The mitochondria-targeted antioxidant MitoQ modulates oxidative stress, inflammation and leukocyte-endothelium interactions in leukocytes isolated from type 2 diabetic patients

It is not known if the mitochondria-targeted antioxidants such as mitoquinone (MitoQ) can modulate oxidative stress and leukocyte-endothelium interactions in T2D patients. We aimed to evaluate the beneficial effect of MitoQ on oxidative stress parameters and leukocyte-endothelium interactions in leu...

Descripción completa

Detalles Bibliográficos
Autores: Escribano-Lopez, I, Diaz-Morales, N, Rovira-Llopis, S, de Maranon, AM, Orden, S, Alvarez, A, Banuls, C, Rocha, M, Murphy, MP, Hernandez-Mijares, A, Victor, VM
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p3018
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/3018
Access Level:acceso abierto
Palabra clave:Leukocytes
Oxidative stress
Inflammation
Endothelium
Type 2 diabetes
MitoQ
id ES_f5da2eb25bf64eb587a028e856570178
oai_identifier_str oai:incliva.fundanetsuite.com:p3018
network_acronym_str ES
network_name_str España
repository_id_str
spelling The mitochondria-targeted antioxidant MitoQ modulates oxidative stress, inflammation and leukocyte-endothelium interactions in leukocytes isolated from type 2 diabetic patientsEscribano-Lopez, IDiaz-Morales, NRovira-Llopis, Sde Maranon, AMOrden, SAlvarez, ABanuls, CRocha, MMurphy, MPHernandez-Mijares, AVictor, VMLeukocytesOxidative stressInflammationEndotheliumType 2 diabetesMitoQIt is not known if the mitochondria-targeted antioxidants such as mitoquinone (MitoQ) can modulate oxidative stress and leukocyte-endothelium interactions in T2D patients. We aimed to evaluate the beneficial effect of MitoQ on oxidative stress parameters and leukocyte-endothelium interactions in leukocytes of T2D patients. The study population consisted of 98 T2D patients and 71 control subjects. We assessed metabolic and anthropometric parameters, mitochondrial reactive oxygen species (ROS) production, glutathione peroxidase 1 (GPX-1), NF kappa B-p65, TNF alpha and leukocyte-endothelium interactions. Diabetic patients exhibited higher weight, BMI, waist circumference, SBP, DBP, glucose, insulin, HOMA-IR, HbA1c, triglycerides, hs-CRP and lower HDL-c with respect to controls. Mitochondrial ROS production was enhanced in T2D patients and decreased by MitoQ. The antioxidant also increased GPX-1 levels and PMN rolling velocity and decreased PMN rolling flux and PMN adhesion in T2D patients. NF kappa B-p65 and TNF alpha were augmented in T2D and were both reduced by MitoQ treatment. Our findings support that the antioxidant MitoQ has an anti-inflammatory and antioxidant action in the leukocytes of T2D patients by decreasing ROS production, leukocyte-endothelium interactions and TNF alpha through the action of NF kappa B. These data suggest that mitochondria-targeted antioxidants such as MitoQ should be investigated as a novel means of preventing cardiovascular events in T2D patients.ELSEVIER2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/3018Redox BiologyISSN: 22132317reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p30182026-06-07T16:35:31Z
dc.title.none.fl_str_mv The mitochondria-targeted antioxidant MitoQ modulates oxidative stress, inflammation and leukocyte-endothelium interactions in leukocytes isolated from type 2 diabetic patients
title The mitochondria-targeted antioxidant MitoQ modulates oxidative stress, inflammation and leukocyte-endothelium interactions in leukocytes isolated from type 2 diabetic patients
spellingShingle The mitochondria-targeted antioxidant MitoQ modulates oxidative stress, inflammation and leukocyte-endothelium interactions in leukocytes isolated from type 2 diabetic patients
Escribano-Lopez, I
Leukocytes
Oxidative stress
Inflammation
Endothelium
Type 2 diabetes
MitoQ
title_short The mitochondria-targeted antioxidant MitoQ modulates oxidative stress, inflammation and leukocyte-endothelium interactions in leukocytes isolated from type 2 diabetic patients
title_full The mitochondria-targeted antioxidant MitoQ modulates oxidative stress, inflammation and leukocyte-endothelium interactions in leukocytes isolated from type 2 diabetic patients
title_fullStr The mitochondria-targeted antioxidant MitoQ modulates oxidative stress, inflammation and leukocyte-endothelium interactions in leukocytes isolated from type 2 diabetic patients
title_full_unstemmed The mitochondria-targeted antioxidant MitoQ modulates oxidative stress, inflammation and leukocyte-endothelium interactions in leukocytes isolated from type 2 diabetic patients
title_sort The mitochondria-targeted antioxidant MitoQ modulates oxidative stress, inflammation and leukocyte-endothelium interactions in leukocytes isolated from type 2 diabetic patients
dc.creator.none.fl_str_mv Escribano-Lopez, I
Diaz-Morales, N
Rovira-Llopis, S
de Maranon, AM
Orden, S
Alvarez, A
Banuls, C
Rocha, M
Murphy, MP
Hernandez-Mijares, A
Victor, VM
author Escribano-Lopez, I
author_facet Escribano-Lopez, I
Diaz-Morales, N
Rovira-Llopis, S
de Maranon, AM
Orden, S
Alvarez, A
Banuls, C
Rocha, M
Murphy, MP
Hernandez-Mijares, A
Victor, VM
author_role author
author2 Diaz-Morales, N
Rovira-Llopis, S
de Maranon, AM
Orden, S
Alvarez, A
Banuls, C
Rocha, M
Murphy, MP
Hernandez-Mijares, A
Victor, VM
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Leukocytes
Oxidative stress
Inflammation
Endothelium
Type 2 diabetes
MitoQ
topic Leukocytes
Oxidative stress
Inflammation
Endothelium
Type 2 diabetes
MitoQ
description It is not known if the mitochondria-targeted antioxidants such as mitoquinone (MitoQ) can modulate oxidative stress and leukocyte-endothelium interactions in T2D patients. We aimed to evaluate the beneficial effect of MitoQ on oxidative stress parameters and leukocyte-endothelium interactions in leukocytes of T2D patients. The study population consisted of 98 T2D patients and 71 control subjects. We assessed metabolic and anthropometric parameters, mitochondrial reactive oxygen species (ROS) production, glutathione peroxidase 1 (GPX-1), NF kappa B-p65, TNF alpha and leukocyte-endothelium interactions. Diabetic patients exhibited higher weight, BMI, waist circumference, SBP, DBP, glucose, insulin, HOMA-IR, HbA1c, triglycerides, hs-CRP and lower HDL-c with respect to controls. Mitochondrial ROS production was enhanced in T2D patients and decreased by MitoQ. The antioxidant also increased GPX-1 levels and PMN rolling velocity and decreased PMN rolling flux and PMN adhesion in T2D patients. NF kappa B-p65 and TNF alpha were augmented in T2D and were both reduced by MitoQ treatment. Our findings support that the antioxidant MitoQ has an anti-inflammatory and antioxidant action in the leukocytes of T2D patients by decreasing ROS production, leukocyte-endothelium interactions and TNF alpha through the action of NF kappa B. These data suggest that mitochondria-targeted antioxidants such as MitoQ should be investigated as a novel means of preventing cardiovascular events in T2D patients.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/3018
url https://incliva.portalinvestigacion.com/publicaciones/3018
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER
publisher.none.fl_str_mv ELSEVIER
dc.source.none.fl_str_mv Redox Biology
ISSN: 22132317
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869424654623440896
score 15,81155

Similares en LA Referencia