Comparison of rapid and same-day desensitization protocols in hypersensitivity reactions to platinum and taxanes: a retrospective cohort study

Background Rapid drug desensitization (RDD) allows first-line treatment to continue after a hypersensitivity reaction to the antineoplastic agent. There are different desensitization procedures, and none of them are free from breakthrough reactions (BTR).Objectives The objective of the study is to e...

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Autores: Górriz, MCT, Cuartero, JB, Ayllón, PV, Hernández, AS, Hernández, CV, Viciano, IG, Enrique, E
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:Universidad de Málaga
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:dnet:r-fisabio___::165370c97d3f65d9e954062969a78826
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/20548
Access Level:acceso abierto
Palabra clave:antineoplastic agents
breakthrough reactions
chemotherapy
rapid drug desensitization
same day desensitization
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spelling Comparison of rapid and same-day desensitization protocols in hypersensitivity reactions to platinum and taxanes: a retrospective cohort studyGórriz, MCTCuartero, JBAyllón, PVHernández, ASHernández, CVViciano, IGEnrique, Eantineoplastic agentsbreakthrough reactionschemotherapyrapid drug desensitizationsame day desensitizationBackground Rapid drug desensitization (RDD) allows first-line treatment to continue after a hypersensitivity reaction to the antineoplastic agent. There are different desensitization procedures, and none of them are free from breakthrough reactions (BTR).Objectives The objective of the study is to evaluate and compare the efficacy of different desensitization procedures, considering the effect of a series of confounding variables, and to describe the characteristics of BTRs in different procedures.Methods A retrospective, comparative review of medical records from patients who experienced hypersensitivity reactions to platinum- or taxane-based chemotherapy was conducted. Patients were categorized into two groups; rapid drug desensitization (RDD) and same-day desensitization (SDD), according to the intervention performed on the day of the initial reaction. Demographic data, drug, retreatment, cancer type, phenotype and severity of the initial reaction, allergy testing, number of desensitizations performed, outcome of desensitizations, and number, phenotype and severity of BTRs were recorded according to group.Results In the RDD group, 406 desensitizations were analyzed in 76 subjects with a BTR rate of 24%. In the SDD group, 164 desensitizations were analyzed in 44 subjects with a BTR rate of 15%. A marginaleffects analysis using a Bayesian hierarchical model showed a 14.6-point reduction in the probability of BTR in the SDD group.Conclusion This study confirms that desensitization procedures are safe and effective and allows us to conclude, based on the data and the model, that the SDD group has a lower probability of BTR than the RDD group.FRONTIERS MEDIA SA2026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/20548Frontiers in AllergyISSN: 26736101reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Universidad de MálagaInglésinfo:eu-repo/semantics/openAccessoai:dnet:r-fisabio___::165370c97d3f65d9e954062969a788262026-06-11T12:45:17Z
dc.title.none.fl_str_mv Comparison of rapid and same-day desensitization protocols in hypersensitivity reactions to platinum and taxanes: a retrospective cohort study
title Comparison of rapid and same-day desensitization protocols in hypersensitivity reactions to platinum and taxanes: a retrospective cohort study
spellingShingle Comparison of rapid and same-day desensitization protocols in hypersensitivity reactions to platinum and taxanes: a retrospective cohort study
Górriz, MCT
antineoplastic agents
breakthrough reactions
chemotherapy
rapid drug desensitization
same day desensitization
title_short Comparison of rapid and same-day desensitization protocols in hypersensitivity reactions to platinum and taxanes: a retrospective cohort study
title_full Comparison of rapid and same-day desensitization protocols in hypersensitivity reactions to platinum and taxanes: a retrospective cohort study
title_fullStr Comparison of rapid and same-day desensitization protocols in hypersensitivity reactions to platinum and taxanes: a retrospective cohort study
title_full_unstemmed Comparison of rapid and same-day desensitization protocols in hypersensitivity reactions to platinum and taxanes: a retrospective cohort study
title_sort Comparison of rapid and same-day desensitization protocols in hypersensitivity reactions to platinum and taxanes: a retrospective cohort study
dc.creator.none.fl_str_mv Górriz, MCT
Cuartero, JB
Ayllón, PV
Hernández, AS
Hernández, CV
Viciano, IG
Enrique, E
author Górriz, MCT
author_facet Górriz, MCT
Cuartero, JB
Ayllón, PV
Hernández, AS
Hernández, CV
Viciano, IG
Enrique, E
author_role author
author2 Cuartero, JB
Ayllón, PV
Hernández, AS
Hernández, CV
Viciano, IG
Enrique, E
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv antineoplastic agents
breakthrough reactions
chemotherapy
rapid drug desensitization
same day desensitization
topic antineoplastic agents
breakthrough reactions
chemotherapy
rapid drug desensitization
same day desensitization
description Background Rapid drug desensitization (RDD) allows first-line treatment to continue after a hypersensitivity reaction to the antineoplastic agent. There are different desensitization procedures, and none of them are free from breakthrough reactions (BTR).Objectives The objective of the study is to evaluate and compare the efficacy of different desensitization procedures, considering the effect of a series of confounding variables, and to describe the characteristics of BTRs in different procedures.Methods A retrospective, comparative review of medical records from patients who experienced hypersensitivity reactions to platinum- or taxane-based chemotherapy was conducted. Patients were categorized into two groups; rapid drug desensitization (RDD) and same-day desensitization (SDD), according to the intervention performed on the day of the initial reaction. Demographic data, drug, retreatment, cancer type, phenotype and severity of the initial reaction, allergy testing, number of desensitizations performed, outcome of desensitizations, and number, phenotype and severity of BTRs were recorded according to group.Results In the RDD group, 406 desensitizations were analyzed in 76 subjects with a BTR rate of 24%. In the SDD group, 164 desensitizations were analyzed in 44 subjects with a BTR rate of 15%. A marginaleffects analysis using a Bayesian hierarchical model showed a 14.6-point reduction in the probability of BTR in the SDD group.Conclusion This study confirms that desensitization procedures are safe and effective and allows us to conclude, based on the data and the model, that the SDD group has a lower probability of BTR than the RDD group.
publishDate 2026
dc.date.none.fl_str_mv 2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/20548
url https://fisabio.portalinvestigacion.com/publicaciones/20548
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv FRONTIERS MEDIA SA
publisher.none.fl_str_mv FRONTIERS MEDIA SA
dc.source.none.fl_str_mv Frontiers in Allergy
ISSN: 26736101
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Universidad de Málaga
instname_str Universidad de Málaga
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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