The synergetic effect of childhood trauma and recent stressful events in psychosis: associated neurocognitive dysfunction

Background A higher incidence of childhood trauma (CT) has been reported in first episode of psychosis (FEP). There is, however, a lack of knowledge about the synergetic effect between CT and recent stressful events (RSE). Methods Information on specific types of CT (under 17 years) and RSE (within...

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Autores: Ayesa Arriola, Rosa, Setien Suero, Esther, Marques-Feixa, Laia, Neergaard, Karl, Butjosa, A., Vázquez-Bourgon, J., Fañanás Saura, Lourdes, Crespo Facorro, Benedicto
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/173141
Acceso en línea:https://hdl.handle.net/2445/173141
Access Level:acceso abierto
Palabra clave:Traumes psíquics
Malalties mentals
Infants
Psychic trauma
Mental illness
Children
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spelling The synergetic effect of childhood trauma and recent stressful events in psychosis: associated neurocognitive dysfunctionAyesa Arriola, RosaSetien Suero, EstherMarques-Feixa, LaiaNeergaard, KarlButjosa, A.Vázquez-Bourgon, J.Fañanás Saura, LourdesCrespo Facorro, BenedictoTraumes psíquicsMalalties mentalsInfantsPsychic traumaMental illnessChildrenBackground A higher incidence of childhood trauma (CT) has been reported in first episode of psychosis (FEP). There is, however, a lack of knowledge about the synergetic effect between CT and recent stressful events (RSE). Methods Information on specific types of CT (under 17 years) and RSE (within the past 3 years) was available for 290 FEP patients and 52 healthy controls (HC). Cognitive function at baseline was assessed through a comprehensive neuropsychological test battery. Results While 45.2% of FEP patients and 25% of HC reported at least one CT event, 62.7% of FEP and 21.2% of HC reported an RSE. Meanwhile, 36.2% of FEP patients and 9.6% of HC encountered both childhood and recent stressful events. The patients that just reported CT showed normality in all but the verbal memory cognitive domain; those with additive CT and RSE presented worse general cognitive function, specifically on working memory, processing speed, and executive function. RSE and general cognitive dysfunction were significant determinants of psychosis onset. Conclusions These results support a synergetic influence of trauma and stressful events on brain function and allow a better understanding of mediators for psychotic disorders useful in the design of specific strategies based on stress‐targeted therapies.John Wiley & Sons2021202120192021info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion9 p.application/pdfhttps://hdl.handle.net/2445/173141Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1111/acps.13114Acta Psychiatrica Scandinavica, 2019, vol. 141, num. 1, p. 43-51https://doi.org/10.1111/acps.13114(c) John Wiley & Sons, 2019info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1731412026-05-29T05:05:01Z
dc.title.none.fl_str_mv The synergetic effect of childhood trauma and recent stressful events in psychosis: associated neurocognitive dysfunction
title The synergetic effect of childhood trauma and recent stressful events in psychosis: associated neurocognitive dysfunction
spellingShingle The synergetic effect of childhood trauma and recent stressful events in psychosis: associated neurocognitive dysfunction
Ayesa Arriola, Rosa
Traumes psíquics
Malalties mentals
Infants
Psychic trauma
Mental illness
Children
title_short The synergetic effect of childhood trauma and recent stressful events in psychosis: associated neurocognitive dysfunction
title_full The synergetic effect of childhood trauma and recent stressful events in psychosis: associated neurocognitive dysfunction
title_fullStr The synergetic effect of childhood trauma and recent stressful events in psychosis: associated neurocognitive dysfunction
title_full_unstemmed The synergetic effect of childhood trauma and recent stressful events in psychosis: associated neurocognitive dysfunction
title_sort The synergetic effect of childhood trauma and recent stressful events in psychosis: associated neurocognitive dysfunction
dc.creator.none.fl_str_mv Ayesa Arriola, Rosa
Setien Suero, Esther
Marques-Feixa, Laia
Neergaard, Karl
Butjosa, A.
Vázquez-Bourgon, J.
Fañanás Saura, Lourdes
Crespo Facorro, Benedicto
author Ayesa Arriola, Rosa
author_facet Ayesa Arriola, Rosa
Setien Suero, Esther
Marques-Feixa, Laia
Neergaard, Karl
Butjosa, A.
Vázquez-Bourgon, J.
Fañanás Saura, Lourdes
Crespo Facorro, Benedicto
author_role author
author2 Setien Suero, Esther
Marques-Feixa, Laia
Neergaard, Karl
Butjosa, A.
Vázquez-Bourgon, J.
Fañanás Saura, Lourdes
Crespo Facorro, Benedicto
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Traumes psíquics
Malalties mentals
Infants
Psychic trauma
Mental illness
Children
topic Traumes psíquics
Malalties mentals
Infants
Psychic trauma
Mental illness
Children
description Background A higher incidence of childhood trauma (CT) has been reported in first episode of psychosis (FEP). There is, however, a lack of knowledge about the synergetic effect between CT and recent stressful events (RSE). Methods Information on specific types of CT (under 17 years) and RSE (within the past 3 years) was available for 290 FEP patients and 52 healthy controls (HC). Cognitive function at baseline was assessed through a comprehensive neuropsychological test battery. Results While 45.2% of FEP patients and 25% of HC reported at least one CT event, 62.7% of FEP and 21.2% of HC reported an RSE. Meanwhile, 36.2% of FEP patients and 9.6% of HC encountered both childhood and recent stressful events. The patients that just reported CT showed normality in all but the verbal memory cognitive domain; those with additive CT and RSE presented worse general cognitive function, specifically on working memory, processing speed, and executive function. RSE and general cognitive dysfunction were significant determinants of psychosis onset. Conclusions These results support a synergetic influence of trauma and stressful events on brain function and allow a better understanding of mediators for psychotic disorders useful in the design of specific strategies based on stress‐targeted therapies.
publishDate 2019
dc.date.none.fl_str_mv 2019
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/173141
url https://hdl.handle.net/2445/173141
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1111/acps.13114
Acta Psychiatrica Scandinavica, 2019, vol. 141, num. 1, p. 43-51
https://doi.org/10.1111/acps.13114
dc.rights.none.fl_str_mv (c) John Wiley & Sons, 2019
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) John Wiley & Sons, 2019
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9 p.
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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