Host Antimicrobial Peptides
Tuberculosis (TB) continues to be a devastating infectious disease and remerges as a global health emergency due to an alarming rise of antimicrobial resistance to its treatment. Despite of the serious effort that has been applied to develop effective antitubercular chemotherapies, the potential of...
| Autores: | , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:254043 |
| Acceso en línea: | https://ddd.uab.cat/record/254043 https://dx.doi.org/urn:doi:10.3389/fimmu.2017.01499 |
| Access Level: | acceso abierto |
| Palabra clave: | Antimicrobial peptides Innate immunity Tuberculosis Infectious diseases Mycobacteria Antimicrobial resistance Host defense |
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Host Antimicrobial PeptidesThe Promise of New Treatment Strategies against TuberculosisArranz Trullén, Javier|||0000-0002-5559-9167Lu, Lu|||0000-0002-0960-1529Pulido-Gomez, David|||0000-0003-3422-0434Bhakta, Sanjib|||0000-0002-1165-9295Boix, Ester|||0000-0003-1790-2142Antimicrobial peptidesInnate immunityTuberculosisInfectious diseasesMycobacteriaAntimicrobial resistanceHost defenseTuberculosis (TB) continues to be a devastating infectious disease and remerges as a global health emergency due to an alarming rise of antimicrobial resistance to its treatment. Despite of the serious effort that has been applied to develop effective antitubercular chemotherapies, the potential of antimicrobial peptides (AMPs) remains underexploited. A large amount of literature is now accessible on the AMP mechanisms of action against a diversity of pathogens; nevertheless, research on their activity on mycobacteria is still scarce. In particular, there is an urgent need to integrate all available interdisciplinary strategies to eradicate extensively drug-resistant Mycobacterium tuberculosis strains. In this context, we should not underestimate our endogenous antimicrobial proteins and peptides as ancient players of the human host defense system. We are confident that novel antibiotics based on human AMPs displaying a rapid and multifaceted mechanism, with reduced toxicity, should significantly contribute to reverse the tide of antimycobacterial drug resistance. In this review, we have provided an up to date perspective of the current research on AMPs to be applied in the fight against TB. A better understanding on the mechanisms of action of human endogenous peptides should ensure the basis for the best guided design of novel antitubercular chemotherapeutics. 22017-01-0120172017-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/254043https://dx.doi.org/urn:doi:10.3389/fimmu.2017.01499reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 SAF2015-66007Popen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2540432026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Host Antimicrobial Peptides The Promise of New Treatment Strategies against Tuberculosis |
| title |
Host Antimicrobial Peptides |
| spellingShingle |
Host Antimicrobial Peptides Arranz Trullén, Javier|||0000-0002-5559-9167 Antimicrobial peptides Innate immunity Tuberculosis Infectious diseases Mycobacteria Antimicrobial resistance Host defense |
| title_short |
Host Antimicrobial Peptides |
| title_full |
Host Antimicrobial Peptides |
| title_fullStr |
Host Antimicrobial Peptides |
| title_full_unstemmed |
Host Antimicrobial Peptides |
| title_sort |
Host Antimicrobial Peptides |
| dc.creator.none.fl_str_mv |
Arranz Trullén, Javier|||0000-0002-5559-9167 Lu, Lu|||0000-0002-0960-1529 Pulido-Gomez, David|||0000-0003-3422-0434 Bhakta, Sanjib|||0000-0002-1165-9295 Boix, Ester|||0000-0003-1790-2142 |
| author |
Arranz Trullén, Javier|||0000-0002-5559-9167 |
| author_facet |
Arranz Trullén, Javier|||0000-0002-5559-9167 Lu, Lu|||0000-0002-0960-1529 Pulido-Gomez, David|||0000-0003-3422-0434 Bhakta, Sanjib|||0000-0002-1165-9295 Boix, Ester|||0000-0003-1790-2142 |
| author_role |
author |
| author2 |
Lu, Lu|||0000-0002-0960-1529 Pulido-Gomez, David|||0000-0003-3422-0434 Bhakta, Sanjib|||0000-0002-1165-9295 Boix, Ester|||0000-0003-1790-2142 |
| author2_role |
author author author author |
| dc.subject.none.fl_str_mv |
Antimicrobial peptides Innate immunity Tuberculosis Infectious diseases Mycobacteria Antimicrobial resistance Host defense |
| topic |
Antimicrobial peptides Innate immunity Tuberculosis Infectious diseases Mycobacteria Antimicrobial resistance Host defense |
| description |
Tuberculosis (TB) continues to be a devastating infectious disease and remerges as a global health emergency due to an alarming rise of antimicrobial resistance to its treatment. Despite of the serious effort that has been applied to develop effective antitubercular chemotherapies, the potential of antimicrobial peptides (AMPs) remains underexploited. A large amount of literature is now accessible on the AMP mechanisms of action against a diversity of pathogens; nevertheless, research on their activity on mycobacteria is still scarce. In particular, there is an urgent need to integrate all available interdisciplinary strategies to eradicate extensively drug-resistant Mycobacterium tuberculosis strains. In this context, we should not underestimate our endogenous antimicrobial proteins and peptides as ancient players of the human host defense system. We are confident that novel antibiotics based on human AMPs displaying a rapid and multifaceted mechanism, with reduced toxicity, should significantly contribute to reverse the tide of antimycobacterial drug resistance. In this review, we have provided an up to date perspective of the current research on AMPs to be applied in the fight against TB. A better understanding on the mechanisms of action of human endogenous peptides should ensure the basis for the best guided design of novel antitubercular chemotherapeutics. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2 2017-01-01 2017 2017-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/254043 https://dx.doi.org/urn:doi:10.3389/fimmu.2017.01499 |
| url |
https://ddd.uab.cat/record/254043 https://dx.doi.org/urn:doi:10.3389/fimmu.2017.01499 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
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Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 SAF2015-66007P |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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Dipòsit Digital de Documents de la UAB |
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