Evaluation of the potential of a quinidine-based monolithic column on the enantiomeric separation of herbicides by nano-liquid chromatography

The use of agrochemicals as pure enantiomers avoids the presence of non-active pesticide compounds in the environment. The quality control of these agrochemicals requires the development of new chiral methodologies. In this work, the performance of the monolithic column named poly(O-9-[2-(methacrylo...

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Autores: Zhang, Q., Gil Toro, Verónica Cielo, Sánchez López, Elena, García González, María Ángeles|||0000-0001-6292-8232, Jiang, Z., Marina Alegre, María Luisa|||0000-0002-5583-1624
Formato: artículo
Fecha de publicación:2015
País:España
Recursos:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/48229
Acesso em linha:http://hdl.handle.net/10017/48229
https://dx.doi.org/10.1016/j.microc.2015.05.011
Access Level:acceso abierto
Palavra-chave:Chiral separation
Phenoxy acid herbicide
Mecoprop
Nano-liquid chromatography
Quinidine monolithic column
Química
Chemistry
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spelling Evaluation of the potential of a quinidine-based monolithic column on the enantiomeric separation of herbicides by nano-liquid chromatographyZhang, Q.Gil Toro, Verónica CieloSánchez López, ElenaGarcía González, María Ángeles|||0000-0001-6292-8232Jiang, Z.Marina Alegre, María Luisa|||0000-0002-5583-1624Chiral separationPhenoxy acid herbicideMecopropNano-liquid chromatographyQuinidine monolithic columnQuímicaChemistryThe use of agrochemicals as pure enantiomers avoids the presence of non-active pesticide compounds in the environment. The quality control of these agrochemicals requires the development of new chiral methodologies. In this work, the performance of the monolithic column named poly(O-9-[2-(methacryloyloxy)-ethylcarbamoyl]-10,11-dihydroquinidine-co-2-hydroxyethyl methacrylate-co-ethylene dimethacrylate) (poly(MQD-co-HEMA-co-EDMA)) was assessed as stationary phase for the enantiomeric separation of seven phenoxy acid herbicides (dichlorprop, 2-(4-chlorophenoxy)propionic acid, 2-(3-chlorophenoxy)propionic acid, mecoprop, fenoprop, 2-phenoxypropionic acid, and fenoxaprop) in a nano-liquid chromatography (nano-LC) system. Under optimized conditions (60/40 (v/v) ACN/0.1 M ammonium acetate (pH 6.0) at a flow rate of 20 mu L/min), it was possible to obtain baseline separation for most of the studied compounds. The analysis of an enantiomerically pure mecoprop commercial herbicide sample which also contained three achiral phenoxy acid herbicides (MCPA, 2,4-D and dicamba) commonly present in these kinds of formulations showed that the use of a 80/20 (v/v) ACN/0.1 M ammonium acetate (pH 5.3) enabled the simultaneous separation of these compounds and mecoprop enantiomers in less than 8 min. The analytical characteristics of the methodology were evaluated in terms of selectivity, linearity, precision, accuracy, LOD, and LOQ Results demonstrated that determined amounts of R-mecoprop in commercial formulations were in agreement with the labeled content and the enantiomeric impurity was below the LOQ, The poly(MQD-co-HEMA-co-EDMA) capillary monolithic column exhibits great potential as a useful and environmental-friendly tool for the quality control of agrochemicals by nano-LC. (C) 2015 Elsevier B.V. All rights reserved.Ministerio de Economía y Competitividad20152015-11-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/48229https://dx.doi.org/10.1016/j.microc.2015.05.011reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Not available CTQ2013-48740-P METODOLOGIAS AVANZADAS PARA ANALISIS QUIRAL MEDIANTE TECNICAS MICROSEPARATIVAS. BUSQUEDA DE BIOMARCADORES EN SISTEMAS ENANTIOSELECTIVOSopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-ShareAlike 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/482292026-06-18T11:13:07Z
dc.title.none.fl_str_mv Evaluation of the potential of a quinidine-based monolithic column on the enantiomeric separation of herbicides by nano-liquid chromatography
title Evaluation of the potential of a quinidine-based monolithic column on the enantiomeric separation of herbicides by nano-liquid chromatography
spellingShingle Evaluation of the potential of a quinidine-based monolithic column on the enantiomeric separation of herbicides by nano-liquid chromatography
Zhang, Q.
