Multifunctional PLA/Gelatin Bionanocomposites for Tailored Drug Delivery Systems

21 pages, 10 figures, 2 tables.-- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license

Detalles Bibliográficos
Autores: Moya-López, Carmen, Juan, Alberto, Donizeti, Murillo, Valcárcel Barros, Jesús, Vázquez, José Antonio, Solano, Eduardo, Chapron, David, Bourson, Patrice, Bravo, Iván, Alonso-Moreno, Carlos, Clemente-Casares, Pilar, Gracia-Fernández, Carlos, Longo, Alessandro, Salloum-Abou-Jaoude, Georges, Ocaña, Alberto, Piñeiro, Manuel M., Hermida-Merino, Carolina, Hermida-Merino, Daniel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/284918
Acceso en línea:http://hdl.handle.net/10261/284918
Access Level:acceso abierto
Palabra clave:Bionanocomposite
Gelatin
Polylactide
Stereocomplex
Hydrogel
Nanoparticles
Drug delivery
id ES_f629554d59dae6ca5cc7d558ce6f53bb
oai_identifier_str oai:digital.csic.es:10261/284918
network_acronym_str ES
network_name_str España
repository_id_str
spelling Multifunctional PLA/Gelatin Bionanocomposites for Tailored Drug Delivery SystemsMoya-López, CarmenJuan, AlbertoDonizeti, MurilloValcárcel Barros, JesúsVázquez, José AntonioSolano, EduardoChapron, DavidBourson, PatriceBravo, IvánAlonso-Moreno, CarlosClemente-Casares, PilarGracia-Fernández, CarlosLongo, AlessandroSalloum-Abou-Jaoude, GeorgesOcaña, AlbertoPiñeiro, Manuel M.Hermida-Merino, CarolinaHermida-Merino, DanielBionanocompositeGelatinPolylactideStereocomplexHydrogelNanoparticlesDrug delivery21 pages, 10 figures, 2 tables.-- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licenseA series of bionanocomposites composed of shark gelatin hydrogels and PLA nanoparticles featuring different nanostructures were designed to generate multifunctional drug delivery systems with tailored release rates required for personalized treatment approaches. The global conception of the systems was considered from the desired customization of the drug release while featuring the viscoelastic properties needed for their ease of storage and posterior local administration as well as their biocompatibility and cell growth capability for the successful administration at the biomolecular level. The hydrogel matrix offers the support to develop a direct thermal method to convert the typical kinetic trapped nanostructures afforded by the formulation method whilst avoiding the detrimental nanoparticle agglomeration that diminishes their therapeutic effect. The nanoparticles generated were successfully formulated with two different antitumoral compounds (doxorubicin and dasatinib) possessing different structures to prove the loading versatility of the drug delivery system. The bionanocomposites were characterized by several techniques (SEM, DLS, RAMAN, DSC, SAXS/WAXS and rheology) as well as their reversible sol–gel transition upon thermal treatment that occurs during the drug delivery system preparation and the thermal annealing step. In addition, the local applicability of the drug delivery system was assessed by the so-called “syringe test” to validate both the storage capability and its flow properties at simulated physiological conditions. Finally, the drug release profiles of the doxorubicin from both the PLA nanoparticles or the bionanocomposites were analyzed and correlated to the nanostructure of the drug delivery systemWe gratefully acknowledge the financial support from the Ministerio de Ciencia e Innovación y Agencia Estatal de la Investigación (10.13039/501100011033), Spain (Grant Nos. PID2020- 117788RB-I00, CTQ2017-84131-R and RED2018-102387-T Programa Redes Consolider)Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/284918reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-117788RB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-84131-RThe underlying dataset has been published as supplementary material of the article in the publishers platform at DOI https://doi.org/10.3390/pharmaceutics14061138https://doi.org/10.3390/pharmaceutics14061138Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2849182026-05-22T06:33:51Z
dc.title.none.fl_str_mv Multifunctional PLA/Gelatin Bionanocomposites for Tailored Drug Delivery Systems
title Multifunctional PLA/Gelatin Bionanocomposites for Tailored Drug Delivery Systems
spellingShingle Multifunctional PLA/Gelatin Bionanocomposites for Tailored Drug Delivery Systems
Moya-López, Carmen
Bionanocomposite
Gelatin
Polylactide
Stereocomplex
Hydrogel
Nanoparticles
Drug delivery
title_short Multifunctional PLA/Gelatin Bionanocomposites for Tailored Drug Delivery Systems
title_full Multifunctional PLA/Gelatin Bionanocomposites for Tailored Drug Delivery Systems
title_fullStr Multifunctional PLA/Gelatin Bionanocomposites for Tailored Drug Delivery Systems
title_full_unstemmed Multifunctional PLA/Gelatin Bionanocomposites for Tailored Drug Delivery Systems
title_sort Multifunctional PLA/Gelatin Bionanocomposites for Tailored Drug Delivery Systems
dc.creator.none.fl_str_mv Moya-López, Carmen
Juan, Alberto
Donizeti, Murillo
Valcárcel Barros, Jesús
Vázquez, José Antonio
Solano, Eduardo
Chapron, David
Bourson, Patrice
Bravo, Iván
Alonso-Moreno, Carlos
Clemente-Casares, Pilar
Gracia-Fernández, Carlos
Longo, Alessandro
Salloum-Abou-Jaoude, Georges
Ocaña, Alberto
Piñeiro, Manuel M.
Hermida-Merino, Carolina
Hermida-Merino, Daniel
author Moya-López, Carmen
author_facet Moya-López, Carmen
Juan, Alberto
Donizeti, Murillo
Valcárcel Barros, Jesús
Vázquez, José Antonio
Solano, Eduardo
Chapron, David
Bourson, Patrice
Bravo, Iván
Alonso-Moreno, Carlos
Clemente-Casares, Pilar
Gracia-Fernández, Carlos
Longo, Alessandro
Salloum-Abou-Jaoude, Georges
Ocaña, Alberto
Piñeiro, Manuel M.
Hermida-Merino, Carolina
Hermida-Merino, Daniel
author_role author
author2 Juan, Alberto
Donizeti, Murillo
Valcárcel Barros, Jesús
Vázquez, José Antonio
Solano, Eduardo
Chapron, David
Bourson, Patrice
Bravo, Iván
Alonso-Moreno, Carlos
Clemente-Casares, Pilar
Gracia-Fernández, Carlos
Longo, Alessandro
Salloum-Abou-Jaoude, Georges
Ocaña, Alberto
Piñeiro, Manuel M.
Hermida-Merino, Carolina
Hermida-Merino, Daniel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Agencia Estatal de Investigación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Bionanocomposite
Gelatin
Polylactide
Stereocomplex
Hydrogel
Nanoparticles
Drug delivery
topic Bionanocomposite
Gelatin
Polylactide
Stereocomplex
Hydrogel
Nanoparticles
Drug delivery
description 21 pages, 10 figures, 2 tables.-- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/284918
url http://hdl.handle.net/10261/284918
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-117788RB-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-84131-R
The underlying dataset has been published as supplementary material of the article in the publishers platform at DOI https://doi.org/10.3390/pharmaceutics14061138
https://doi.org/10.3390/pharmaceutics14061138
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869424710485278720
score 15,81155

Similares en LA Referencia