Anxiety, depression, health-related quality of life, and mortality among colorectal patients: 5-year follow-up

Purpose Health-related quality of life (HRQoL) measurement represents an important outcome in cancer patients. We describe the evolution of HRQoL over a 5-year period in colorectal cancer patients, identifying predictors of change and how they relate to mortality. Methods Prospective observational c...

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Autores: Orive Calzada, Miren, Antón Ladislao, Ane, Lázaro Aramburu, Santiago, González, Nerea, Baré Mañas, Marisa, Fernández de Larrea, Nerea, Redondo, Maximino, Bilbao, Amaia, Sarasqueta Eizaguirre, Cristina, Aguirre, Urko, Quintana López, José María, REDISSEC-CARESS CCR Group
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/58155
Acceso en línea:http://hdl.handle.net/10810/58155
Access Level:acceso abierto
Palabra clave:colorectal cancer
patient-reported outcome measures
health-related quality of life
cohort studies
longitudinal studies
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network_name_str España
repository_id_str
dc.title.none.fl_str_mv Anxiety, depression, health-related quality of life, and mortality among colorectal patients: 5-year follow-up
title Anxiety, depression, health-related quality of life, and mortality among colorectal patients: 5-year follow-up
spellingShingle Anxiety, depression, health-related quality of life, and mortality among colorectal patients: 5-year follow-up
Orive Calzada, Miren
colorectal cancer
patient-reported outcome measures
health-related quality of life
cohort studies
longitudinal studies
title_short Anxiety, depression, health-related quality of life, and mortality among colorectal patients: 5-year follow-up
title_full Anxiety, depression, health-related quality of life, and mortality among colorectal patients: 5-year follow-up
title_fullStr Anxiety, depression, health-related quality of life, and mortality among colorectal patients: 5-year follow-up
title_full_unstemmed Anxiety, depression, health-related quality of life, and mortality among colorectal patients: 5-year follow-up
title_sort Anxiety, depression, health-related quality of life, and mortality among colorectal patients: 5-year follow-up
dc.creator.none.fl_str_mv Orive Calzada, Miren
Antón Ladislao, Ane
Lázaro Aramburu, Santiago
González, Nerea
Baré Mañas, Marisa
Fernández de Larrea, Nerea
Redondo, Maximino
Bilbao, Amaia
Sarasqueta Eizaguirre, Cristina
Aguirre, Urko
Quintana López, José María
REDISSEC-CARESS CCR Group
author Orive Calzada, Miren
author_facet Orive Calzada, Miren
Antón Ladislao, Ane
Lázaro Aramburu, Santiago
González, Nerea
Baré Mañas, Marisa
Fernández de Larrea, Nerea
Redondo, Maximino
Bilbao, Amaia
Sarasqueta Eizaguirre, Cristina
Aguirre, Urko
Quintana López, José María
REDISSEC-CARESS CCR Group
author_role author
author2 Antón Ladislao, Ane
Lázaro Aramburu, Santiago
González, Nerea
Baré Mañas, Marisa
Fernández de Larrea, Nerea
Redondo, Maximino
Bilbao, Amaia
Sarasqueta Eizaguirre, Cristina
Aguirre, Urko
Quintana López, José María
REDISSEC-CARESS CCR Group
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv colorectal cancer
patient-reported outcome measures
health-related quality of life
cohort studies
longitudinal studies
topic colorectal cancer
patient-reported outcome measures
health-related quality of life
cohort studies
longitudinal studies
description Purpose Health-related quality of life (HRQoL) measurement represents an important outcome in cancer patients. We describe the evolution of HRQoL over a 5-year period in colorectal cancer patients, identifying predictors of change and how they relate to mortality. Methods Prospective observational cohort study including colorectal cancer (CRC) patients having undergone surgery in nineteen public hospitals who were monitored from their diagnosis, intervention and at 1-, 2-, 3-, and 5-year periods thereafter by gathering HRQoL data using the EuroQol-5D-5L (EQ-5D-5L), European Organization for Research and Treatment of Cancer's Quality of Life Questionnaire-Core 30 (EORTC-QLQ-C30), and Hospital Anxiety and Depression Scale (HADS) questionnaires. Multivariable generalized linear mixed models were used. Results Predictors of Euroqol-5D-5L (EQ-5D-5L) changes were having worse baseline HRQoL; being female; higher Charlson index score (more comorbidities); complications during admission and 1 month after surgery; having a stoma after surgery; and needing or being in receipt of social support at baseline. For EORTC-QLQ-C30, predictors of changes were worse baseline EORTC-QLQ-C30 score; being