Electrocardiographic imaging including intracardiac information to achieve accurate global mapping during atrial fibrillation

[EN] Atrial fibrillation (AF) is characterized by complex and irregular propagation patterns. Noninvasive electrocardiographic imaging (ECGI) has been tested during AF conditions with promising results. However, current regularization methods face important challenges in this type of unstable electr...

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Autores: Cámara-Vázquez, Miguel Ángel, Hernández-Romero, Ismael, Rodrigo, Miguel, Alonso-Atienza, Felipe, Figuera, Carlos, Morgado-Reyes, Eduardo, Atienza, Felipe, Barquero-Pérez, Óscar, Guillem Sánchez, María Salud|||0000-0001-5660-3693, Andreu M. Climent|||0000-0002-7260-8811
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/183497
Acceso en línea:https://riunet.upv.es/handle/10251/183497
Access Level:acceso abierto
Palabra clave:Atrial fibrillation
ECG imaging
Inverse problem
Epicardial potentials
Dominant frequency
Rotor location
TECNOLOGIA ELECTRONICA
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dc.title.none.fl_str_mv Electrocardiographic imaging including intracardiac information to achieve accurate global mapping during atrial fibrillation
title Electrocardiographic imaging including intracardiac information to achieve accurate global mapping during atrial fibrillation
spellingShingle Electrocardiographic imaging including intracardiac information to achieve accurate global mapping during atrial fibrillation
Cámara-Vázquez, Miguel Ángel
Atrial fibrillation
ECG imaging
Inverse problem
Epicardial potentials
Dominant frequency
Rotor location
TECNOLOGIA ELECTRONICA
title_short Electrocardiographic imaging including intracardiac information to achieve accurate global mapping during atrial fibrillation
title_full Electrocardiographic imaging including intracardiac information to achieve accurate global mapping during atrial fibrillation
title_fullStr Electrocardiographic imaging including intracardiac information to achieve accurate global mapping during atrial fibrillation
title_full_unstemmed Electrocardiographic imaging including intracardiac information to achieve accurate global mapping during atrial fibrillation
title_sort Electrocardiographic imaging including intracardiac information to achieve accurate global mapping during atrial fibrillation
dc.creator.none.fl_str_mv Cámara-Vázquez, Miguel Ángel
Hernández-Romero, Ismael
Rodrigo, Miguel
Alonso-Atienza, Felipe
Figuera, Carlos
Morgado-Reyes, Eduardo
Atienza, Felipe
Barquero-Pérez, Óscar
Guillem Sánchez, María Salud|||0000-0001-5660-3693
Andreu M. Climent|||0000-0002-7260-8811
author Cámara-Vázquez, Miguel Ángel
author_facet Cámara-Vázquez, Miguel Ángel
Hernández-Romero, Ismael
Rodrigo, Miguel
Alonso-Atienza, Felipe
Figuera, Carlos
Morgado-Reyes, Eduardo
Atienza, Felipe
Barquero-Pérez, Óscar
Guillem Sánchez, María Salud|||0000-0001-5660-3693
Andreu M. Climent|||0000-0002-7260-8811
author_role author
author2 Hernández-Romero, Ismael
Rodrigo, Miguel
Alonso-Atienza, Felipe
Figuera, Carlos
Morgado-Reyes, Eduardo
Atienza, Felipe
Barquero-Pérez, Óscar
Guillem Sánchez, María Salud|||0000-0001-5660-3693
Andreu M. Climent|||0000-0002-7260-8811
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Ingeniería Electrónica
Escuela Técnica Superior de Ingeniería de Telecomunicación
Instituto Universitario de Tecnologías de la Información y Comunicaciones
Generalitat Valenciana
Instituto de Salud Carlos III
Agencia Estatal de Investigación
European Regional Development Fund
Ministerio de Economía y Competitividad
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Atrial fibrillation
ECG imaging
Inverse problem
Epicardial potentials
Dominant frequency
Rotor location
TECNOLOGIA ELECTRONICA
topic Atrial fibrillation
ECG imaging
Inverse problem
Epicardial potentials
Dominant frequency
Rotor location
TECNOLOGIA ELECTRONICA
