Intermediate-onset colorectal cancer: A clinical and familial boundary between both early and late-onset colorectal cancer

Comparative studies of colorectal cancer (CRC) according to the age of onset have found differences between early-onset CRC (EOCRC) and late-onset CRC (LOCRC). Using this as a starting point, we wished to determine whether intermediate-onset CRC (IOCRC) might also be considered as an independent gro...

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Autores: Arriba, María, Sánchez Beltrán, María Del Carmen, Vivas, Alfredo, Nutu, Oana Anisa, Rueda, Daniel, Tapial, Sandra, Rodríguez, Yolanda, García, Juan, Urioste, Miguel, Perea, José
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/117550
Acceso en línea:https://hdl.handle.net/20.500.14352/117550
Access Level:acceso abierto
Palabra clave:616-006.04
Ciencias
32 Ciencias Médicas
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spelling Intermediate-onset colorectal cancer: A clinical and familial boundary between both early and late-onset colorectal cancerArriba, MaríaSánchez Beltrán, María Del CarmenVivas, AlfredoNutu, Oana AnisaRueda, DanielTapial, SandraRodríguez, YolandaGarcía, JuanUrioste, MiguelPerea, José616-006.04Ciencias32 Ciencias MédicasComparative studies of colorectal cancer (CRC) according to the age of onset have found differences between early-onset CRC (EOCRC) and late-onset CRC (LOCRC). Using this as a starting point, we wished to determine whether intermediate-onset CRC (IOCRC) might also be considered as an independent group within CRC. We performed a retrospective comparative study of the clinicopathological and familial features, as well as of the symptoms and their duration, of a total of 272 subjects diagnosed with CRC classified into three groups according to the age-of-onset (98 EOCRC, 83 IOCRC and 91 LOCRC). The results show that from a clinicopathological point of view, IOCRC shared certain features with EOCRC (gender, prognosis), and with LOCRC (multiple primary CRCs), whereas it also had characteristics that were specific for IOCRC (mean number of associated polyps). A gradual progression was observed from EOCRC to LOCRC from a greater family aggregation to sporadic cases, in parallel with a change of Lynch Syndrome cases to the sporadic microsatellite instability pathway, with the IOCRC being a boundary group that is more related to EOCRC. With respect to symptoms, duration and correlation with stages, IOCRC appeared more similar to EOCRC. Clinically, IOCRC behaves as a transitional group between EOCRC and LOCRC, with features in common with both groups, but also with IOCRC-specific features. Excluding cases with familial cancer history, the awareness for EOCRC diagnosis should be extended to IOCRC.PLOSUniversidad Complutense de Madrid20192019-05-1920192019-05-19journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/117550reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1175502026-06-02T12:44:21Z
dc.title.none.fl_str_mv Intermediate-onset colorectal cancer: A clinical and familial boundary between both early and late-onset colorectal cancer
title Intermediate-onset colorectal cancer: A clinical and familial boundary between both early and late-onset colorectal cancer
spellingShingle Intermediate-onset colorectal cancer: A clinical and familial boundary between both early and late-onset colorectal cancer
Arriba, María
616-006.04
Ciencias
32 Ciencias Médicas
title_short Intermediate-onset colorectal cancer: A clinical and familial boundary between both early and late-onset colorectal cancer
title_full Intermediate-onset colorectal cancer: A clinical and familial boundary between both early and late-onset colorectal cancer
title_fullStr Intermediate-onset colorectal cancer: A clinical and familial boundary between both early and late-onset colorectal cancer
title_full_unstemmed Intermediate-onset colorectal cancer: A clinical and familial boundary between both early and late-onset colorectal cancer
title_sort Intermediate-onset colorectal cancer: A clinical and familial boundary between both early and late-onset colorectal cancer
dc.creator.none.fl_str_mv Arriba, María
Sánchez Beltrán, María Del Carmen
Vivas, Alfredo
Nutu, Oana Anisa
Rueda, Daniel
Tapial, Sandra
Rodríguez, Yolanda
García, Juan
Urioste, Miguel
Perea, José
author Arriba, María
author_facet Arriba, María
Sánchez Beltrán, María Del Carmen
Vivas, Alfredo
Nutu, Oana Anisa
Rueda, Daniel
Tapial, Sandra
Rodríguez, Yolanda
García, Juan
Urioste, Miguel
Perea, José
author_role author
author2 Sánchez Beltrán, María Del Carmen
Vivas, Alfredo
Nutu, Oana Anisa
Rueda, Daniel
Tapial, Sandra
Rodríguez, Yolanda
García, Juan
Urioste, Miguel
Perea, José
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616-006.04
Ciencias
32 Ciencias Médicas
topic 616-006.04
Ciencias
32 Ciencias Médicas
description Comparative studies of colorectal cancer (CRC) according to the age of onset have found differences between early-onset CRC (EOCRC) and late-onset CRC (LOCRC). Using this as a starting point, we wished to determine whether intermediate-onset CRC (IOCRC) might also be considered as an independent group within CRC. We performed a retrospective comparative study of the clinicopathological and familial features, as well as of the symptoms and their duration, of a total of 272 subjects diagnosed with CRC classified into three groups according to the age-of-onset (98 EOCRC, 83 IOCRC and 91 LOCRC). The results show that from a clinicopathological point of view, IOCRC shared certain features with EOCRC (gender, prognosis), and with LOCRC (multiple primary CRCs), whereas it also had characteristics that were specific for IOCRC (mean number of associated polyps). A gradual progression was observed from EOCRC to LOCRC from a greater family aggregation to sporadic cases, in parallel with a change of Lynch Syndrome cases to the sporadic microsatellite instability pathway, with the IOCRC being a boundary group that is more related to EOCRC. With respect to symptoms, duration and correlation with stages, IOCRC appeared more similar to EOCRC. Clinically, IOCRC behaves as a transitional group between EOCRC and LOCRC, with features in common with both groups, but also with IOCRC-specific features. Excluding cases with familial cancer history, the awareness for EOCRC diagnosis should be extended to IOCRC.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-05-19
2019
2019-05-19
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/117550
url https://hdl.handle.net/20.500.14352/117550
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv PLOS
publisher.none.fl_str_mv PLOS
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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