Sleep disorders in immune-mediated synaptic encephalopathies
[eng] INTRODUCTION: Autoimmune encephalitis (AEI) is an inflammatory disease of the central nervous system, caused by specific antibodies against synaptic or neural surface proteins. More than twenty have been described in the last two decades, with specific antibodies and clinical syndromes. They p...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/219712 |
| Acceso en línea: | https://hdl.handle.net/2445/219712 http://hdl.handle.net/10803/693996 |
| Access Level: | acceso abierto |
| Palabra clave: | Neuroimmunologia Encefalitis Trastorns del son Neuroimmunology Encephalitis Sleep disorders |
| Sumario: | [eng] INTRODUCTION: Autoimmune encephalitis (AEI) is an inflammatory disease of the central nervous system, caused by specific antibodies against synaptic or neural surface proteins. More than twenty have been described in the last two decades, with specific antibodies and clinical syndromes. They produce a wide variety of symptoms, including cognitive and psychiatric alterations, movement disorders or epileptic seizures. Sleep disorders in AEIs have received little attention, probably overshadowed by more prominent symptoms, but the scarce literature available suggests that they are common, often severe and in some cases persistent. Anti-NMDAR encephalitis and anti-LG1 encephalitis are the two most common AEIs and sleep disorders, although described in both, have not been systematically studied or characterized and their frequency, intensity and evolution are unknown. HYPOTHESIS: 1) Sleep disorders in anti-NMDAR encephalitis have been rarely described in the literature, but a systematic evaluation would reveal a higher prevalence than described. 2) Sleep disorders persist in the post-acute phase of anti-NMDAR encephalitis. 3) Systematic video-polysomnographic study in the post-acute phase of anti-NMDAR encephalitis may reveal previously undescribed sleep disorders. 4) Sleep disorders in the acute phase of anti-LGI1 encephalitis have not been well characterized and a systematic evaluation could reveal that they are more prevalent and diverse than previously described. 5) Sleep disorders persist in the post-acute phase of anti-LGI1 encephalitis. 6) The systematic and longitudinal study with video-polysomnography in the post-acute phase of anti-LGI1 encephalitis could unmask sleep disorders previously not described in this phase of the disease. 7) Epileptic seizures may persist in the post-acute phase of anti-LGI1 encephalitis and systematic study with nocturnal and diurnal electroencephalogram could help identify subclinical seizures or determine the risk of developing chronic epilepsy. OBJECTIVES: 1) To determine the frequency and characterize the type of sleep disorders that occur in the acute and post-acute phase of anti-NMDAR encephalitis. 2) Video-polysomnographic characterization of sleep in the post-acute phase of anti-NMDAR encephalitis. 3) To describe the profile of neurological symptoms and sleep disorders in the acute and post-acute phase of anti-LGI1 encephalitis. 4) To characterize video-polysomnographically and electroencephalographically sleep in the post-acute phase of anti-LGI1 encephalitis. |
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