description [EN] Atrial fibrillation (AF) is characterized by complex and irregular propagation patterns. Noninvasive electrocardiographic imaging (ECGI) has been tested during AF conditions with promising results. However, current regularization methods face important challenges in this type of unstable electrical activity scenarios. Combination of intracardiac and non-invasive simultaneous recordings could improve ECGI performance and allow real-time global mapping of complex AF patterns. In this work, we propose an ECGI method that incorporates intracardiac measurements as a constraint in a reformulation of the classical Tikhonov method. We used realistic mathematical models of atria and torso that simulates a wide number of epicardial electrical activity patterns. Body surface potentials were obtained from simulated electrograms (EGMs) by using Boundary Element Method and corrupted with Gaussian noise. Epicardial potentials were estimated using inverse problem with Tikhonov regularization, including intracavitary information as a second constraint. Results showed that first-order Constrained Tikhonov formulation provided more reliable reconstructions than the classical Tikhonov approach in AF conditions using at least 32 uniformly distributed endocardial EGMs (CC between 0.87 and 0.28, depending on the AF complexity). Constrained Tikhonov provided more accurate spatial mass functions (SMF) of PS locations (CC smF between 0.24 and 0.86). This methodology was tested on real patient data, obtaining a mean DF RMSE of 0.85 Hz, outperforming the classical Tikhonov approach. Limitations of this study include the fact that the model considered endocardium and epicardium as a single layer. Further research will include endocardium-epicardium bilayer model approximations and validation using more real patient data.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-02-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
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dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/183497
url https://riunet.upv.es/handle/10251/183497
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2019-105032GB-I00 PROCESAMIENTO DE SEÑAL PARA DATOS DEFINIDOS SOBRE GRAFOS: APROVECHANDO LA ESTRUCTURA EN DOMINIOS IRREGULARES
Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 TEC2016-75361-R
Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 DTS16%2F00160 Guiado en Tiempo Real de la Ablación de la Fibrilación Auricular mediante Cartografía Eléctrica Global (CORIFY)
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17%2F01059
Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 IJCI-2014-22178 IJCI-2014-22178
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17%2F01106
Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 PI16%2F01123 Regeneración Cardiaca de Infarto Crónico Porcino mediante Inyecciónes Intramiocardiacas de Células Progenitoras Embebidas en Hidrogeles de Matriz Decelularizada
Generalitat Valenciana https://doi.org/10.13039/501100003359 APOSTD%2F2017%2F068 Estratificación multiparamétrica de pacientes con fibrilación auricular
Generalitat Valenciana https://doi.org/10.13039/501100003359 GV%2F2018%2F103 MODELOS IN-SILICO PARA LA PERSONALIZACION DE TERAPIAS EN FIBRILACION AURICULAR
Generalitat Valenciana https://doi.org/10.13039/501100003359 AICO%2F2018%2F267 TECNOLOGIAS DE IMAGEN ELECTROCARDIOGRAFICA PARA LA PERSONALIZACION DE LOS TRATAMIENTOS PARA FIBRILACION AURICULAR
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
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spelling Electrocardiographic imaging including intracardiac information to achieve accurate global mapping during atrial fibrillationCámara-Vázquez, Miguel ÁngelHernández-Romero, IsmaelRodrigo, MiguelAlonso-Atienza, FelipeFiguera, CarlosMorgado-Reyes, EduardoAtienza, FelipeBarquero-Pérez, ÓscarGuillem Sánchez, María Salud|||0000-0001-5660-3693Andreu M. Climent|||0000-0002-7260-8811Atrial fibrillationECG imagingInverse problemEpicardial potentialsDominant frequencyRotor locationTECNOLOGIA ELECTRONICA[EN] Atrial fibrillation (AF) is characterized by complex and irregular propagation patterns. Noninvasive electrocardiographic imaging (ECGI) has been tested during AF conditions with promising results. However, current regularization