Long-Term Exposure to Nitrate and Trihalomethanes in Drinking Water and Gastric Cancer: A Multicase-Control Study in Spain (MCC-Spain)
BACKGROUND: Disinfection byproducts and N-nitroso compounds (NOC) formed endogenously after nitrate ingestion have been shown to be carcinogenic in animal studies, but epidemiological evidence is limited, especially in relation to gastric cancer. OBJECTIVE: We evaluated the association between drink...
| Autores: | , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Recursos: | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| Repositorio: | r-FISABIO. Repositorio Institucional de Producción Científica |
| OAI Identifier: | oai:fisabio.fundanetsuite.com:p20086 |
| Acesso em linha: | https://fisabio.portalinvestigacion.com/publicaciones/20086 https://www.scopus.com/inward/record.uri?eid=2-s2.0-105006687865&doi=10.1289%2fEHP15039&partnerID=40&md5=d721f905d3aa9909aedd9361630a9f7c |
| Access Level: | acceso abierto |
| Palavra-chave: | Adult Aged Case-Control Studies Drinking Water Environmental Exposure Female Humans Male Middle Aged Nitrates Spain Stomach Neoplasms Trihalomethanes Water Pollutants, Chemical alpha tocopherol ascorbic acid bromodichloromethane bromoform chloroform dibromochloromethane drinking water nitrate nitroso derivative trihalomethane water nitric acid derivative adult aged alcohol consumption Article body mass cancer risk case control study cohort analysis controlled study dietary pattern female human interview logistic regression analysis long term exposure major clinical study male metabolic equivalent physical activity primary health care risk factor smoking sociodemographics stomach cancer structured questionnaire water borne disease chemistry environmental exposure epidemiology middle aged stomach tumor toxicity water pollutant |
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Long-Term Exposure to Nitrate and Trihalomethanes in Drinking Water and Gastric Cancer: A Multicase-Control Study in Spain (MCC-Spain) |
| title |
Long-Term Exposure to Nitrate and Trihalomethanes in Drinking Water and Gastric Cancer: A Multicase-Control Study in Spain (MCC-Spain) |
| spellingShingle |
Long-Term Exposure to Nitrate and Trihalomethanes in Drinking Water and Gastric Cancer: A Multicase-Control Study in Spain (MCC-Spain) Donat-Vargas, C Adult Aged Case-Control Studies Drinking Water Environmental Exposure Female Humans Male Middle Aged Nitrates Spain Stomach Neoplasms Trihalomethanes Water Pollutants, Chemical alpha tocopherol ascorbic acid bromodichloromethane bromoform chloroform dibromochloromethane drinking water nitrate nitroso derivative trihalomethane water nitric acid derivative trihalomethane adult aged alcohol consumption Article body mass cancer risk case control study cohort analysis controlled study dietary pattern female human interview logistic regression analysis long term exposure major clinical study male metabolic equivalent physical activity primary health care risk factor smoking sociodemographics Spain stomach cancer structured questionnaire water borne disease chemistry environmental exposure epidemiology middle aged stomach tumor toxicity water pollutant |
| title_short |
Long-Term Exposure to Nitrate and Trihalomethanes in Drinking Water and Gastric Cancer: A Multicase-Control Study in Spain (MCC-Spain) |
| title_full |
Long-Term Exposure to Nitrate and Trihalomethanes in Drinking Water and Gastric Cancer: A Multicase-Control Study in Spain (MCC-Spain) |
| title_fullStr |
Long-Term Exposure to Nitrate and Trihalomethanes in Drinking Water and Gastric Cancer: A Multicase-Control Study in Spain (MCC-Spain) |
| title_full_unstemmed |
Long-Term Exposure to Nitrate and Trihalomethanes in Drinking Water and Gastric Cancer: A Multicase-Control Study in Spain (MCC-Spain) |
| title_sort |
Long-Term Exposure to Nitrate and Trihalomethanes in Drinking Water and Gastric Cancer: A Multicase-Control Study in Spain (MCC-Spain) |
| dc.creator.none.fl_str_mv |
Donat-Vargas, C Kogevinas, M Castaño-Vinyals, G Pérez-Gómez, B Aragonés, N Guevara, M Gómez-Acebo, I Molina, A Fernandez-Tardon, G Vanaclocha-Espí, M Molina-Barceló, A Moreno, V Pollan, M Villanueva, CM |
| author |
Donat-Vargas, C |
| author_facet |
Donat-Vargas, C Kogevinas, M Castaño-Vinyals, G Pérez-Gómez, B Aragonés, N Guevara, M Gómez-Acebo, I Molina, A Fernandez-Tardon, G Vanaclocha-Espí, M Molina-Barceló, A Moreno, V Pollan, M Villanueva, CM |
| author_role |
author |
| author2 |
Kogevinas, M Castaño-Vinyals, G Pérez-Gómez, B Aragonés, N Guevara, M Gómez-Acebo, I Molina, A Fernandez-Tardon, G Vanaclocha-Espí, M Molina-Barceló, A Moreno, V Pollan, M Villanueva, CM |
| author2_role |