female; higher Charlson score; complications during admission and 1 month after admission; receiving adjuvant chemotherapy; and having a family history of CRC. Predictors of changes in HADS anxiety were being female and having received adjuvant chemotherapy. Greater depression was associated with greater baseline depression; being female; higher Charlson score; having complications 1 month after intervention; and having a stoma. A deterioration in all HRQoL questionnaires in the previous year was related to death in the following year. Conclusions These findings should enable preventive follow-up programs to be established for such patients in order to reduce their psychological distress and improve their HRQoL to as great an extent as possible.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/58155
url http://hdl.handle.net/10810/58155
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://link.springer.com/article/10.1007/s00520-022-07177-1
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Anxiety, depression, health-related quality of life, and mortality among colorectal patients: 5-year follow-upOrive Calzada, MirenAntón Ladislao, AneLázaro Aramburu, SantiagoGonzález, NereaBaré Mañas, MarisaFernández de Larrea, NereaRedondo, MaximinoBilbao, AmaiaSarasqueta Eizaguirre, CristinaAguirre, UrkoQuintana López, José MaríaREDISSEC-CARESS CCR Groupcolorectal cancerpatient-reported outcome measureshealth-related quality of lifecohort studieslongitudinal studiesPurpose Health-related quality of life (HRQoL) measurement represents an important outcome in cancer patients. We describe the evolution of HRQoL over a 5-year period in colorectal cancer patients, identifying predictors of change and how they relate to mortality. Methods Prospective observational cohort study including colorectal cancer (CRC) patients having undergone surgery in nineteen public hospitals who were monitored from their diagnosis, intervention and at 1-, 2-, 3-, and 5-year periods thereafter by gathering HRQoL data using the EuroQol-5D-5L (EQ-5D-5L), European Organization for Research and Treatment of Cancer's Quality of Life Questionnaire-Core 30 (EORTC-QLQ-C30), and Hospital Anxiety and Depression Scale (HADS) questionnaires. Multivariable generalized linear mixed models were used. Results Predictors of Euroqol-5D-5L (EQ-5D-5L) changes were having worse baseline HRQoL; being female; higher Charlson index score (more comorbidities); complications during admission and 1 month after surgery; having a stoma after surgery; and needing or being in receipt of social support at baseline. For EORTC-QLQ-C30, predictors of changes were worse baseline EORTC-QLQ-C30 score; being female; higher Charlson score; complications during admission and 1 month after admission; receiving adjuvant chemotherapy; and having a family history of CRC. Predictors of changes in HADS anxiety were being female and having received adjuvant chemotherapy. Greater depression was associated with greater baseline depression; being female; higher Charlson score; having complications 1 month after intervention; and having a stoma. A deterioration in all HRQoL questionnaires in the previous year was related to death in the following year. Conclusions These findings should enable preventive follow-up programs to be established for such patients in order to reduce their psychological distress and improve their HRQoL to as great an extent as possible.Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This work was supported in part by grants from the Instituto de Salud Carlos III and the European Regional Development Fund (PS09/00314, PS09/00910, PS09/00746, PS09/00805, PI09/90460, PI09/90490, PI09/90453, PI09/90441, PI09/90397); the Departments of Health (2010111098) and Education, Language Policy and Culture (IT620-13) of the Basque Government; the Research Committee of Hospital Galdakao; and the thematic network-REDISSEC (Red de Investigacion en Servicios de Salud en Enfermedades Cronicas)-of the Instituto de Salud Carlos III.Springer202220222022info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/58155reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://link.springer.com/article/10.1007/s00520-022-07177-1info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/© The Author(s) 2022. This article is licensed under a Creative Commons Attri- bution 4.0 International License, which permits use, sharing, adapta- tion, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Atribución 3.0 Españaoai:addi.ehu.eus:10810/581552026-06-18T09:23:17Z
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