Two-Generation Toxicity Study of the Antioxidant Compound Propyl-Propane Thiosulfonate (PTSO)

Propyl-propane thiosulfonate (PTSO), an antioxidant organosulfur compound present in the genus Allium, has become a potential natural additive for food and feed, as well as a possible biopesticide for pest control in plants. A toxicological assessment is necessary to verify its safety for livestock,...

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Autores: Cascajosa Lira, Antonio, Guzmán Guillén, Remedios, Pichardo Sánchez, Silvia, Baños, Alberto, de la Torre, José M., Ayala Soldado, N., Moyano Salvago, M. Rosario, Ortiz Jaraba, I., Cameán Fernández, Ana María, Jos Gallego, Ángeles Mencía
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/159971
Acceso en línea:https://hdl.handle.net/11441/159971
https://doi.org/10.3390/antiox13030350
Access Level:acceso abierto
Palabra clave:Alliumsp
Antioxidant
In vivo
Natural additive
Organosulfur compound
Safety assessment
Thiosulfonate
Two-generation toxicity
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spelling Two-Generation Toxicity Study of the Antioxidant Compound Propyl-Propane Thiosulfonate (PTSO)Cascajosa Lira, AntonioGuzmán Guillén, RemediosPichardo Sánchez, SilviaBaños, Albertode la Torre, José M.Ayala Soldado, N.Moyano Salvago, M. RosarioOrtiz Jaraba, I.Cameán Fernández, Ana MaríaJos Gallego, Ángeles MencíaAlliumspAntioxidantIn vivoNatural additiveOrganosulfur compoundSafety assessmentThiosulfonateTwo-generation toxicityPropyl-propane thiosulfonate (PTSO), an antioxidant organosulfur compound present in the genus Allium, has become a potential natural additive for food and feed, as well as a possible biopesticide for pest control in plants. A toxicological assessment is necessary to verify its safety for livestock, consumers, and the environment. As part of the risk assessment of PTSO, this study was designed to explore its potential reproductive toxicity in mice following the OECD 416 guideline. The investigation spans two generations to comprehensively evaluate potential reproductive, teratogenic, and hereditary effects. A total of 80 CD1 mice per sex and generation were subjected to PTSO exposure during three phases (premating, gestation, and lactation). This evaluation encompassed three dose levels: 14, 28, and 55 mg PTSO/kg b.w./day, administered through the feed. No clinical changes or mortality attributed to the administration of PTSO were observed in the study. Some changes in the body weight and food consumption were observed, but not related to sex or in a dose-dependent manner. The two parental generations (F0, F1) exhibited normal reproductive performance, and the offspring (F1 and F2) were born without any abnormalities. The serum sexual hormone levels (progesterone -P-, testosterone -T-, estradiol -E2-, follicular stimulating hormone -FSH-, and luteinizing hormone -LH-) were in a normal range. Although significant changes were observed in the sperm analysis in the case of F0 group, no variation was found for F1 group, and no alterations in fertility were recorded either. The absolute organ weights and relative organ weight/body weight and organ weight/brain weight ratios, and the complete histopathological study, showed no significant alterations in males and females for all the generations considered. Considering all the results obtained, PTSO is not considered a reproductive or developmental toxicant in mice under the assayed conditions. These results support the good safety profile of PTSO for its potential application in the agrifood sector.Junta de Andalucía P18-TP-2147Ministerio de Ciencia, Innovación y Universidades FPU2019-01247Universidad de Córdoba 26-06-2018-104Premio Mensual Publicación Científica Destacada de la US. Facultad de FarmaciaMultidisciplinary Digital Publishing Institute (MDPI)Nutrición y Bromatología, Toxicología y Medicina LegalJunta de AndalucíaMinisterio de Ciencia, Innovación y Universidades (MICINN). EspañaUniversidad de Córdoba2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/159971https://doi.org/10.3390/antiox13030350reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésAntioxidants, 13 (3), 350.P18-TP-2147FPU2019-0124726-06-2018-104https://doi.org/10.3390/antiox13030350info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1599712026-06-17T12:51:07Z
dc.title.none.fl_str_mv Two-Generation Toxicity Study of the Antioxidant Compound Propyl-Propane Thiosulfonate (PTSO)
title Two-Generation Toxicity Study of the Antioxidant Compound Propyl-Propane Thiosulfonate (PTSO)
spellingShingle Two-Generation Toxicity Study of the Antioxidant Compound Propyl-Propane Thiosulfonate (PTSO)
Cascajosa Lira, Antonio
Alliumsp
Antioxidant
In vivo
Natural additive
Organosulfur compound
Safety assessment
Thiosulfonate
Two-generation toxicity
title_short Two-Generation Toxicity Study of the Antioxidant Compound Propyl-Propane Thiosulfonate (PTSO)
title_full Two-Generation Toxicity Study of the Antioxidant Compound Propyl-Propane Thiosulfonate (PTSO)
title_fullStr Two-Generation Toxicity Study of the Antioxidant Compound Propyl-Propane Thiosulfonate (PTSO)
title_full_unstemmed Two-Generation Toxicity Study of the Antioxidant Compound Propyl-Propane Thiosulfonate (PTSO)
title_sort Two-Generation Toxicity Study of the Antioxidant Compound Propyl-Propane Thiosulfonate (PTSO)
dc.creator.none.fl_str_mv Cascajosa Lira, Antonio
Guzmán Guillén, Remedios
Pichardo Sánchez, Silvia
Baños, Alberto
de la Torre, José M.
