproducibility of measurement of myometrial invasion in endometrial carcinoma

Myometrial invasion (MI) as a percentage (%MI), categorized into <50 or ≥50 %, is an important predictor of prognosis in endometrial carcinoma. Recent studies suggest that tumor-free distance (TFD) to serosa and the absolute depth of invasion (DOI) might be stronger predictors of prognosis. Altho...

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Autores: van der Putten, Louis J. M., van de Vijver, Koen, Bartosch, Carla, Davidson, Ben, Gatius Calderó, Sònia, Matias-Guiu, Xavier, McCluggage, W. Glenn, Toledo, Gemma, van der Wurff, Anneke A. M., Pijnenborg, Johanna M. A., Massuger, Leon F. A. G., Bulten, Johan
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/58578
Acesso em linha:https://doi.org/10.1007/s00428-016-2035-5
http://hdl.handle.net/10459.1/58578
Access Level:acceso abierto
Palavra-chave:Endometrial carcinoma
Myometrial invasion
Depth of invasion
Tumor-free distance
Inter-observer variability
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spelling Reproducibility of measurement of myometrial invasion in endometrial carcinomavan der Putten, Louis J. M.van de Vijver, KoenBartosch, CarlaDavidson, BenGatius Calderó, SòniaMatias-Guiu, XavierMcCluggage, W. GlennToledo, Gemmavan der Wurff, Anneke A. M.Pijnenborg, Johanna M. A.Massuger, Leon F. A. G.Bulten, JohanEndometrial carcinomaMyometrial invasionDepth of invasionTumor-free distanceInter-observer variabilityMyometrial invasion (MI) as a percentage (%MI), categorized into <50 or ≥50 %, is an important predictor of prognosis in endometrial carcinoma. Recent studies suggest that tumor-free distance (TFD) to serosa and the absolute depth of invasion (DOI) might be stronger predictors of prognosis. Although reproducibility is important in clinical practice for patient prognostication and treatment, reproducibility of these methods for the measurement of MI is largely unknown. One or two slides from 50 patients with FIGO stage I endometrioid endometrial carcinoma were viewed by seven gynecological pathologists, who were requested to measure %MI, TFD, and DOI. We categorized %MI as <50 % (including no MI) or ≥50 %, TFD as ≤1.75 or >1.75 mm (including no MI), ≤7 or >7 mm (including no MI), and ≤10 or >10 mm (including no MI) and DOI as <4 mm (including no MI) or ≥4 mm. Light’s kappa for multi-rater agreement was calculated. The %MI, TFD, and DOI could be measured in 88, 83, and 79 % of cases, respectively. Kappa was 0.75 for %MI, 0.77, 0.73, and 0.69 respectively for TFD with cutoffs of 1.75, 7, and 10 mm, and 0.59 for DOI. Pathologists reach substantial agreement when measuring %MI and TFD and moderate agreement when measuring DOI. The %MI can be measured in more cases than TFD and DOI. This supports the use of %MI in daily clinical practice, but future studies should compare %MI and TFD more extensively, including inter-observer variability.Springer Berlin Heidelberg2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1007/s00428-016-2035-5http://hdl.handle.net/10459.1/58578reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a https://doi.org/10.1007/s00428-016-2035-5Virchows Archiv, 2016, p. 1-6cc-by (c) van der Putten, Louis J. M., et al. 2016info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/oai:recercat.cat:10459.1/585782026-05-29T05:05:01Z
dc.title.none.fl_str_mv Reproducibility of measurement of myometrial invasion in endometrial carcinoma
title Reproducibility of measurement of myometrial invasion in endometrial carcinoma
spellingShingle Reproducibility of measurement of myometrial invasion in endometrial carcinoma
van der Putten, Louis J. M.