methods face important challenges in this type of unstable electrical activity scenarios. Combination of intracardiac and non-invasive simultaneous recordings could improve ECGI performance and allow real-time global mapping of complex AF patterns. In this work, we propose an ECGI method that incorporates intracardiac measurements as a constraint in a reformulation of the classical Tikhonov method. We used realistic mathematical models of atria and torso that simulates a wide number of epicardial electrical activity patterns. Body surface potentials were obtained from simulated electrograms (EGMs) by using Boundary Element Method and corrupted with Gaussian noise. Epicardial potentials were estimated using inverse problem with Tikhonov regularization, including intracavitary information as a second constraint. Results showed that first-order Constrained Tikhonov formulation provided more reliable reconstructions than the classical Tikhonov approach in AF conditions using at least 32 uniformly distributed endocardial EGMs (CC between 0.87 and 0.28, depending on the AF complexity). Constrained Tikhonov provided more accurate spatial mass functions (SMF) of PS locations (CC smF between 0.24 and 0.86). This methodology was tested on real patient data, obtaining a mean DF RMSE of 0.85 Hz, outperforming the classical Tikhonov approach. Limitations of this study include the fact that the model considered endocardium and epicardium as a single layer. Further research will include endocardium-epicardium bilayer model approximations and validation using more real patient data.This work has been partially supported by projects TEC2016-75361R and PID2019-105032GB-I00 from the Spanish Ministry of Economy and Spanish Ministry of Science and Innovation, respectively, projects IJCI-2014-22178, PI16-01123, DTS16/00160, PI17/0159, PI17/01106 from the Spanish Ministry of Economy through the Carlos III Health Institute with FEDER founds, grant GVA APOSTD/2017/068 and projects AICO/2018/267, GV/2018/103 from the Education, Research, Culture and Sports department of Generalitat Valenciana, Spain.ElsevierDepartamento de Ingeniería ElectrónicaEscuela Técnica Superior de Ingeniería de TelecomunicaciónInstituto Universitario de Tecnologías de la Información y ComunicacionesGeneralitat ValencianaInstituto de Salud Carlos IIIAgencia Estatal de InvestigaciónEuropean Regional Development FundMinisterio de Economía y CompetitividadRepositorio Institucional de la Universitat Politècnica de València Riunet20212021-02-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://riunet.upv.es/handle/10251/183497reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2019-105032GB-I00 PROCESAMIENTO DE SEÑAL PARA DATOS DEFINIDOS SOBRE GRAFOS: APROVECHANDO LA ESTRUCTURA EN DOMINIOS IRREGULARESMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 TEC2016-75361-RMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 DTS16%2F00160 Guiado en Tiempo Real de la Ablación de la Fibrilación Auricular mediante Cartografía Eléctrica Global (CORIFY)Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17%2F01059Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 IJCI-2014-22178 IJCI-2014-22178Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17%2F01106Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 PI16%2F01123 Regeneración Cardiaca de Infarto Crónico Porcino mediante Inyecciónes Intramiocardiacas de Células Progenitoras Embebidas en Hidrogeles de Matriz DecelularizadaGeneralitat Valenciana https://doi.org/10.13039/501100003359 APOSTD%2F2017%2F068 Estratificación multiparamétrica de pacientes con fibrilación auricularGeneralitat Valenciana https://doi.org/10.13039/501100003359 GV%2F2018%2F103 MODELOS IN-SILICO PARA LA PERSONALIZACION DE TERAPIAS EN FIBRILACION AURICULARGeneralitat Valenciana https://doi.org/10.13039/501100003359 AICO%2F2018%2F267 TECNOLOGIAS DE IMAGEN ELECTROCARDIOGRAFICA PARA LA PERSONALIZACION DE LOS TRATAMIENTOS PARA FIBRILACION AURICULARopen accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/1834972026-06-13T07:49:27Z
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