Sexual dimorphism in brown adipose tissue activation and white adipose tissue browning

The present narrative review gathers the studies reported so far, addressing sex differences in the effects of cold exposure, feeding pattern and age on brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning. In rodents, when exposed to decreasing temperatures, females acti...

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Autores: Gómez-García, Iker, Trepiana, Jenifer, Fernández-Quintela, Alfredo, Giralt i Oms, Marta, Portillo, María Puy
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/192990
Acceso en línea:https://hdl.handle.net/2445/192990
Access Level:acceso abierto
Palabra clave:Dimorfisme sexual en els animals
Teixit adipós
Hormones sexuals
Sexual dimorphism (Animals)
Adipose tissues
Sex hormones
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spelling Sexual dimorphism in brown adipose tissue activation and white adipose tissue browningGómez-García, IkerTrepiana, JeniferFernández-Quintela, AlfredoGiralt i Oms, MartaPortillo, María PuyDimorfisme sexual en els animalsTeixit adipósHormones sexualsSexual dimorphism (Animals)Adipose tissuesSex hormonesThe present narrative review gathers the studies reported so far, addressing sex differences in the effects of cold exposure, feeding pattern and age on brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning. In rodents, when exposed to decreasing temperatures, females activate thermogenesis earlier. Results obtained in humans go in the same line, although they do not provide results as solid as those obtained in rodents. Regarding the effects of overfeeding, interesting sex differences on BAT thermogenic capacity have been reported, and the greater or lower sensitivity of each sex to this dietary situation seems to be dependent on the type of feeding. In the case of energy restriction, females are more sensitive than males. In addition, sex differences have also been observed in thermogenesis changes induced by phenolic compound administration. During sexual development, an increase in BAT mass and BAT activity takes place. This phenomenon is greater in boys than in girls, probably due to its relation to muscle-mass growth. The opposite situation takes place during ageing, a lifespan period where thermogenic capacity declines, this being more acute in men than in women. Finally, the vast majority of the studies have reported a higher susceptibility to developing WAT browning amongst females. The scarcity of results highlights the need for further studies devoted to analysing this issue, in order to provide valuable information for a more personalised approach.MDPI2023202320222023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion23 p.application/pdfhttps://hdl.handle.net/2445/192990Articles publicats en revistes (Bioquímica i Biomedicina Molecular)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/ijms23158250International Journal of Molecular Sciences, 2022, vol. 23, num. 15, p. 8250https://doi.org/10.3390/ijms23158250cc-by (c) Gómez-García, Iker et al., 2022https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1929902026-05-29T05:05:01Z
dc.title.none.fl_str_mv Sexual dimorphism in brown adipose tissue activation and white adipose tissue browning
title Sexual dimorphism in brown adipose tissue activation and white adipose tissue browning
spellingShingle Sexual dimorphism in brown adipose tissue activation and white adipose tissue browning
Gómez-García, Iker
Dimorfisme sexual en els animals
Teixit adipós
Hormones sexuals
Sexual dimorphism (Animals)
Adipose tissues
Sex hormones
title_short Sexual dimorphism in brown adipose tissue activation and white adipose tissue browning
title_full Sexual dimorphism in brown adipose tissue activation and white adipose tissue browning
title_fullStr Sexual dimorphism in brown adipose tissue activation and white adipose tissue browning
title_full_unstemmed Sexual dimorphism in brown adipose tissue activation and white adipose tissue browning
title_sort Sexual dimorphism in brown adipose tissue activation and white adipose tissue browning
dc.creator.none.fl_str_mv Gómez-García, Iker
Trepiana, Jenifer
Fernández-Quintela, Alfredo
Giralt i Oms, Marta
Portillo, María Puy
author Gómez-García, Iker
author_facet Gómez-García, Iker
Trepiana, Jenifer
Fernández-Quintela, Alfredo
Giralt i Oms, Marta
Portillo, María Puy
author_role author
author2 Trepiana, Jenifer
Fernández-Quintela, Alfredo
Giralt i Oms, Marta
Portillo, María Puy
author2_role author
author
author
author
dc.subject.none.fl_str_mv Dimorfisme sexual en els animals
Teixit adipós
Hormones sexuals
Sexual dimorphism (Animals)
Adipose tissues
Sex hormones
topic Dimorfisme sexual en els animals
Teixit adipós
Hormones sexuals
Sexual dimorphism (Animals)
Adipose tissues
Sex hormones
description The present narrative review gathers the studies reported so far, addressing sex differences in the effects of cold exposure, feeding pattern and age on brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning. In rodents, when exposed to decreasing temperatures, females activate thermogenesis earlier. Results obtained in humans go in the same line, although they do not provide results as solid as those obtained in rodents. Regarding the effects of overfeeding, interesting sex differences on BAT thermogenic capacity have been reported, and the greater or lower sensitivity of each sex to this dietary situation seems to be dependent on the type of feeding. In the case of energy restriction, females are more sensitive than males. In addition, sex differences have also been observed in thermogenesis changes induced by phenolic compound administration. During sexual development, an increase in BAT mass and BAT activity takes place. This phenomenon is greater in boys than in girls, probably due to its relation to muscle-mass growth. The opposite situation takes place during ageing, a lifespan period where thermogenic capacity declines, this being more acute in men than in women. Finally, the vast majority of the studies have reported a higher susceptibility to developing WAT browning amongst females. The scarcity of results highlights the need for further studies devoted to analysing this issue, in order to provide valuable information for a more personalised approach.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/192990
url https://hdl.handle.net/2445/192990
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/ijms23158250
International Journal of Molecular Sciences, 2022, vol. 23, num. 15, p. 8250
https://doi.org/10.3390/ijms23158250
dc.rights.none.fl_str_mv cc-by (c) Gómez-García, Iker et al., 2022
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Gómez-García, Iker et al., 2022
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 23 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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