Endometrial carcinoma
Myometrial invasion
Depth of invasion
Tumor-free distance
Inter-observer variability
title_short Reproducibility of measurement of myometrial invasion in endometrial carcinoma
title_full Reproducibility of measurement of myometrial invasion in endometrial carcinoma
title_fullStr Reproducibility of measurement of myometrial invasion in endometrial carcinoma
title_full_unstemmed Reproducibility of measurement of myometrial invasion in endometrial carcinoma
title_sort Reproducibility of measurement of myometrial invasion in endometrial carcinoma
dc.creator.none.fl_str_mv van der Putten, Louis J. M.
van de Vijver, Koen
Bartosch, Carla
Davidson, Ben
Gatius Calderó, Sònia
Matias-Guiu, Xavier
McCluggage, W. Glenn
Toledo, Gemma
van der Wurff, Anneke A. M.
Pijnenborg, Johanna M. A.
Massuger, Leon F. A. G.
Bulten, Johan
author van der Putten, Louis J. M.
author_facet van der Putten, Louis J. M.
van de Vijver, Koen
Bartosch, Carla
Davidson, Ben
Gatius Calderó, Sònia
Matias-Guiu, Xavier
McCluggage, W. Glenn
Toledo, Gemma
van der Wurff, Anneke A. M.
Pijnenborg, Johanna M. A.
Massuger, Leon F. A. G.
Bulten, Johan
author_role author
author2 van de Vijver, Koen
Bartosch, Carla
Davidson, Ben
Gatius Calderó, Sònia
Matias-Guiu, Xavier
McCluggage, W. Glenn
Toledo, Gemma
van der Wurff, Anneke A. M.
Pijnenborg, Johanna M. A.
Massuger, Leon F. A. G.
Bulten, Johan
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Endometrial carcinoma
Myometrial invasion
Depth of invasion
Tumor-free distance
Inter-observer variability
topic Endometrial carcinoma
Myometrial invasion
Depth of invasion
Tumor-free distance
Inter-observer variability
description Myometrial invasion (MI) as a percentage (%MI), categorized into <50 or ≥50 %, is an important predictor of prognosis in endometrial carcinoma. Recent studies suggest that tumor-free distance (TFD) to serosa and the absolute depth of invasion (DOI) might be stronger predictors of prognosis. Although reproducibility is important in clinical practice for patient prognostication and treatment, reproducibility of these methods for the measurement of MI is largely unknown. One or two slides from 50 patients with FIGO stage I endometrioid endometrial carcinoma were viewed by seven gynecological pathologists, who were requested to measure %MI, TFD, and DOI. We categorized %MI as <50 % (including no MI) or ≥50 %, TFD as ≤1.75 or >1.75 mm (including no MI), ≤7 or >7 mm (including no MI), and ≤10 or >10 mm (including no MI) and DOI as <4 mm (including no MI) or ≥4 mm. Light’s kappa for multi-rater agreement was calculated. The %MI, TFD, and DOI could be measured in 88, 83, and 79 % of cases, respectively. Kappa was 0.75 for %MI, 0.77, 0.73, and 0.69 respectively for TFD with cutoffs of 1.75, 7, and 10 mm, and 0.59 for DOI. Pathologists reach substantial agreement when measuring %MI and TFD and moderate agreement when measuring DOI. The %MI can be measured in more cases than TFD and DOI. This supports the use of %MI in daily clinical practice, but future studies should compare %MI and TFD more extensively, including inter-observer variability.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1007/s00428-016-2035-5
http://hdl.handle.net/10459.1/58578
url https://doi.org/10.1007/s00428-016-2035-5
http://hdl.handle.net/10459.1/58578
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.1007/s00428-016-2035-5
Virchows Archiv, 2016, p. 1-6
dc.rights.none.fl_str_mv cc-by (c) van der Putten, Louis J. M., et al. 2016
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
rights_invalid_str_mv cc-by (c) van der Putten, Louis J. M., et al. 2016
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Berlin Heidelberg
publisher.none.fl_str_mv Springer Berlin Heidelberg
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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