The AMPA receptor modulator S18986 in the prelimbic cortex enhances acquisition and retention of an odor-reward association

Systemic administration of S18986, a positive allosteric modulator of AMPA receptors, improves cognition. The present study further characterizes the drug's memory-enhancing properties and is the first to investigate its intracerebral effects on learning and memory. The results showed that rats...

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Autores: Yefimenko, Natalya, Portero Tresserra, Marta|||0000-0003-4149-1339, Martí Nicolovius, Margarita|||0000-0002-8669-6285, Guillazo i Blanch, Gemma|||0000-0002-8297-7100, Vale Martínez, Anna|||0000-0001-7369-7134
Formato: artículo
Fecha de publicación:2013
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:186506
Acesso em linha:https://ddd.uab.cat/record/186506
https://dx.doi.org/urn:doi:10.1016/j.neulet.2013.05.032
Access Level:acceso abierto
Palavra-chave:AMPA receptors
Cognitive enhancer
Glutamate
Memory facilitation
Olfactory discrimination
Prefrontal cortex
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spelling The AMPA receptor modulator S18986 in the prelimbic cortex enhances acquisition and retention of an odor-reward associationYefimenko, NatalyaPortero Tresserra, Marta|||0000-0003-4149-1339Martí Nicolovius, Margarita|||0000-0002-8669-6285Guillazo i Blanch, Gemma|||0000-0002-8297-7100Vale Martínez, Anna|||0000-0001-7369-7134AMPA receptorsCognitive enhancerGlutamateMemory facilitationOlfactory discriminationPrefrontal cortexSystemic administration of S18986, a positive allosteric modulator of AMPA receptors, improves cognition. The present study further characterizes the drug's memory-enhancing properties and is the first to investigate its intracerebral effects on learning and memory. The results showed that rats receiving a single dose of S18986 (3 μg/site) into the prelimbic cortex, prior to olfactory discrimination acquisition, exhibited significantly shorter latencies and fewer errors to make the correct response, both in the acquisition and two drug-free retention tests. Such findings corroborate the involvement of glutamate receptors in odor-reward learning and confirm the role of the AMPAkine S18986 as a cognitive enhancer. 22013-01-0120132013-01-01Articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/186506https://dx.doi.org/urn:doi:10.1016/j.neulet.2013.05.032reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.https://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1865062026-06-06T12:50:31Z
dc.title.none.fl_str_mv The AMPA receptor modulator S18986 in the prelimbic cortex enhances acquisition and retention of an odor-reward association
title The AMPA receptor modulator S18986 in the prelimbic cortex enhances acquisition and retention of an odor-reward association
spellingShingle The AMPA receptor modulator S18986 in the prelimbic cortex enhances acquisition and retention of an odor-reward association
Yefimenko, Natalya
AMPA receptors
Cognitive enhancer
Glutamate
Memory facilitation
Olfactory discrimination
Prefrontal cortex
title_short The AMPA receptor modulator S18986 in the prelimbic cortex enhances acquisition and retention of an odor-reward association
title_full The AMPA receptor modulator S18986 in the prelimbic cortex enhances acquisition and retention of an odor-reward association
title_fullStr The AMPA receptor modulator S18986 in the prelimbic cortex enhances acquisition and retention of an odor-reward association
title_full_unstemmed The AMPA receptor modulator S18986 in the prelimbic cortex enhances acquisition and retention of an odor-reward association
title_sort The AMPA receptor modulator S18986 in the prelimbic cortex enhances acquisition and retention of an odor-reward association
dc.creator.none.fl_str_mv Yefimenko, Natalya
Portero Tresserra, Marta|||0000-0003-4149-1339
Martí Nicolovius, Margarita|||0000-0002-8669-6285
Guillazo i Blanch, Gemma|||0000-0002-8297-7100
Vale Martínez, Anna|||0000-0001-7369-7134
author Yefimenko, Natalya
author_facet Yefimenko, Natalya
Portero Tresserra, Marta|||0000-0003-4149-1339
Martí Nicolovius, Margarita|||0000-0002-8669-6285
Guillazo i Blanch, Gemma|||0000-0002-8297-7100
Vale Martínez, Anna|||0000-0001-7369-7134
author_role author
author2 Portero Tresserra, Marta|||0000-0003-4149-1339
Martí Nicolovius, Margarita|||0000-0002-8669-6285
Guillazo i Blanch, Gemma|||0000-0002-8297-7100
Vale Martínez, Anna|||0000-0001-7369-7134
author2_role author
author
author
author
dc.subject.none.fl_str_mv AMPA receptors
Cognitive enhancer
Glutamate
Memory facilitation
Olfactory discrimination
Prefrontal cortex
topic AMPA receptors
Cognitive enhancer
Glutamate
Memory facilitation
Olfactory discrimination
Prefrontal cortex
description Systemic administration of S18986, a positive allosteric modulator of AMPA receptors, improves cognition. The present study further characterizes the drug's memory-enhancing properties and is the first to investigate its intracerebral effects on learning and memory. The results showed that rats receiving a single dose of S18986 (3 μg/site) into the prelimbic cortex, prior to olfactory discrimination acquisition, exhibited significantly shorter latencies and fewer errors to make the correct response, both in the acquisition and two drug-free retention tests. Such findings corroborate the involvement of glutamate receptors in odor-reward learning and confirm the role of the AMPAkine S18986 as a cognitive enhancer.
publishDate 2013
dc.date.none.fl_str_mv 2
2013-01-01
2013
2013-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/186506
https://dx.doi.org/urn:doi:10.1016/j.neulet.2013.05.032
url https://ddd.uab.cat/record/186506
https://dx.doi.org/urn:doi:10.1016/j.neulet.2013.05.032
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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