The integrated genomic surveillance system of Andalusia (SIEGA) provides a One Health regional resource connected with the clinic
The One Health approach, recognizing the interconnectedness of human, animal, and environmental health, has gained significance amid emerging zoonotic diseases and antibiotic resistance concerns. This paper aims to demonstrate the utility of a collaborative tool, the SIEGA, for monitoring infectious...
| Autores: | , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/368074 |
| Acceso en línea: | http://hdl.handle.net/10261/368074 https://api.elsevier.com/content/abstract/scopus_id/85201562595 |
| Access Level: | acceso abierto |
| Palabra clave: | AMR Epidemiology One health Resistances Surveillance Whole genome sequencing |
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| dc.title.none.fl_str_mv |
The integrated genomic surveillance system of Andalusia (SIEGA) provides a One Health regional resource connected with the clinic |
| title |
The integrated genomic surveillance system of Andalusia (SIEGA) provides a One Health regional resource connected with the clinic |
| spellingShingle |
The integrated genomic surveillance system of Andalusia (SIEGA) provides a One Health regional resource connected with the clinic Casimiro-Soriguer, Carlos S. AMR Epidemiology One health Resistances Surveillance Whole genome sequencing |
| title_short |
The integrated genomic surveillance system of Andalusia (SIEGA) provides a One Health regional resource connected with the clinic |
| title_full |
The integrated genomic surveillance system of Andalusia (SIEGA) provides a One Health regional resource connected with the clinic |
| title_fullStr |
The integrated genomic surveillance system of Andalusia (SIEGA) provides a One Health regional resource connected with the clinic |
| title_full_unstemmed |
The integrated genomic surveillance system of Andalusia (SIEGA) provides a One Health regional resource connected with the clinic |
| title_sort |
The integrated genomic surveillance system of Andalusia (SIEGA) provides a One Health regional resource connected with the clinic |
| dc.creator.none.fl_str_mv |
Casimiro-Soriguer, Carlos S. Pérez-Florido, Javier Robles, Enrique A. Lara, María Aguado, Andrea Rodríguez Iglesias, Manuel A. Lepe, José A. García, Federico Pérez-Alegre, Mónica Andújar, Eloísa Jiménez, Victoria E. Camino, Lola P. Loruso, Nicola Ameyugo, Ulises Vazquez, Isabel María Lozano, Carlota M. Chaves, J. Alberto Dopazo, Joaquín |
| author |
Casimiro-Soriguer, Carlos S. |
| author_facet |
Casimiro-Soriguer, Carlos S. Pérez-Florido, Javier Robles, Enrique A. Lara, María Aguado, Andrea Rodríguez Iglesias, Manuel A. Lepe, José A. García, Federico Pérez-Alegre, Mónica Andújar, Eloísa Jiménez, Victoria E. Camino, Lola P. Loruso, Nicola Ameyugo, Ulises Vazquez, Isabel María Lozano, Carlota M. Chaves, J. Alberto Dopazo, Joaquín |
| author_role |
author |
| author2 |
Pérez-Florido, Javier Robles, Enrique A. Lara, María Aguado, Andrea Rodríguez Iglesias, Manuel A. Lepe, José A. García, Federico Pérez-Alegre, Mónica Andújar, Eloísa Jiménez, Victoria E. Camino, Lola P. Loruso, Nicola Ameyugo, Ulises Vazquez, Isabel María Lozano, Carlota M. Chaves, J. Alberto Dopazo, Joaquín |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Salud Carlos III Junta de Andalucía European Commission Agencia Estatal de Investigación (España) Ministerio de Ciencia e Innovación (España) Andújar, Eloísa [0000-0002-8434-5078] Pérez-Alegre, Mónica [0000-0002-6060-6990] Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
AMR Epidemiology One health Resistances Surveillance Whole genome sequencing |
| topic |
AMR Epidemiology One health Resistances Surveillance Whole genome sequencing |
| description |
The One Health approach, recognizing the interconnectedness of human, animal, and environmental health, has gained significance amid emerging zoonotic diseases and antibiotic resistance concerns. This paper aims to demonstrate the utility of a collaborative tool, the SIEGA, for monitoring infectious diseases across domains, fostering a comprehensive understanding of disease dynamics and risk factors, highlighting the pivotal role of One Health surveillance systems. Raw whole-genome sequencing is processed through different species-specific open software that additionally reports the presence of genes associated to anti-microbial resistances and virulence. The SIEGA application is a Laboratory Information Management System, that allows customizing reports, detect transmission chains, and promptly alert on alarming genetic similarities. The SIEGA initiative has successfully accumulated a comprehensive collection of more than 1900 bacterial genomes, including Salmonella enterica, Listeria monocytogenes, Campylobacter jejuni, Escherichia coli, Yersinia enterocolitica and Legionella pneumophila, showcasing its potential in monitoring pathogen transmission, resistance patterns, and virulence factors. SIEGA enables customizable reports and prompt detection of transmission chains, highlighting its contribution to enhancing vigilance and response capabilities. Here we show the potential of genomics in One Health surveillance when supported by an appropriate bioinformatic tool. By facilitating precise disease control strategies and antimicrobial resistance management, SIEGA enhances global health security and reduces the burden of infectious diseases. The integration of health data from humans, animals, and the environment, coupled with advanced genomics, underscores the importance of a holistic One Health approach in mitigating health threats. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2024 2024 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10261/368074 https://api.elsevier.com/content/abstract/scopus_id/85201562595 |
