Immune response and partial protection against heterologous foot-and-mouth disease virus induced by dendrimer peptides in cattle

Synthetic peptides mimicking protective B- and T-cell epitopes are good candidates for safer, more effective FMD vaccines. Nevertheless, previous studies of immunization with linear peptides showed that they failed to induce solid protection in cattle. Dendrimeric peptides displaying two or four cop...

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Detalles Bibliográficos
Autores: Soria, Ivana, Quattrocchi, Valeria, Langellotti, Cecilia, Pérez-Filgueira, Mariano, Pega, J., Gnazzo, V., Romera, S., Schammas, J., Bucafusco, D., Di Giacomo, S., Torre, Beatriz G. de la, Andreu Martínez, David, Sobrino, Francisco, Blanco, Esther, Zamorano, Patricia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/35676
Acceso en línea:http://hdl.handle.net/10230/35676
http://dx.doi.org/10.1155/2018/3497401
Access Level:acceso abierto
Palabra clave:Foot-and-mouth disease
Dendrimers
Peptides
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spelling Immune response and partial protection against heterologous foot-and-mouth disease virus induced by dendrimer peptides in cattleSoria, IvanaQuattrocchi, ValeriaLangellotti, CeciliaPérez-Filgueira, MarianoPega, J.Gnazzo, V.Romera, S.Schammas, J.Bucafusco, D.Di Giacomo, S.Torre, Beatriz G. de laAndreu Martínez, DavidSobrino, FranciscoBlanco, EstherZamorano, PatriciaFoot-and-mouth diseaseDendrimersPeptidesSynthetic peptides mimicking protective B- and T-cell epitopes are good candidates for safer, more effective FMD vaccines. Nevertheless, previous studies of immunization with linear peptides showed that they failed to induce solid protection in cattle. Dendrimeric peptides displaying two or four copies of a peptide corresponding to the B-cell epitope VP1 [136-154] of type O FMDV (O/UKG/11/2001) linked through thioether bonds to a single copy of the T-cell epitope 3A [21-35] (termed B2T and B4T, resp.) afforded protection in vaccinated pigs. In this work, we show that dendrimeric peptides B2T and B4T can elicit specific humoral responses in cattle and confer partial protection against the challenge with a heterologous type O virus (O1/Campos/Bra/58). This protective response correlated with the induction of specific T-cells as well as with an anamnestic antibody response upon virus challenge, as shown by the detection of virus-specific antibody-secreting cells (ASC) in lymphoid tissues distal from the inoculation pointWork at INTA was supported by the National Institute of Agricultural Technology (Grant no. PNSA 1115052) and an INTA-INIA (Spain) cooperation agreement. Work at UPF and CBMSO was supported by MINECO, Spain (Grant no. AGL2014-52395-C2)Hindawi201820182018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/35676http://dx.doi.org/10.1155/2018/3497401reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésJournal of Immunology Research. 2018;2018:3497401info:eu-repo/grantAgreement/ES/1PE/AGL2014-52395-C2© 2018 I. Soria et al. This is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/356762026-05-29T05:05:01Z
dc.title.none.fl_str_mv Immune response and partial protection against heterologous foot-and-mouth disease virus induced by dendrimer peptides in cattle
title Immune response and partial protection against heterologous foot-and-mouth disease virus induced by dendrimer peptides in cattle
spellingShingle Immune response and partial protection against heterologous foot-and-mouth disease virus induced by dendrimer peptides in cattle
Soria, Ivana
Foot-and-mouth disease
Dendrimers
Peptides
title_short Immune response and partial protection against heterologous foot-and-mouth disease virus induced by dendrimer peptides in cattle
title_full Immune response and partial protection against heterologous foot-and-mouth disease virus induced by dendrimer peptides in cattle
title_fullStr Immune response and partial protection against heterologous foot-and-mouth disease virus induced by dendrimer peptides in cattle
title_full_unstemmed Immune response and partial protection against heterologous foot-and-mouth disease virus induced by dendrimer peptides in cattle
title_sort Immune response and partial protection against heterologous foot-and-mouth disease virus induced by dendrimer peptides in cattle
dc.creator.none.fl_str_mv Soria, Ivana
Quattrocchi, Valeria
Langellotti, Cecilia
Pérez-Filgueira, Mariano
Pega, J.
Gnazzo, V.
Romera, S.
Schammas, J.
Bucafusco, D.
Di Giacomo, S.
Torre, Beatriz G. de la
Andreu Martínez, David
Sobrino, Francisco
Blanco, Esther
Zamorano, Patricia
author Soria, Ivana
author_facet Soria, Ivana
Quattrocchi, Valeria
Langellotti, Cecilia
Pérez-Filgueira, Mariano
Pega, J.
Gnazzo, V.
Romera, S.
Schammas, J.
Bucafusco, D.
Di Giacomo, S.
Torre, Beatriz G. de la
Andreu Martínez, David
Sobrino, Francisco
Blanco, Esther
Zamorano, Patricia
author_role author
author2 Quattrocchi, Valeria
Langellotti, Cecilia
Pérez-Filgueira, Mariano
Pega, J.
Gnazzo, V.
Romera, S.
Schammas, J.
Bucafusco, D.
Di Giacomo, S.
Torre, Beatriz G. de la
Andreu Martínez, David
Sobrino, Francisco
Blanco, Esther
Zamorano, Patricia
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Foot-and-mouth disease
Dendrimers
Peptides
topic Foot-and-mouth disease
Dendrimers
Peptides
description Synthetic peptides mimicking protective B- and T-cell epitopes are good candidates for safer, more effective FMD vaccines. Nevertheless, previous studies of immunization with linear peptides showed that they failed to induce solid protection in cattle. Dendrimeric peptides displaying two or four copies of a peptide corresponding to the B-cell epitope VP1 [136-154] of type O FMDV (O/UKG/11/2001) linked through thioether bonds to a single copy of the T-cell epitope 3A [21-35] (termed B2T and B4T, resp.) afforded protection in vaccinated pigs. In this work, we show that dendrimeric peptides B2T and B4T can elicit specific humoral responses in cattle and confer partial protection against the challenge with a heterologous type O virus (O1/Campos/Bra/58). This protective response correlated with the induction of specific T-cells as well as with an anamnestic antibody response upon virus challenge, as shown by the detection of virus-specific antibody-secreting cells (ASC) in lymphoid tissues distal from the inoculation point
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/35676
http://dx.doi.org/10.1155/2018/3497401
url http://hdl.handle.net/10230/35676
http://dx.doi.org/10.1155/2018/3497401
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Immunology Research. 2018;2018:3497401
info:eu-repo/grantAgreement/ES/1PE/AGL2014-52395-C2
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi
publisher.none.fl_str_mv Hindawi
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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