Ayala Soldado, N.
Moyano Salvago, M. Rosario
Ortiz Jaraba, I.
Cameán Fernández, Ana María
Jos Gallego, Ángeles Mencía
author Cascajosa Lira, Antonio
author_facet Cascajosa Lira, Antonio
Guzmán Guillén, Remedios
Pichardo Sánchez, Silvia
Baños, Alberto
de la Torre, José M.
Ayala Soldado, N.
Moyano Salvago, M. Rosario
Ortiz Jaraba, I.
Cameán Fernández, Ana María
Jos Gallego, Ángeles Mencía
author_role author
author2 Guzmán Guillén, Remedios
Pichardo Sánchez, Silvia
Baños, Alberto
de la Torre, José M.
Ayala Soldado, N.
Moyano Salvago, M. Rosario
Ortiz Jaraba, I.
Cameán Fernández, Ana María
Jos Gallego, Ángeles Mencía
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Nutrición y Bromatología, Toxicología y Medicina Legal
Junta de Andalucía
Ministerio de Ciencia, Innovación y Universidades (MICINN). España
Universidad de Córdoba
dc.subject.none.fl_str_mv Alliumsp
Antioxidant
In vivo
Natural additive
Organosulfur compound
Safety assessment
Thiosulfonate
Two-generation toxicity
topic Alliumsp
Antioxidant
In vivo
Natural additive
Organosulfur compound
Safety assessment
Thiosulfonate
Two-generation toxicity
description Propyl-propane thiosulfonate (PTSO), an antioxidant organosulfur compound present in the genus Allium, has become a potential natural additive for food and feed, as well as a possible biopesticide for pest control in plants. A toxicological assessment is necessary to verify its safety for livestock, consumers, and the environment. As part of the risk assessment of PTSO, this study was designed to explore its potential reproductive toxicity in mice following the OECD 416 guideline. The investigation spans two generations to comprehensively evaluate potential reproductive, teratogenic, and hereditary effects. A total of 80 CD1 mice per sex and generation were subjected to PTSO exposure during three phases (premating, gestation, and lactation). This evaluation encompassed three dose levels: 14, 28, and 55 mg PTSO/kg b.w./day, administered through the feed. No clinical changes or mortality attributed to the administration of PTSO were observed in the study. Some changes in the body weight and food consumption were observed, but not related to sex or in a dose-dependent manner. The two parental generations (F0, F1) exhibited normal reproductive performance, and the offspring (F1 and F2) were born without any abnormalities. The serum sexual hormone levels (progesterone -P-, testosterone -T-, estradiol -E2-, follicular stimulating hormone -FSH-, and luteinizing hormone -LH-) were in a normal range. Although significant changes were observed in the sperm analysis in the case of F0 group, no variation was found for F1 group, and no alterations in fertility were recorded either. The absolute organ weights and relative organ weight/body weight and organ weight/brain weight ratios, and the complete histopathological study, showed no significant alterations in males and females for all the generations considered. Considering all the results obtained, PTSO is not considered a reproductive or developmental toxicant in mice under the assayed conditions. These results support the good safety profile of PTSO for its potential application in the agrifood sector.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/159971
https://doi.org/10.3390/antiox13030350
url https://hdl.handle.net/11441/159971
https://doi.org/10.3390/antiox13030350
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Antioxidants, 13 (3), 350.
P18-TP-2147
FPU2019-01247
26-06-2018-104
https://doi.org/10.3390/antiox13030350
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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