author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Adult Aged Case-Control Studies Drinking Water Environmental Exposure Female Humans Male Middle Aged Nitrates Spain Stomach Neoplasms Trihalomethanes Water Pollutants, Chemical alpha tocopherol ascorbic acid bromodichloromethane bromoform chloroform dibromochloromethane drinking water nitrate nitroso derivative trihalomethane water nitric acid derivative trihalomethane adult aged alcohol consumption Article body mass cancer risk case control study cohort analysis controlled study dietary pattern female human interview logistic regression analysis long term exposure major clinical study male metabolic equivalent physical activity primary health care risk factor smoking sociodemographics Spain stomach cancer structured questionnaire water borne disease chemistry environmental exposure epidemiology middle aged stomach tumor toxicity water pollutant |
| topic |
Adult Aged Case-Control Studies Drinking Water Environmental Exposure Female Humans Male Middle Aged Nitrates Spain Stomach Neoplasms Trihalomethanes Water Pollutants, Chemical alpha tocopherol ascorbic acid bromodichloromethane bromoform chloroform dibromochloromethane drinking water nitrate nitroso derivative trihalomethane water nitric acid derivative trihalomethane adult aged alcohol consumption Article body mass cancer risk case control study cohort analysis controlled study dietary pattern female human interview logistic regression analysis long term exposure major clinical study male metabolic equivalent physical activity primary health care risk factor smoking sociodemographics Spain stomach cancer structured questionnaire water borne disease chemistry environmental exposure epidemiology middle aged stomach tumor toxicity water pollutant |
| description |
BACKGROUND: Disinfection byproducts and N-nitroso compounds (NOC) formed endogenously after nitrate ingestion have been shown to be carcinogenic in animal studies, but epidemiological evidence is limited, especially in relation to gastric cancer. OBJECTIVE: We evaluated the association between drinking water exposure to nitrate and trihalomethanes (THMs) and gastric cancer in a multicasecontrol study conducted in Spain (MCC-Spain). METHODS: In 20082013, 254 hospital-based incident gastric cancer cases and 2,365 population-based controls were recruited, providing information on residential histories and type of water consumed. Adult lifetime average nitrate and THM levels in residences from age 18 until 2 years before the interview were estimated and linked with water consumption information to calculate waterborne ingested nitrate, brominated (Br)-THMs, and chloroform. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression, with adjustment for potential confounders. We assessed the effect modification by factors influencing endogenous NOC formation. RESULTS: Median [percentile 25th (P-25)percentile 75 (P-75)] (P25-P75) lifetime waterborne ingested nitrate (mg/day), Br-THMs (mu g/day), and chloroform (mu g/day) were 2.7 (1.45.6), 3.8 (1.58.1), and 12.2 (4.023.7), respectively, in cases and 3.8 (1.88.5), 5.7 (2.619.2), and 12.9 (4.624.5) in controls, respectively. Adjusted OR (95% CI) for gastric cancer comparing nitrate intake >9.7 vs. <= 9.7mg/day (percentile 80th, P-80) was 1.42 (0.88, 2.29). This association was more pronounced among participants with low consumption of vegetables [2.24 (1.02, 4.91)], vitamin C [2.10 (0.94, 4.71)], and vitamin E [2.81 (1.16, 6.78)] and among those with high consumption of alcohol [2.78 (0.98, 7.93)] or processed meat [1.91 (0.97, 3.75)]. When stratified by age, the association only remained in the >65 years of age group (median 73 years of age). OR for gastric cancer comparing Br-THM ingestion = vs. 80th <80th percentile was 0.65 (0.33, 1.28) and for chloroform was 1.36 (0.87, 2.14). Comparable ORs were found for residential concentrations. CONCLUSIONS: Long-term waterborne nitrate exposure below regulatory limits may increase gastric cancer risk among older adults and in those with poor dietary patterns. These findings need to be confirmed by cohort studies with larger sample sizes. https://doi.org/10.1289/EHP15039 |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://fisabio.portalinvestigacion.com/publicaciones/20086 https://www.scopus.com/inward/record.uri?eid=2-s2.0-105006687865&doi=10.1289%2fEHP15039&partnerID=40&md5=d721f905d3aa9909aedd9361630a9f7c |
| url |
https://fisabio.portalinvestigacion.com/publicaciones/20086 https://www.scopus.com/inward/record.uri?eid=2-s2.0-105006687865&doi=10.1289%2fEHP15039&partnerID=40&md5=d721f905d3aa9909aedd9361630a9f7c |
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Inglés |
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Inglés |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.publisher.none.fl_str_mv |
