Resting-state default mode network connectivity in young individuals with Down syndrome

Background: Down syndrome (DS) is a chromosomal disorder that causes intellectual disability. Few studies have been conducted on functional connectivity using restingstate fMRI (functional magnetic resonance imaging) signals or more specifically, on the relevant structure and density of the default...

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Autores: Figueroa Jiménez, María Dolores, Cañete-Massé, Cristina, Carbó-Carreté, Maria, Zarabozo-Hurtado, Daniel, Peró, Maribel, Salazar Estrada, José Guadalupe, Guàrdia-Olmos, Joan, 1958-
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2020
País:España
Recursos:Universidad de Barcelona
Repositório:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/173560
Acesso em linha:https://hdl.handle.net/2445/173560
Access Level:Acceso aberto
Palavra-chave:Síndrome de Down
Joves discapacitats mentals
Imatges per ressonància magnètica
Mapatge del cervell
Neurologia
Down syndrome
Youth with mental disabilities
Magnetic resonance imaging
Brain mapping
Neurology
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spelling Resting-state default mode network connectivity in young individuals with Down syndromeFigueroa Jiménez, María DoloresCañete-Massé, CristinaCarbó-Carreté, MariaZarabozo-Hurtado, DanielPeró, MaribelSalazar Estrada, José GuadalupeGuàrdia-Olmos, Joan, 1958-Síndrome de DownJoves discapacitats mentalsImatges per ressonància magnèticaMapatge del cervellNeurologiaDown syndromeYouth with mental disabilitiesMagnetic resonance imagingBrain mappingNeurologyBackground: Down syndrome (DS) is a chromosomal disorder that causes intellectual disability. Few studies have been conducted on functional connectivity using restingstate fMRI (functional magnetic resonance imaging) signals or more specifically, on the relevant structure and density of the default mode network (DMN). Although data on this issue have been reported in adult DS individuals (age: >45 years), the DMN properties in young DS individuals have not been studied. The aim of this study was to describe the density and structure of the DMN network from fMRI signals in young DS (age: <36 years). Method: A sample of 22 young people with DS between the ages of 16 and 35 (M = 25.5 and SD = 5.1) was recruited in various centers for people with intellectual disability (ID). In addition to sociodemographic data, a six-minute fMRI session was recorded with a 3. T Philips Ingenia scanner. A control group of 22 young people, matched by age and gender, was obtained from the Human Connectome Project (to compare the networks properties between groups). Results: The values of the 48 ROIs that configured the DMN were obtained, and the connectivity graphs for each subject, the average connectivity graph for each group, the clustering and degree values for each ROI, and the average functional connectivity network were estimated. Conclusions: A higher density of overactivation was identified in DS group in the ventral, sensorimotor, and visual DMN networks, although within a framework of a wide variability of connectivity patterns in comparison with the control group network. These results extend our understanding of the functional connectivity networks pattern and intrasubject variability in DS.John Wiley & Sons2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/173560Articles publicats en revistes (Psicologia Social i Psicologia Quantitativa)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1002/brb3.1905Brain and Behavior, 2020, vol. 11, num. 1, p. e01905https://doi.org/10.1002/brb3.1905cc-by (c) Figueroa-Jimenez, María Dolores et al., 2020http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1735602026-05-27T06:46:51Z
dc.title.none.fl_str_mv Resting-state default mode network connectivity in young individuals with Down syndrome
title Resting-state default mode network connectivity in young individuals with Down syndrome
spellingShingle Resting-state default mode network connectivity in young individuals with Down syndrome
Figueroa Jiménez, María Dolores
Síndrome de Down
Joves discapacitats mentals
Imatges per ressonància magnètica
Mapatge del cervell
Neurologia
Down syndrome
Youth with mental disabilities
Magnetic resonance imaging
Brain mapping
Neurology
title_short Resting-state default mode network connectivity in young individuals with Down syndrome
title_full Resting-state default mode network connectivity in young individuals with Down syndrome
title_fullStr Resting-state default mode network connectivity in young individuals with Down syndrome
title_full_unstemmed Resting-state default mode network connectivity in young individuals with Down syndrome
title_sort Resting-state default mode network connectivity in young individuals with Down syndrome
dc.creator.none.fl_str_mv Figueroa Jiménez, María Dolores
Cañete-Massé, Cristina
Carbó-Carreté, Maria
Zarabozo-Hurtado, Daniel
Peró, Maribel
Salazar Estrada, José Guadalupe
Guàrdia-Olmos, Joan, 1958-
author Figueroa Jiménez, María Dolores
author_facet Figueroa Jiménez, María Dolores
Cañete-Massé, Cristina
Carbó-Carreté, Maria
Zarabozo-Hurtado, Daniel
Peró, Maribel
Salazar Estrada, José Guadalupe
Guàrdia-Olmos, Joan, 1958-
author_role author
author2 Cañete-Massé, Cristina
Carbó-Carreté, Maria
Zarabozo-Hurtado, Daniel
Peró, Maribel
Salazar Estrada, José Guadalupe
Guàrdia-Olmos, Joan, 1958-
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Síndrome de Down
Joves discapacitats mentals
Imatges per ressonància magnètica
Mapatge del cervell
Neurologia
Down syndrome
Youth with mental disabilities
Magnetic resonance imaging
Brain mapping
Neurology
topic Síndrome de Down
Joves discapacitats mentals
Imatges per ressonància magnètica
Mapatge del cervell
Neurologia
Down syndrome
Youth with mental disabilities
Magnetic resonance imaging
Brain mapping
Neurology
description Background: Down syndrome (DS) is a chromosomal disorder that causes intellectual disability. Few studies have been conducted on functional connectivity using restingstate fMRI (functional magnetic resonance imaging) signals or more specifically, on the relevant structure and density of the default mode network (DMN). Although data on this issue have been reported in adult DS individuals (age: >45 years), the DMN properties in young DS individuals have not been studied. The aim of this study was to describe the density and structure of the DMN network from fMRI signals in young DS (age: <36 years). Method: A sample of 22 young people with DS between the ages of 16 and 35 (M = 25.5 and SD = 5.1) was recruited in various centers for people with intellectual disability (ID). In addition to sociodemographic data, a six-minute fMRI session was recorded with a 3. T Philips Ingenia scanner. A control group of 22 young people, matched by age and gender, was obtained from the Human Connectome Project (to compare the networks properties between groups). Results: The values of the 48 ROIs that configured the DMN were obtained, and the connectivity graphs for each subject, the average connectivity graph for each group, the clustering and degree values for each ROI, and the average functional connectivity network were estimated. Conclusions: A higher density of overactivation was identified in DS group in the ventral, sensorimotor, and visual DMN networks, although within a framework of a wide variability of connectivity patterns in comparison with the control group network. These results extend our understanding of the functional connectivity networks pattern and intrasubject variability in DS.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/173560
url https://hdl.handle.net/2445/173560
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1002/brb3.1905
Brain and Behavior, 2020, vol. 11, num. 1, p. e01905
https://doi.org/10.1002/brb3.1905
dc.rights.none.fl_str_mv cc-by (c) Figueroa-Jimenez, María Dolores et al., 2020
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Figueroa-Jimenez, María Dolores et al., 2020
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv Articles publicats en revistes (Psicologia Social i Psicologia Quantitativa)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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