Metal-based nanoparticles in cancer therapy: Exploring photodynamic therapy and its interplay with regulated cell death pathways

Photodynamic therapy (PDT) represents a non-invasive treatment strategy currently utilized in the clinical management of selected cancers and infections. This technique is predicated on the administration of a photosensitizer (PS) and subsequent irradiation with light of specific wavelengths, thereb...

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Authors: Pashootan, Parya, Saadati, Fatemeh, Fahimi, Hossein, Rahmati, Marveh, Strippoli, Raffaele, Zarrabi, Ali, Cordani, Marco, Moosavi, Mohammad Amin
Format: article
Publication Date:2023
Country:España
Institution:Universidad Complutense de Madrid (UCM)
Repository:Docta Complutense
Language:English
OAI Identifier:oai:docta.ucm.es:20.500.14352/92909
Online Access:https://hdl.handle.net/20.500.14352/92909
Access Level:Open access
Keyword:577.1
616-006.04
Apoptosis
Autophagy Immunogenic cell death
Metallic nanoparticles
Photodynamic therapy
Regulated cell death
Biología celular (Biología)
Bioquímica (Farmacia)
Oncología
2407 Biología Celular
2302 Bioquímica
3201.01 Oncología
id ES_f69d4836ab35e2baddcfb5aa2d260eb1
oai_identifier_str oai:docta.ucm.es:20.500.14352/92909
network_acronym_str ES
network_name_str España
repository_id_str
spelling Metal-based nanoparticles in cancer therapy: Exploring photodynamic therapy and its interplay with regulated cell death pathwaysPashootan, ParyaSaadati, FatemehFahimi, HosseinRahmati, MarvehStrippoli, RaffaeleZarrabi, AliCordani, MarcoMoosavi, Mohammad Amin577.1616-006.04ApoptosisAutophagy Immunogenic cell deathMetallic nanoparticlesPhotodynamic therapyRegulated cell deathBiología celular (Biología)Bioquímica (Farmacia)Oncología2407 Biología Celular2302 Bioquímica3201.01 OncologíaPhotodynamic therapy (PDT) represents a non-invasive treatment strategy currently utilized in the clinical management of selected cancers and infections. This technique is predicated on the administration of a photosensitizer (PS) and subsequent irradiation with light of specific wavelengths, thereby generating reactive oxygen species (ROS) within targeted cells. The cellular effects of PDT are dependent on both the localization of the PS and the severity of ROS challenge, potentially leading to the stimulation of various cell death modalities. For many years, the concept of regulated cell death (RCD) triggered by photodynamic reactions predominantly encompassed apoptosis, necrosis, and autophagy. However, in recent decades, further explorations have unveiled additional cell death modalities, such as necroptosis, ferroptosis, cuproptosis, pyroptosis, parthanatos, and immunogenic cell death (ICD), which helps to achieve tumor cell elimination. Recently, nanoparticles (NPs) have demonstrated substantial advantages over traditional PSs and become important components of PDT, due to their improved physicochemical properties, such as enhanced solubility and superior specificity for targeted cells. This review aims to summarize recent advancements in the applications of different metal-based NPs as PSs or delivery systems for optimized PDT in cancer treatment. Furthermore, it mechanistically highlights the contribution of RCD pathways during PDT with metal NPs and how these forms of cell death can improve specific PDT regimens in cancer therapy.ElsevierUniversidad Complutense de Madrid20232023-01-0120232023-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/92909reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/929092026-06-02T12:44:21Z
dc.title.none.fl_str_mv Metal-based nanoparticles in cancer therapy: Exploring photodynamic therapy and its interplay with regulated cell death pathways
title Metal-based nanoparticles in cancer therapy: Exploring photodynamic therapy and its interplay with regulated cell death pathways
spellingShingle Metal-based nanoparticles in cancer therapy: Exploring photodynamic therapy and its interplay with regulated cell death pathways
Pashootan, Parya
577.1
616-006.04
Apoptosis
Autophagy Immunogenic cell death
Metallic nanoparticles
Photodynamic therapy
Regulated cell death
Biología celular (Biología)
Bioquímica (Farmacia)
Oncología
2407 Biología Celular
2302 Bioquímica
3201.01 Oncología
title_short Metal-based nanoparticles in cancer therapy: Exploring photodynamic therapy and its interplay with regulated cell death pathways
title_full Metal-based nanoparticles in cancer therapy: Exploring photodynamic therapy and its interplay with regulated cell death pathways
title_fullStr Metal-based nanoparticles in cancer therapy: Exploring photodynamic therapy and its interplay with regulated cell death pathways
title_full_unstemmed Metal-based nanoparticles in cancer therapy: Exploring photodynamic therapy and its interplay with regulated cell death pathways
title_sort Metal-based nanoparticles in cancer therapy: Exploring photodynamic therapy and its interplay with regulated cell death pathways
dc.creator.none.fl_str_mv Pashootan, Parya
Saadati, Fatemeh
Fahimi, Hossein
Rahmati, Marveh
Strippoli, Raffaele
Zarrabi, Ali
Cordani, Marco
Moosavi, Mohammad Amin
author Pashootan, Parya
author_facet Pashootan, Parya
Saadati, Fatemeh
Fahimi, Hossein
Rahmati, Marveh
Strippoli, Raffaele
Zarrabi, Ali
Cordani, Marco
Moosavi, Mohammad Amin
author_role author
author2 Saadati, Fatemeh
Fahimi, Hossein
Rahmati, Marveh
Strippoli, Raffaele
Zarrabi, Ali
Cordani, Marco
Moosavi, Mohammad Amin
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 577.1
616-006.04
Apoptosis
Autophagy Immunogenic cell death
Metallic nanoparticles
Photodynamic therapy
Regulated cell death
Biología celular (Biología)
Bioquímica (Farmacia)
Oncología
2407 Biología Celular
2302 Bioquímica
3201.01 Oncología
topic 577.1
616-006.04
Apoptosis
Autophagy Immunogenic cell death
Metallic nanoparticles
Photodynamic therapy
Regulated cell death
Biología celular (Biología)
Bioquímica (Farmacia)
Oncología
2407 Biología Celular
2302 Bioquímica
3201.01 Oncología
description Photodynamic therapy (PDT) represents a non-invasive treatment strategy currently utilized in the clinical management of selected cancers and infections. This technique is predicated on the administration of a photosensitizer (PS) and subsequent irradiation with light of specific wavelengths, thereby generating reactive oxygen species (ROS) within targeted cells. The cellular effects of PDT are dependent on both the localization of the PS and the severity of ROS challenge, potentially leading to the stimulation of various cell death modalities. For many years, the concept of regulated cell death (RCD) triggered by photodynamic reactions predominantly encompassed apoptosis, necrosis, and autophagy. However, in recent decades, further explorations have unveiled additional cell death modalities, such as necroptosis, ferroptosis, cuproptosis, pyroptosis, parthanatos, and immunogenic cell death (ICD), which helps to achieve tumor cell elimination. Recently, nanoparticles (NPs) have demonstrated substantial advantages over traditional PSs and become important components of PDT, due to their improved physicochemical properties, such as enhanced solubility and superior specificity for targeted cells. This review aims to summarize recent advancements in the applications of different metal-based NPs as PSs or delivery systems for optimized PDT in cancer treatment. Furthermore, it mechanistically highlights the contribution of RCD pathways during PDT with metal NPs and how these forms of cell death can improve specific PDT regimens in cancer therapy.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/92909
url https://hdl.handle.net/20.500.14352/92909
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869424778955194368
score 15,300724

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