Enhancing Survival, Engraftment, and Osteogenic Potential of Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are promising candidates for bone regeneration therapies due to their plasticity and easiness of sourcing. MSC-based treatments are generally considered a safe procedure, however, the long-term results obtained up to now are far from satisfactory. The main causes of the...

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Autores: Garcia-Sanchez, Daniel, Fernandez, Dario, Rodríguez Rey, José Carlos|||0000-0002-8369-3118, Pérez Campo, Flor María|||0000-0002-9872-7990
Formato: artículo
Fecha de publicación:2019
País:España
Recursos:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/17882
Acesso em linha:http://hdl.handle.net/10902/17882
Access Level:acceso abierto
Palavra-chave:Mesenchymal Stem Cells
Bone Regeneration
Hypoxia
Anoikis
Preconditioning
Bioactive Scaffolds
Senescence
Engraftment
Homing
Osteogenesis
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spelling Enhancing Survival, Engraftment, and Osteogenic Potential of Mesenchymal Stem CellsGarcia-Sanchez, DanielFernandez, DarioRodríguez Rey, José Carlos|||0000-0002-8369-3118 Pérez Campo, Flor María|||0000-0002-9872-7990Mesenchymal Stem CellsBone RegenerationHypoxiaAnoikisPreconditioningBioactive ScaffoldsSenescenceEngraftmentHomingOsteogenesisMesenchymal stem cells (MSCs) are promising candidates for bone regeneration therapies due to their plasticity and easiness of sourcing. MSC-based treatments are generally considered a safe procedure, however, the long-term results obtained up to now are far from satisfactory. The main causes of these therapeutic limitations are inefficient homing, engraftment, and osteogenic differentiation. Many studies have proposed modifications to improve MSC engraftment and osteogenic differentiation of the transplanted cells. Several strategies are aimed to improve cell resistance to the hostile microenvironment found in the recipient tissue and increase cell survival after transplantation. These strategies could range from a simple modification of the culture conditions, known as cell-preconditioning, to the genetic modification of the cells to avoid cellular senescence. Many efforts have also been done in order to enhance the osteogenic potential of the transplanted cells and induce bone formation, mainly by the use of bioactive or biomimetic scaffolds, although alternative approaches will also be discussed. This review aims to summarize several of the most recent approaches, providing an up-to-date view of the main developments in MSC-based regenerative techniques.Baishideng Publishing GroupUniversidad de Cantabria20192019-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10902/17882World J Stem Cells , 11 (10), 748-763reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/178822026-06-02T12:39:31Z
dc.title.none.fl_str_mv Enhancing Survival, Engraftment, and Osteogenic Potential of Mesenchymal Stem Cells
title Enhancing Survival, Engraftment, and Osteogenic Potential of Mesenchymal Stem Cells
spellingShingle Enhancing Survival, Engraftment, and Osteogenic Potential of Mesenchymal Stem Cells
Garcia-Sanchez, Daniel
Mesenchymal Stem Cells
Bone Regeneration
Hypoxia
Anoikis
Preconditioning
Bioactive Scaffolds
Senescence
Engraftment
Homing
Osteogenesis
title_short Enhancing Survival, Engraftment, and Osteogenic Potential of Mesenchymal Stem Cells
title_full Enhancing Survival, Engraftment, and Osteogenic Potential of Mesenchymal Stem Cells
title_fullStr Enhancing Survival, Engraftment, and Osteogenic Potential of Mesenchymal Stem Cells
title_full_unstemmed Enhancing Survival, Engraftment, and Osteogenic Potential of Mesenchymal Stem Cells
title_sort Enhancing Survival, Engraftment, and Osteogenic Potential of Mesenchymal Stem Cells
dc.creator.none.fl_str_mv Garcia-Sanchez, Daniel
Fernandez, Dario
Rodríguez Rey, José Carlos|||0000-0002-8369-3118
Pérez Campo, Flor María|||0000-0002-9872-7990
author Garcia-Sanchez, Daniel
author_facet Garcia-Sanchez, Daniel
Fernandez, Dario
Rodríguez Rey, José Carlos|||0000-0002-8369-3118
Pérez Campo, Flor María|||0000-0002-9872-7990
author_role author
author2 Fernandez, Dario
Rodríguez Rey, José Carlos|||0000-0002-8369-3118
Pérez Campo, Flor María|||0000-0002-9872-7990
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Mesenchymal Stem Cells
Bone Regeneration
Hypoxia
Anoikis
Preconditioning
Bioactive Scaffolds
Senescence
Engraftment
Homing
Osteogenesis
topic Mesenchymal Stem Cells
Bone Regeneration
Hypoxia
Anoikis
Preconditioning
Bioactive Scaffolds
Senescence
Engraftment
Homing
Osteogenesis
description Mesenchymal stem cells (MSCs) are promising candidates for bone regeneration therapies due to their plasticity and easiness of sourcing. MSC-based treatments are generally considered a safe procedure, however, the long-term results obtained up to now are far from satisfactory. The main causes of these therapeutic limitations are inefficient homing, engraftment, and osteogenic differentiation. Many studies have proposed modifications to improve MSC engraftment and osteogenic differentiation of the transplanted cells. Several strategies are aimed to improve cell resistance to the hostile microenvironment found in the recipient tissue and increase cell survival after transplantation. These strategies could range from a simple modification of the culture conditions, known as cell-preconditioning, to the genetic modification of the cells to avoid cellular senescence. Many efforts have also been done in order to enhance the osteogenic potential of the transplanted cells and induce bone formation, mainly by the use of bioactive or biomimetic scaffolds, although alternative approaches will also be discussed. This review aims to summarize several of the most recent approaches, providing an up-to-date view of the main developments in MSC-based regenerative techniques.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10902/17882
url http://hdl.handle.net/10902/17882
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Baishideng Publishing Group
publisher.none.fl_str_mv Baishideng Publishing Group
dc.source.none.fl_str_mv World J Stem Cells , 11 (10), 748-763
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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