Bipolar disorder comorbid with alcohol use disorder: Focus on neurocognitive correlates

Bipolar disorder (BD) and alcohol use disorders (AUDs) are usually comorbid, and both have been associated with significant neurocognitive impairment. Patients with the BD-AUD comorbidity (dual diagnosis) may have more severe neurocognitive deficits than those with a single diagnosis, but there is p...

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Detalhes bibliográficos
Autores: Balanzá Martínez, Vicent, Crespo Facorro, Benedicto, González Pinto Arrillaga, Ana María, Vieta, Eduard
Formato: artículo
Fecha de publicación:2015
País:España
Recursos:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/16139
Acesso em linha:http://hdl.handle.net/10810/16139
Access Level:acceso abierto
Palavra-chave:bipolar disorder
comorbidity
addiction
alcohol use disorders
neurocognition
staging
systems biology
PHYSIOLOGY
PHYSIOLOGY (MEDICAL)
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spelling Bipolar disorder comorbid with alcohol use disorder: Focus on neurocognitive correlatesBalanzá Martínez, VicentCrespo Facorro, BenedictoGonzález Pinto Arrillaga, Ana MaríaVieta, Eduardbipolar disordercomorbidityaddictionalcohol use disordersneurocognitionstagingsystems biologyPHYSIOLOGYPHYSIOLOGY (MEDICAL)Bipolar disorder (BD) and alcohol use disorders (AUDs) are usually comorbid, and both have been associated with significant neurocognitive impairment. Patients with the BD-AUD comorbidity (dual diagnosis) may have more severe neurocognitive deficits than those with a single diagnosis, but there is paucity of research in this area. To explore this hypothesis more thoroughly, we carried out a systematic literature review through January 2015. Eight studies have examined the effect of AUDs on the neurocognitive functioning of BD patients. Most studies found that BD patients with current or past history of comorbid AUDs show more severe impairments, especially in verbal memory and executive cognition, than their non-dual counterparts. Greater neurocognitive dysfunction is another facet of this severe comorbid presentation. Implications for clinical practice and research are discussed. Specifically, the application of holistic approaches, such as clinical staging and systems biology, may open new avenues of discoveries related to the BD-AUD comorbidity.The authors of this report would like to acknowledge the support of the Spanish Ministry of Economy and Competitiveness, Instituto de Salud Carlos III (ISCIII), CIBERSAM. This work was sponsored by a national grant PI14/00894 which belongs to the Spanish “Plan Nacional de I+D+I 2013-2016” and is co-funded by the “ISCIII-Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER).”Frontiers Research Foundation201520152015info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/16139reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttp://journal.frontiersin.org/article/10.3389/fphys.2015.00108/abstractinfo:eu-repo/semantics/openAccess© 2015 Balanzá-Martínez, Crespo-Facorro, González-Pinto and Vieta. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.oai:addi.ehu.eus:10810/161392026-06-18T09:23:17Z
dc.title.none.fl_str_mv Bipolar disorder comorbid with alcohol use disorder: Focus on neurocognitive correlates
title Bipolar disorder comorbid with alcohol use disorder: Focus on neurocognitive correlates
spellingShingle Bipolar disorder comorbid with alcohol use disorder: Focus on neurocognitive correlates
Balanzá Martínez, Vicent
bipolar disorder
comorbidity
addiction
alcohol use disorders
neurocognition
staging
systems biology
PHYSIOLOGY
PHYSIOLOGY (MEDICAL)
title_short Bipolar disorder comorbid with alcohol use disorder: Focus on neurocognitive correlates
title_full Bipolar disorder comorbid with alcohol use disorder: Focus on neurocognitive correlates
title_fullStr Bipolar disorder comorbid with alcohol use disorder: Focus on neurocognitive correlates
title_full_unstemmed Bipolar disorder comorbid with alcohol use disorder: Focus on neurocognitive correlates
title_sort Bipolar disorder comorbid with alcohol use disorder: Focus on neurocognitive correlates
dc.creator.none.fl_str_mv Balanzá Martínez, Vicent
Crespo Facorro, Benedicto
González Pinto Arrillaga, Ana María
Vieta, Eduard
author Balanzá Martínez, Vicent
author_facet Balanzá Martínez, Vicent
Crespo Facorro, Benedicto
González Pinto Arrillaga, Ana María
Vieta, Eduard
author_role author
author2 Crespo Facorro, Benedicto
González Pinto Arrillaga, Ana María
Vieta, Eduard
author2_role author
author
author
dc.subject.none.fl_str_mv bipolar disorder
comorbidity
addiction
alcohol use disorders
neurocognition
staging
systems biology
PHYSIOLOGY
PHYSIOLOGY (MEDICAL)
topic bipolar disorder
comorbidity
addiction
alcohol use disorders
neurocognition
staging
systems biology
PHYSIOLOGY
PHYSIOLOGY (MEDICAL)
description Bipolar disorder (BD) and alcohol use disorders (AUDs) are usually comorbid, and both have been associated with significant neurocognitive impairment. Patients with the BD-AUD comorbidity (dual diagnosis) may have more severe neurocognitive deficits than those with a single diagnosis, but there is paucity of research in this area. To explore this hypothesis more thoroughly, we carried out a systematic literature review through January 2015. Eight studies have examined the effect of AUDs on the neurocognitive functioning of BD patients. Most studies found that BD patients with current or past history of comorbid AUDs show more severe impairments, especially in verbal memory and executive cognition, than their non-dual counterparts. Greater neurocognitive dysfunction is another facet of this severe comorbid presentation. Implications for clinical practice and research are discussed. Specifically, the application of holistic approaches, such as clinical staging and systems biology, may open new avenues of discoveries related to the BD-AUD comorbidity.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/16139
url http://hdl.handle.net/10810/16139
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://journal.frontiersin.org/article/10.3389/fphys.2015.00108/abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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