Supercritical technology applied to the development of drug delivery systems for bone regeneration

Bone is the second most transplanted tissue, only behind blood transfusions, with over 2 million of procedures worldwide each year. This number is expected to increase, given that ageing is a risk factor for fractures and fracture delayed union and non-union, that currently reach up to 10 % of cases...

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Detalles Bibliográficos
Autor: Goimil García, Leticia
Tipo de recurso: tesis doctoral
Fecha de publicación:2019
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/19770
Acceso en línea:http://hdl.handle.net/10347/19770
Access Level:acceso abierto
Palabra clave:Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320902 Composición de medicamentos
Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320908 Preparación de medicamentos
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spelling Supercritical technology applied to the development of drug delivery systems for bone regenerationGoimil García, LeticiaMaterias::Investigación::32 Ciencias médicas::3209 Farmacología::320902 Composición de medicamentosMaterias::Investigación::32 Ciencias médicas::3209 Farmacología::320908 Preparación de medicamentosBone is the second most transplanted tissue, only behind blood transfusions, with over 2 million of procedures worldwide each year. This number is expected to increase, given that ageing is a risk factor for fractures and fracture delayed union and non-union, that currently reach up to 10 % of cases. Different approaches have been proposed with the purpose of obtaining synthetic scaffolds that can be used as bone grafts. In this Thesis, supercritical fluids were employed to optimize the preparation of synthetic scaffolds made of two biocompatible and biodegradable polymers, poly(lactic-co-glycolic acid) (PLGA) and poly(e-caprolactone) (PCL), with the incorporation of aerogel microparticles and anti-inflammatories as bioactive compounds in order to improve their properties for their application as bone grafts. The scaffolds were tested regarding their textural, phisicochemical and mechanical properties, degradation rates, drug release profiles, stability in storage and performance in an animal model.Álvarez Lorenzo, CarmenGarcía González, Carlos A.Universidade de Santiago de Compostela. Centro Internacional de Estudos de Doutoramento e Avanzados (CIEDUS)Universidade de Santiago de Compostela. Escola de Doutoramento Internacional en Ciencias da Saúde20192019-01-0120192019-01-01doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttp://hdl.handle.net/10347/19770reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/197702026-06-15T12:47:27Z
dc.title.none.fl_str_mv Supercritical technology applied to the development of drug delivery systems for bone regeneration
title Supercritical technology applied to the development of drug delivery systems for bone regeneration
spellingShingle Supercritical technology applied to the development of drug delivery systems for bone regeneration
Goimil García, Leticia
Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320902 Composición de medicamentos
Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320908 Preparación de medicamentos
title_short Supercritical technology applied to the development of drug delivery systems for bone regeneration
title_full Supercritical technology applied to the development of drug delivery systems for bone regeneration
title_fullStr Supercritical technology applied to the development of drug delivery systems for bone regeneration
title_full_unstemmed Supercritical technology applied to the development of drug delivery systems for bone regeneration
title_sort Supercritical technology applied to the development of drug delivery systems for bone regeneration
dc.creator.none.fl_str_mv Goimil García, Leticia
author Goimil García, Leticia
author_facet Goimil García, Leticia
author_role author
dc.contributor.none.fl_str_mv Álvarez Lorenzo, Carmen
García González, Carlos A.
Universidade de Santiago de Compostela. Centro Internacional de Estudos de Doutoramento e Avanzados (CIEDUS)
Universidade de Santiago de Compostela. Escola de Doutoramento Internacional en Ciencias da Saúde
dc.subject.none.fl_str_mv Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320902 Composición de medicamentos
Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320908 Preparación de medicamentos
topic Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320902 Composición de medicamentos
Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320908 Preparación de medicamentos
description Bone is the second most transplanted tissue, only behind blood transfusions, with over 2 million of procedures worldwide each year. This number is expected to increase, given that ageing is a risk factor for fractures and fracture delayed union and non-union, that currently reach up to 10 % of cases. Different approaches have been proposed with the purpose of obtaining synthetic scaffolds that can be used as bone grafts. In this Thesis, supercritical fluids were employed to optimize the preparation of synthetic scaffolds made of two biocompatible and biodegradable polymers, poly(lactic-co-glycolic acid) (PLGA) and poly(e-caprolactone) (PCL), with the incorporation of aerogel microparticles and anti-inflammatories as bioactive compounds in order to improve their properties for their application as bone grafts. The scaffolds were tested regarding their textural, phisicochemical and mechanical properties, degradation rates, drug release profiles, stability in storage and performance in an animal model.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv http://hdl.handle.net/10347/19770
url http://hdl.handle.net/10347/19770
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
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