Tumor cell dormancy

Metastasis is the primary cause of death in cancer patients and current treatments fail to provide durable responses. Efforts to treat metastatic disease are hindered by the fact that metastatic cells often remain dormant for prolonged intervals of years, or even decades. Tumor dormancy reflects the...

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Detalhes bibliográficos
Autores: Gomis i Cabré, Roger, Gawrzak, Sylwia
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/105636
Acesso em linha:https://hdl.handle.net/2445/105636
Access Level:acceso abierto
Palavra-chave:Cèl·lules canceroses
Tumors
Metàstasi
Cancer cells
Metastasis
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spelling Tumor cell dormancyGomis i Cabré, RogerGawrzak, SylwiaCèl·lules cancerosesTumorsMetàstasiCancer cellsTumorsMetastasisMetastasis is the primary cause of death in cancer patients and current treatments fail to provide durable responses. Efforts to treat metastatic disease are hindered by the fact that metastatic cells often remain dormant for prolonged intervals of years, or even decades. Tumor dormancy reflects the capability of disseminated tumor cells (DTCs), or micrometastases, to evade treatment and remain at low numbers after primary tumor resection. Unfortunately, dormant cells will eventually produce overt metastasis. Innovations are needed to understand metastatic dormancy and improve cancer detection and treatment. Currently, few models exist that faithfully recapitulate metastatic dormancy and metastasis to clinically relevant tissues, such as the bone. Herein, we discuss recent advances describing genetic cell-autonomous and systemic or local changes in the microenvironment that have been shown to endow DTCs with properties to survive and eventually colonize distant organs.Wiley2017201720162017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 p.application/pdfhttps://hdl.handle.net/2445/105636Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.1016/j.molonc.2016.09.009Molecular Oncology, 2016, vol 11, num. 1, p. 62-78http://dx.doi.org/10.1016/j.molonc.2016.09.009cc by nc-nd (c) Gomis; Gawrzak, 2016http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1056362026-05-29T05:05:01Z
dc.title.none.fl_str_mv Tumor cell dormancy
title Tumor cell dormancy
spellingShingle Tumor cell dormancy
Gomis i Cabré, Roger
Cèl·lules canceroses
Tumors
Metàstasi
Cancer cells
Tumors
Metastasis
title_short Tumor cell dormancy
title_full Tumor cell dormancy
title_fullStr Tumor cell dormancy
title_full_unstemmed Tumor cell dormancy
title_sort Tumor cell dormancy
dc.creator.none.fl_str_mv Gomis i Cabré, Roger
Gawrzak, Sylwia
author Gomis i Cabré, Roger
author_facet Gomis i Cabré, Roger
Gawrzak, Sylwia
author_role author
author2 Gawrzak, Sylwia
author2_role author
dc.subject.none.fl_str_mv Cèl·lules canceroses
Tumors
Metàstasi
Cancer cells
Tumors
Metastasis
topic Cèl·lules canceroses
Tumors
Metàstasi
Cancer cells
Tumors
Metastasis
description Metastasis is the primary cause of death in cancer patients and current treatments fail to provide durable responses. Efforts to treat metastatic disease are hindered by the fact that metastatic cells often remain dormant for prolonged intervals of years, or even decades. Tumor dormancy reflects the capability of disseminated tumor cells (DTCs), or micrometastases, to evade treatment and remain at low numbers after primary tumor resection. Unfortunately, dormant cells will eventually produce overt metastasis. Innovations are needed to understand metastatic dormancy and improve cancer detection and treatment. Currently, few models exist that faithfully recapitulate metastatic dormancy and metastasis to clinically relevant tissues, such as the bone. Herein, we discuss recent advances describing genetic cell-autonomous and systemic or local changes in the microenvironment that have been shown to endow DTCs with properties to survive and eventually colonize distant organs.
publishDate 2016
dc.date.none.fl_str_mv 2016
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/105636
url https://hdl.handle.net/2445/105636
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1016/j.molonc.2016.09.009
Molecular Oncology, 2016, vol 11, num. 1, p. 62-78
http://dx.doi.org/10.1016/j.molonc.2016.09.009
dc.rights.none.fl_str_mv cc by nc-nd (c) Gomis; Gawrzak, 2016
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by nc-nd (c) Gomis; Gawrzak, 2016
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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