Photo-Organocatalytic Enantioselective Radical Cascade Reactions of Unactivated Olefins
Radical cascade processes are invaluable for their ability to rapidly construct complex chiral molecules from simple substrates. However, implementing catalytic asymmetric variants is difficult. Reported herein is a visible-light-mediated organocatalytic strategy that exploits the excited-state reac...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2072/350698 |
| Acceso en línea: | http://hdl.handle.net/2072/350698 https://doi.org/10.1002/anie.201808183 |
| Access Level: | acceso abierto |
| Palabra clave: | 54 |
| Sumario: | Radical cascade processes are invaluable for their ability to rapidly construct complex chiral molecules from simple substrates. However, implementing catalytic asymmetric variants is difficult. Reported herein is a visible-light-mediated organocatalytic strategy that exploits the excited-state reactivity of chiral iminium ions to trigger radical cascade reactions with high enantioselectivity. By combining two sequential radical- based bond-forming events, the method converts unactivated olefins and a,b-unsaturated aldehydes into chiral adducts in a single step. The implementation of an asymmetric three- component radical cascade further demonstrates the complex- ity-generating power of this photochemical strategy. |
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