Chiral separation
Phenoxy acid herbicide
Mecoprop
Nano-liquid chromatography
Quinidine monolithic column
Química
Chemistry
title_short Evaluation of the potential of a quinidine-based monolithic column on the enantiomeric separation of herbicides by nano-liquid chromatography
title_full Evaluation of the potential of a quinidine-based monolithic column on the enantiomeric separation of herbicides by nano-liquid chromatography
title_fullStr Evaluation of the potential of a quinidine-based monolithic column on the enantiomeric separation of herbicides by nano-liquid chromatography
title_full_unstemmed Evaluation of the potential of a quinidine-based monolithic column on the enantiomeric separation of herbicides by nano-liquid chromatography
title_sort Evaluation of the potential of a quinidine-based monolithic column on the enantiomeric separation of herbicides by nano-liquid chromatography
dc.creator.none.fl_str_mv Zhang, Q.
Gil Toro, Verónica Cielo
Sánchez López, Elena
García González, María Ángeles|||0000-0001-6292-8232
Jiang, Z.
Marina Alegre, María Luisa|||0000-0002-5583-1624
author Zhang, Q.
author_facet Zhang, Q.
Gil Toro, Verónica Cielo
Sánchez López, Elena
García González, María Ángeles|||0000-0001-6292-8232
Jiang, Z.
Marina Alegre, María Luisa|||0000-0002-5583-1624
author_role author
author2 Gil Toro, Verónica Cielo
Sánchez López, Elena
García González, María Ángeles|||0000-0001-6292-8232
Jiang, Z.
Marina Alegre, María Luisa|||0000-0002-5583-1624
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Chiral separation
Phenoxy acid herbicide
Mecoprop
Nano-liquid chromatography
Quinidine monolithic column
Química
Chemistry
topic Chiral separation
Phenoxy acid herbicide
Mecoprop
Nano-liquid chromatography
Quinidine monolithic column
Química
Chemistry
description The use of agrochemicals as pure enantiomers avoids the presence of non-active pesticide compounds in the environment. The quality control of these agrochemicals requires the development of new chiral methodologies. In this work, the performance of the monolithic column named poly(O-9-[2-(methacryloyloxy)-ethylcarbamoyl]-10,11-dihydroquinidine-co-2-hydroxyethyl methacrylate-co-ethylene dimethacrylate) (poly(MQD-co-HEMA-co-EDMA)) was assessed as stationary phase for the enantiomeric separation of seven phenoxy acid herbicides (dichlorprop, 2-(4-chlorophenoxy)propionic acid, 2-(3-chlorophenoxy)propionic acid, mecoprop, fenoprop, 2-phenoxypropionic acid, and fenoxaprop) in a nano-liquid chromatography (nano-LC) system. Under optimized conditions (60/40 (v/v) ACN/0.1 M ammonium acetate (pH 6.0) at a flow rate of 20 mu L/min), it was possible to obtain baseline separation for most of the studied compounds. The analysis of an enantiomerically pure mecoprop commercial herbicide sample which also contained three achiral phenoxy acid herbicides (MCPA, 2,4-D and dicamba) commonly present in these kinds of formulations showed that the use of a 80/20 (v/v) ACN/0.1 M ammonium acetate (pH 5.3) enabled the simultaneous separation of these compounds and mecoprop enantiomers in less than 8 min. The analytical characteristics of the methodology were evaluated in terms of selectivity, linearity, precision, accuracy, LOD, and LOQ Results demonstrated that determined amounts of R-mecoprop in commercial formulations were in agreement with the labeled content and the enantiomeric impurity was below the LOQ, The poly(MQD-co-HEMA-co-EDMA) capillary monolithic column exhibits great potential as a useful and environmental-friendly tool for the quality control of agrochemicals by nano-LC. (C) 2015 Elsevier B.V. All rights reserved.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-11-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/48229
https://dx.doi.org/10.1016/j.microc.2015.05.011
url http://hdl.handle.net/10017/48229
https://dx.doi.org/10.1016/j.microc.2015.05.011
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Not available CTQ2013-48740-P METODOLOGIAS AVANZADAS PARA ANALISIS QUIRAL MEDIANTE TECNICAS MICROSEPARATIVAS. BUSQUEDA DE BIOMARCADORES EN SISTEMAS ENANTIOSELECTIVOS
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-ShareAlike 4.0 International
http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-ShareAlike 4.0 International
http://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
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repository.mail.fl_str_mv
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