Bioengineered in vitro skeletal muscles as new tools for muscular dystrophies preclinical studies

Muscular dystrophies are a group of highly disabling disorders that share degenerative muscle weakness and wasting as common symptoms. To date, there is not an effective cure for these diseases. In the last years, bioengineered tissues have emerged as powerful tools for preclinical studies. In this...

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Autores: Fernández Costa, Juan M., Fernández Garibay, Xiomara, Velasco Mallorquí, Ferran, Ramón Azcón, Javier
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/179130
Acceso en línea:https://hdl.handle.net/2445/179130
Access Level:acceso abierto
Palabra clave:Materials biomèdics
Enginyeria de teixits
Distròfia muscular
Biomedical materials
Tissue engineering
Muscular dystrophy
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spelling Bioengineered in vitro skeletal muscles as new tools for muscular dystrophies preclinical studiesFernández Costa, Juan M.Fernández Garibay, XiomaraVelasco Mallorquí, FerranRamón Azcón, JavierMaterials biomèdicsEnginyeria de teixitsDistròfia muscularBiomedical materialsTissue engineeringMuscular dystrophyMuscular dystrophies are a group of highly disabling disorders that share degenerative muscle weakness and wasting as common symptoms. To date, there is not an effective cure for these diseases. In the last years, bioengineered tissues have emerged as powerful tools for preclinical studies. In this review, we summarize the recent technological advances in skeletal muscle tissue engineering. We identify several ground-breaking techniques to fabricate in vitro bioartificial muscles. Accumulating evidence shows that scaffold-based tissue engineering provides topographical cues that enhance the viability and maturation of skeletal muscle. Functional bioartificial muscles have been developed using human myoblasts. These tissues accurately responded to electrical and biological stimulation. Moreover, advanced drug screening tools can be fabricated integrating these tissues in electrical stimulation platforms. However, more work introducing patient-derived cells and integrating these tissues in microdevices is needed to promote the clinical translation of bioengineered skeletal muscle as preclinical tools for muscular dystrophies.SAGE journals2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/179130Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1177/2041731420981339Journal of Tissue Engineering, 2021, vol. 12https://doi.org/10.1177/2041731420981339info:eu-repo/grantAgreement/EC/H2020/714317cc by-nc-nd (c) Fernández Costa, Juan M. et al., 2021http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1791302026-05-27T06:46:51Z
dc.title.none.fl_str_mv Bioengineered in vitro skeletal muscles as new tools for muscular dystrophies preclinical studies
title Bioengineered in vitro skeletal muscles as new tools for muscular dystrophies preclinical studies
spellingShingle Bioengineered in vitro skeletal muscles as new tools for muscular dystrophies preclinical studies
Fernández Costa, Juan M.
Materials biomèdics
Enginyeria de teixits
Distròfia muscular
Biomedical materials
Tissue engineering
Muscular dystrophy
title_short Bioengineered in vitro skeletal muscles as new tools for muscular dystrophies preclinical studies
title_full Bioengineered in vitro skeletal muscles as new tools for muscular dystrophies preclinical studies
title_fullStr Bioengineered in vitro skeletal muscles as new tools for muscular dystrophies preclinical studies
title_full_unstemmed Bioengineered in vitro skeletal muscles as new tools for muscular dystrophies preclinical studies
title_sort Bioengineered in vitro skeletal muscles as new tools for muscular dystrophies preclinical studies
dc.creator.none.fl_str_mv Fernández Costa, Juan M.
Fernández Garibay, Xiomara
Velasco Mallorquí, Ferran
Ramón Azcón, Javier
author Fernández Costa, Juan M.
author_facet Fernández Costa, Juan M.
Fernández Garibay, Xiomara
Velasco Mallorquí, Ferran
Ramón Azcón, Javier
author_role author
author2 Fernández Garibay, Xiomara
Velasco Mallorquí, Ferran
Ramón Azcón, Javier
author2_role author
author
author
dc.subject.none.fl_str_mv Materials biomèdics
Enginyeria de teixits
Distròfia muscular
Biomedical materials
Tissue engineering
Muscular dystrophy
topic Materials biomèdics
Enginyeria de teixits
Distròfia muscular
Biomedical materials
Tissue engineering
Muscular dystrophy
description Muscular dystrophies are a group of highly disabling disorders that share degenerative muscle weakness and wasting as common symptoms. To date, there is not an effective cure for these diseases. In the last years, bioengineered tissues have emerged as powerful tools for preclinical studies. In this review, we summarize the recent technological advances in skeletal muscle tissue engineering. We identify several ground-breaking techniques to fabricate in vitro bioartificial muscles. Accumulating evidence shows that scaffold-based tissue engineering provides topographical cues that enhance the viability and maturation of skeletal muscle. Functional bioartificial muscles have been developed using human myoblasts. These tissues accurately responded to electrical and biological stimulation. Moreover, advanced drug screening tools can be fabricated integrating these tissues in electrical stimulation platforms. However, more work introducing patient-derived cells and integrating these tissues in microdevices is needed to promote the clinical translation of bioengineered skeletal muscle as preclinical tools for muscular dystrophies.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/179130
url https://hdl.handle.net/2445/179130
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1177/2041731420981339
Journal of Tissue Engineering, 2021, vol. 12
https://doi.org/10.1177/2041731420981339
info:eu-repo/grantAgreement/EC/H2020/714317
dc.rights.none.fl_str_mv cc by-nc-nd (c) Fernández Costa, Juan M. et al., 2021
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Fernández Costa, Juan M. et al., 2021
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv SAGE journals
publisher.none.fl_str_mv SAGE journals
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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