US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE |
| publisher.none.fl_str_mv |
US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE |
| dc.source.none.fl_str_mv |
ENVIRONMENTAL HEALTH PERSPECTIVES ISSN: 00916765 ISSNe: 15529924 reponame:r-FISABIO. Repositorio Institucional de Producción Científica instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
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Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
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r-FISABIO. Repositorio Institucional de Producción Científica |
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r-FISABIO. Repositorio Institucional de Producción Científica |
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1869424643500146688 |
| spelling |
Long-Term Exposure to Nitrate and Trihalomethanes in Drinking Water and Gastric Cancer: A Multicase-Control Study in Spain (MCC-Spain)Donat-Vargas, CKogevinas, MCastaño-Vinyals, GPérez-Gómez, BAragonés, NGuevara, MGómez-Acebo, IMolina, AFernandez-Tardon, GVanaclocha-Espí, MMolina-Barceló, AMoreno, VPollan, MVillanueva, CMAdultAgedCase-Control StudiesDrinking WaterEnvironmental ExposureFemaleHumansMaleMiddle AgedNitratesSpainStomach NeoplasmsTrihalomethanesWater Pollutants, Chemicalalpha tocopherolascorbic acidbromodichloromethanebromoformchloroformdibromochloromethanedrinking waternitratenitroso derivativetrihalomethanewaternitric acid derivativetrihalomethaneadultagedalcohol consumptionArticlebody masscancer riskcase control studycohort analysiscontrolled studydietary patternfemalehumaninterviewlogistic regression analysislong term exposuremajor clinical studymalemetabolic equivalentphysical activityprimary health carerisk factorsmokingsociodemographicsSpainstomach cancerstructured questionnairewater borne diseasechemistryenvironmental exposureepidemiologymiddle agedstomach tumortoxicitywater pollutantBACKGROUND: Disinfection byproducts and N-nitroso compounds (NOC) formed endogenously after nitrate ingestion have been shown to be carcinogenic in animal studies, but epidemiological evidence is limited, especially in relation to gastric cancer. OBJECTIVE: We evaluated the association between drinking water exposure to nitrate and trihalomethanes (THMs) and gastric cancer in a multicasecontrol study conducted in Spain (MCC-Spain). METHODS: In 20082013, 254 hospital-based incident gastric cancer cases and 2,365 population-based controls were recruited, providing information on residential histories and type of water consumed. Adult lifetime average nitrate and THM levels in residences from age 18 until 2 years before the interview were estimated and linked with water consumption information to calculate waterborne ingested nitrate, brominated (Br)-THMs, and chloroform. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression, with adjustment for potential confounders. We assessed the effect modification by factors influencing endogenous NOC formation. RESULTS: Median [percentile 25th (P-25)percentile 75 (P-75)] (P25-P75) lifetime waterborne ingested nitrate (mg/day), Br-THMs (mu g/day), and chloroform (mu g/day) were 2.7 (1.45.6), 3.8 (1.58.1), and 12.2 (4.023.7), respectively, in cases and 3.8 (1.88.5), 5.7 (2.619.2), and 12.9 (4.624.5) in controls, respectively. Adjusted OR (95% CI) for gastric cancer comparing nitrate intake >9.7 vs. <= 9.7mg/day (percentile 80th, P-80) was 1.42 (0.88, 2.29). This association was more pronounced among participants with low consumption of vegetables [2.24 (1.02, 4.91)], vitamin C [2.10 (0.94, 4.71)], and vitamin E [2.81 (1.16, 6.78)] and among those with high consumption of alcohol [2.78 (0.98, 7.93)] or processed meat [1.91 (0.97, 3.75)]. When stratified by age, the association only remained in the >65 years of age group (median 73 years of age). OR for gastric cancer comparing Br-THM ingestion = vs. 80th <80th percentile was 0.65 (0.33, 1.28) and for chloroform was 1.36 (0.87, 2.14). Comparable ORs were found for residential concentrations. CONCLUSIONS: Long-term waterborne nitrate exposure below regulatory limits may increase gastric cancer risk among older adults and in those with poor dietary patterns. These findings need to be confirmed by cohort studies with larger sample sizes. https://doi.org/10.1289/EHP15039US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/20086https://www.scopus.com/inward/record.uri?eid=2-s2.0-105006687865&doi=10.1289%2fEHP15039&partnerID=40&md5=d721f905d3aa9909aedd9361630a9f7cENVIRONMENTAL HEALTH PERSPECTIVESISSN: 00916765ISSNe: 15529924reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p200862026-06-11T12:45:17Z |
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15.811543 |