Experimental ovine toxoplasmosis: influence of the gestational stage on the clinical course, lesion development and parasite distribution
P. 1-14
| Autores: | , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | Universidad de León |
| Repositorio: | BULERIA. Repositorio Institucional de la Universidad de León |
| OAI Identifier: | oai:buleria.unileon.es:10612/12292 |
| Acceso en línea: | https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-016-0327-z http://hdl.handle.net/10612/12292 https://doi.org/10.1186/s13567-016-0327-z |
| Access Level: | acceso abierto |
| Palabra clave: | Veterinaria Ganado ovino Toxoplasmosis Embarazo Parásitos 2401.12 Parasitología Animal |
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Experimental ovine toxoplasmosis: influence of the gestational stage on the clinical course, lesion development and parasite distributionCastaño Labajo, PabloFuertes Franco, MiguelRegidor Cerrillo, JavierFerré Pérez, IgnacioFernández Fernández, MiguelFerreras Estrada, María Del CarmenMoreno Gonzalo, JavierGonzález Lanza, María del CaminoPereira Bueno, Juana María de la CruzKatzer, FrankOrtega Mora, Luis MiguelPérez Pérez, ValentínBenavides Silván, JulioVeterinariaGanado ovinoToxoplasmosisEmbarazoParásitos2401.12 Parasitología AnimalP. 1-14The relation between gestational age and foetal death risk in ovine toxoplasmosis is already known, but the mechanisms involved are not yet clear. In order to study how the stage of gestation influences these mechanisms, pregnant sheep of the same age and genetic background were orally dosed with 50 oocysts of Toxoplasma gondii (M4 isolate) at days 40 (G1), 90 (G2) and 120 (G3) of gestation. In each group, four animals were culled on the second, third and fourth week post infection (pi) in order to evaluate parasite load and distribution, and lesions in target organs. Ewes from G1 showed a longer period of hyperthermia than the other groups. Abortions occurred in all groups. While in G2 they were more frequent during the acute phase of the disease, in G3 they mainly occurred after day 20 pi. After challenge, parasite and lesions in the placentas and foetuses were detected from day 19 pi in G3 while in G2 or G1 they were only detected at day 26 pi. However, after initial detection at day 19 pi, parasite burden, measured through RT-PCR, in placenta or foetus of G3 did not increase significantly and, at in the third week pi it was lower than that measured in foetal liver or placenta from G1 to G3 respectively. These results show that the period of gestation clearly influences the parasite multiplication and development of lesions in the placenta and foetus and, as a consequence, the clinical course in ovine toxoplasmosis.SISpringerSanidad AnimalFacultad de Veterinaria2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-016-0327-zhttp://hdl.handle.net/10612/12292https://doi.org/10.1186/s13567-016-0327-zreponame:BULERIA. Repositorio Institucional de la Universidad de Leóninstname:Universidad de LeónInglésinfo:eu-repo/semantics/openAccessoai:buleria.unileon.es:10612/122922026-06-24T12:43:27Z |
| dc.title.none.fl_str_mv |
Experimental ovine toxoplasmosis: influence of the gestational stage on the clinical course, lesion development and parasite distribution |
| title |
Experimental ovine toxoplasmosis: influence of the gestational stage on the clinical course, lesion development and parasite distribution |
| spellingShingle |
Experimental ovine toxoplasmosis: influence of the gestational stage on the clinical course, lesion development and parasite distribution Castaño Labajo, Pablo Veterinaria Ganado ovino Toxoplasmosis Embarazo Parásitos 2401.12 Parasitología Animal |
| title_short |
Experimental ovine toxoplasmosis: influence of the gestational stage on the clinical course, lesion development and parasite distribution |
| title_full |
Experimental ovine toxoplasmosis: influence of the gestational stage on the clinical course, lesion development and parasite distribution |
| title_fullStr |
Experimental ovine toxoplasmosis: influence of the gestational stage on the clinical course, lesion development and parasite distribution |
| title_full_unstemmed |
Experimental ovine toxoplasmosis: influence of the gestational stage on the clinical course, lesion development and parasite distribution |
| title_sort |
Experimental ovine toxoplasmosis: influence of the gestational stage on the clinical course, lesion development and parasite distribution |
| dc.creator.none.fl_str_mv |
Castaño Labajo, Pablo Fuertes Franco, Miguel Regidor Cerrillo, Javier Ferré Pérez, Ignacio Fernández Fernández, Miguel Ferreras Estrada, María Del Carmen Moreno Gonzalo, Javier González Lanza, María del Camino Pereira Bueno, Juana María de la Cruz Katzer, Frank Ortega Mora, Luis Miguel Pérez Pérez, Valentín Benavides Silván, Julio |
| author |
Castaño Labajo, Pablo |
| author_facet |
Castaño Labajo, Pablo Fuertes Franco, Miguel Regidor Cerrillo, Javier Ferré Pérez, Ignacio Fernández Fernández, Miguel Ferreras Estrada, María Del Carmen Moreno Gonzalo, Javier González Lanza, María del Camino Pereira Bueno, Juana María de la Cruz Katzer, Frank Ortega Mora, Luis Miguel Pérez Pérez, Valentín Benavides Silván, Julio |
| author_role |
author |
| author2 |
Fuertes Franco, Miguel Regidor Cerrillo, Javier Ferré Pérez, Ignacio Fernández Fernández, Miguel Ferreras Estrada, María Del Carmen Moreno Gonzalo, Javier González Lanza, María del Camino Pereira Bueno, Juana María de la Cruz Katzer, Frank Ortega Mora, Luis Miguel Pérez Pérez, Valentín Benavides Silván, Julio |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Sanidad Animal Facultad de Veterinaria |
| dc.subject.none.fl_str_mv |
Veterinaria Ganado ovino Toxoplasmosis Embarazo Parásitos 2401.12 Parasitología Animal |
| topic |
Veterinaria Ganado ovino Toxoplasmosis Embarazo Parásitos 2401.12 Parasitología Animal |
| description |
P. 1-14 |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-016-0327-z http://hdl.handle.net/10612/12292 https://doi.org/10.1186/s13567-016-0327-z |
| url |
https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-016-0327-z http://hdl.handle.net/10612/12292 https://doi.org/10.1186/s13567-016-0327-z |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Springer |
| publisher.none.fl_str_mv |
Springer |
| dc.source.none.fl_str_mv |
reponame:BULERIA. Repositorio Institucional de la Universidad de León instname:Universidad de León |
| instname_str |
Universidad de León |
| reponame_str |
BULERIA. Repositorio Institucional de la Universidad de León |
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BULERIA. Repositorio Institucional de la Universidad de León |
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1869424657033068544 |
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15,300724 |