Bioavailability profiling shows differences in OA, DTX1 and DTX2 toxins that justify their toxicity

The marine toxins of the Okadaic acid (OA) group are natural compounds produced by dinoflagellates that enters the food chain by accumulating in seafood. They are responsible for Diarrhetic Shellfish Poisoning (DSP) events in humans over the world and therefore are also jointly named as Diarrhetic S...

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Autores: Rodríguez Santos, Luis, Costas, Celia, Louzao Ojeda, María del Carmen, Cagide, Eva, Álvarez, Mercedes, Rodríguez Cañás, Inés, Raposo García, Sandra, Vale González, María del Carmen, Rodríguez Vieytes, Mercedes, Lolo, Manuel, Botana López, Luis Miguel
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/39844
Acceso en línea:https://hdl.handle.net/10347/39844
Access Level:acceso abierto
Palabra clave:Diarrhetic shellfish poisoning
Okadaic acid
Pharmacokinetic
Voluntary feeding
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spelling Bioavailability profiling shows differences in OA, DTX1 and DTX2 toxins that justify their toxicityRodríguez Santos, LuisCostas, CeliaLouzao Ojeda, María del CarmenCagide, EvaÁlvarez, MercedesRodríguez Cañás, InésRaposo García, SandraVale González, María del CarmenRodríguez Vieytes, MercedesLolo, ManuelBotana López, Luis MiguelDiarrhetic shellfish poisoningOkadaic acidPharmacokineticVoluntary feedingThe marine toxins of the Okadaic acid (OA) group are natural compounds produced by dinoflagellates that enters the food chain by accumulating in seafood. They are responsible for Diarrhetic Shellfish Poisoning (DSP) events in humans over the world and therefore are also jointly named as Diarrhetic Shellfish Toxins (DSTs). The main objective of this study was to evaluate symptoms, toxicity, absorption, distribution, and elimination of OA, Dinophysistoxin-1 (DTX1), and Dinophysistoxin-2 (DTX2) at the sublethal dose of 90 μg toxin/kg bw administered through voluntary feeding to mice. The toxin comparison highlighted that OA and DTX1 induced more severe and specific symptoms such as diarrhea. After oral ingestion toxins were distributed through the entire organism being detected in liver, kidney, stomach, small and large intestine. Predominant excretion of the toxins was observed in feces, with OA exhibiting fast elimination, while DTX2 was showing prolonged excretion. The passage and accumulation of toxins in gastrointestinal organs instigated macroscopic damage in the stomach, small and large intestine that could persist up to 120 h. These findings highlight the importance of pharmacokinetic of sublethal doses of DSTs administered by voluntary feeding in their toxicity and their implication for public health.ElsevierUniversidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía FarmacéuticaUniversidade de Santiago de Compostela. Departamento de Fisioloxía20242024-09-2820242024-09-28journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10347/39844reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 CPP2021-008447 Evaluación de los efectos de las toxinas diarreicas de mariscos (DSP) tras una ingesta continuada y sus implicaciones neurológicas (CRONIC-DSP)open accesshttp://purl.org/coar/access_right/c_abf2© 2024 The Authors. Published by Elsevier Ltdhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/398442026-06-15T12:47:27Z
dc.title.none.fl_str_mv Bioavailability profiling shows differences in OA, DTX1 and DTX2 toxins that justify their toxicity
title Bioavailability profiling shows differences in OA, DTX1 and DTX2 toxins that justify their toxicity
spellingShingle Bioavailability profiling shows differences in OA, DTX1 and DTX2 toxins that justify their toxicity
Rodríguez Santos, Luis
Diarrhetic shellfish poisoning
Okadaic acid
Pharmacokinetic
Voluntary feeding
title_short Bioavailability profiling shows differences in OA, DTX1 and DTX2 toxins that justify their toxicity
title_full Bioavailability profiling shows differences in OA, DTX1 and DTX2 toxins that justify their toxicity
title_fullStr Bioavailability profiling shows differences in OA, DTX1 and DTX2 toxins that justify their toxicity
title_full_unstemmed Bioavailability profiling shows differences in OA, DTX1 and DTX2 toxins that justify their toxicity
title_sort Bioavailability profiling shows differences in OA, DTX1 and DTX2 toxins that justify their toxicity
dc.creator.none.fl_str_mv Rodríguez Santos, Luis
Costas, Celia
Louzao Ojeda, María del Carmen
Cagide, Eva
Álvarez, Mercedes
Rodríguez Cañás, Inés
Raposo García, Sandra
Vale González, María del Carmen
Rodríguez Vieytes, Mercedes
Lolo, Manuel
Botana López, Luis Miguel
author Rodríguez Santos, Luis
author_facet Rodríguez Santos, Luis
Costas, Celia
Louzao Ojeda, María del Carmen
Cagide, Eva
Álvarez, Mercedes
Rodríguez Cañás, Inés
Raposo García, Sandra
Vale González, María del Carmen
Rodríguez Vieytes, Mercedes
Lolo, Manuel
Botana López, Luis Miguel
author_role author
author2 Costas, Celia
Louzao Ojeda, María del Carmen
Cagide, Eva
Álvarez, Mercedes
Rodríguez Cañás, Inés
Raposo García, Sandra
Vale González, María del Carmen
Rodríguez Vieytes, Mercedes
Lolo, Manuel
Botana López, Luis Miguel
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica
Universidade de Santiago de Compostela. Departamento de Fisioloxía
dc.subject.none.fl_str_mv Diarrhetic shellfish poisoning
Okadaic acid
Pharmacokinetic
Voluntary feeding
topic Diarrhetic shellfish poisoning
Okadaic acid
Pharmacokinetic
Voluntary feeding
description The marine toxins of the Okadaic acid (OA) group are natural compounds produced by dinoflagellates that enters the food chain by accumulating in seafood. They are responsible for Diarrhetic Shellfish Poisoning (DSP) events in humans over the world and therefore are also jointly named as Diarrhetic Shellfish Toxins (DSTs). The main objective of this study was to evaluate symptoms, toxicity, absorption, distribution, and elimination of OA, Dinophysistoxin-1 (DTX1), and Dinophysistoxin-2 (DTX2) at the sublethal dose of 90 μg toxin/kg bw administered through voluntary feeding to mice. The toxin comparison highlighted that OA and DTX1 induced more severe and specific symptoms such as diarrhea. After oral ingestion toxins were distributed through the entire organism being detected in liver, kidney, stomach, small and large intestine. Predominant excretion of the toxins was observed in feces, with OA exhibiting fast elimination, while DTX2 was showing prolonged excretion. The passage and accumulation of toxins in gastrointestinal organs instigated macroscopic damage in the stomach, small and large intestine that could persist up to 120 h. These findings highlight the importance of pharmacokinetic of sublethal doses of DSTs administered by voluntary feeding in their toxicity and their implication for public health.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-09-28
2024
2024-09-28
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10347/39844
url https://hdl.handle.net/10347/39844
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 CPP2021-008447 Evaluación de los efectos de las toxinas diarreicas de mariscos (DSP) tras una ingesta continuada y sus implicaciones neurológicas (CRONIC-DSP)
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
© 2024 The Authors. Published by Elsevier Ltd
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
© 2024 The Authors. Published by Elsevier Ltd
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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