| url |
http://hdl.handle.net/10261/368074 https://api.elsevier.com/content/abstract/scopus_id/85201562595 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
#PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI//FJC2021-046546-I Casimiro-Soriguer, Carlos S.; Pérez-Florido, Javier; Robles, Enrique A.; Lara, María; Aguado, Andrea; Rodríguez Iglesias, Manuel A.; Lepe, José A.; García, Federico; Pérez-Alegre, Mónica; Andújar, Eloísa; Jiménez, Victoria E.; Camino, Lola P.; Loruso, Nicola; Ameyugo, Ulises; Vázquez, Isabel María; Lozano, Carlota M.; Chaves, J. Alberto; Dopazo, Joaquin; 2024; Supplementary Results The integrated genomic surveillance system of Andalusia (SIEGA) provides a One Health regional resource connected with the clinic [Dataset]; Nature Publishing Group; https://doi.org/10.1038/s41598-024-70107-0 https://doi.org/10.1038/s41598-024-70107-0 Sí |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Nature Publishing Group |
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Nature Publishing Group |
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reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC) |
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Consejo Superior de Investigaciones Científicas (CSIC) |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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1869424458056335360 |
| spelling |
The integrated genomic surveillance system of Andalusia (SIEGA) provides a One Health regional resource connected with the clinicCasimiro-Soriguer, Carlos S.Pérez-Florido, JavierRobles, Enrique A.Lara, MaríaAguado, AndreaRodríguez Iglesias, Manuel A.Lepe, José A.García, FedericoPérez-Alegre, MónicaAndújar, EloísaJiménez, Victoria E.Camino, Lola P.Loruso, NicolaAmeyugo, UlisesVazquez, Isabel MaríaLozano, Carlota M.Chaves, J. AlbertoDopazo, JoaquínAMREpidemiologyOne healthResistancesSurveillanceWhole genome sequencingThe One Health approach, recognizing the interconnectedness of human, animal, and environmental health, has gained significance amid emerging zoonotic diseases and antibiotic resistance concerns. This paper aims to demonstrate the utility of a collaborative tool, the SIEGA, for monitoring infectious diseases across domains, fostering a comprehensive understanding of disease dynamics and risk factors, highlighting the pivotal role of One Health surveillance systems. Raw whole-genome sequencing is processed through different species-specific open software that additionally reports the presence of genes associated to anti-microbial resistances and virulence. The SIEGA application is a Laboratory Information Management System, that allows customizing reports, detect transmission chains, and promptly alert on alarming genetic similarities. The SIEGA initiative has successfully accumulated a comprehensive collection of more than 1900 bacterial genomes, including Salmonella enterica, Listeria monocytogenes, Campylobacter jejuni, Escherichia coli, Yersinia enterocolitica and Legionella pneumophila, showcasing its potential in monitoring pathogen transmission, resistance patterns, and virulence factors. SIEGA enables customizable reports and prompt detection of transmission chains, highlighting its contribution to enhancing vigilance and response capabilities. Here we show the potential of genomics in One Health surveillance when supported by an appropriate bioinformatic tool. By facilitating precise disease control strategies and antimicrobial resistance management, SIEGA enhances global health security and reduces the burden of infectious diseases. The integration of health data from humans, animals, and the environment, coupled with advanced genomics, underscores the importance of a holistic One Health approach in mitigating health threats.This work was supported by the Instituto de Salud Carlos III (ISCIII), co-funded with European Regional Development Funds (ERDF) (Grant IMP/00019), it has also been funded by Consejería de Salud y Consumo, Junta de Andalucía (Grants COVID-0012-2020, PIP-0087-2021), and by grant ELIXIR-CONVERGE—Connect and align ELIXIR Nodes to deliver sustainable FAIR lifescience data management services (AMD-871075-16), funded by EU – H2020. CSCS was funded by a Juan de la Cierva Grant (FJC2021-046546-I) from Ministerio de Ciencia e Innovación.Peer reviewedNature Publishing GroupInstituto de Salud Carlos IIIJunta de AndalucíaEuropean CommissionAgencia Estatal de Investigación (España)Ministerio de Ciencia e Innovación (España)Andújar, Eloísa [0000-0002-8434-5078]Pérez-Alegre, Mónica [0000-0002-6060-6990]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/368074https://api.elsevier.com/content/abstract/scopus_id/85201562595reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI//FJC2021-046546-ICasimiro-Soriguer, Carlos S.; Pérez-Florido, Javier; Robles, Enrique A.; Lara, María; Aguado, Andrea; Rodríguez Iglesias, Manuel A.; Lepe, José A.; García, Federico; Pérez-Alegre, Mónica; Andújar, Eloísa; Jiménez, Victoria E.; Camino, Lola P.; Loruso, Nicola; Ameyugo, Ulises; Vázquez, Isabel María; Lozano, Carlota M.; Chaves, J. Alberto; Dopazo, Joaquin; 2024; Supplementary Results The integrated genomic surveillance system of Andalusia (SIEGA) provides a One Health regional resource connected with the clinic [Dataset]; Nature Publishing Group; https://doi.org/10.1038/s41598-024-70107-0https://doi.org/10.1038/s41598-024-70107-0Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3680742026-05-22T06:33:51Z |
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15,812429 |