Variation in Human Milk Composition Is Related to Differences in Milk and Infant Fecal Microbial Communities

Previously published data from our group and others demonstrate that human milk oligosaccharide (HMOs), as well as milk and infant fecal microbial profiles, vary by geography. However, little is known about the geographical variation of other milk-borne factors, such as lactose and protein, as well...

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Detalles Bibliográficos
Autores: Pace, Ryan M., Williams, Janet E., Robertson, Bianca, Lackey, Kimberly A., Meehan, Courtney L., Price, William J., Foster, James A., Sellen, Daniel W., Kamau Mbuthia, Elizabeth W., Kamundia, Egidioh W., Mbugua, Samwel, Moore, Sophie E., Prentice, Andrew M., Kita, Debela G., Kvist, Linda J., Otoo, Gloria E., Ruiz, Lorena, Rodríguez, Juan M., Pareja, Rossina G., McGuire, Mark A., Bode, Lars, McGuire, Michelle K.
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/7376
Acceso en línea:https://hdl.handle.net/20.500.14352/7376
Access Level:acceso abierto
Palabra clave:bacteria
breastmilk
gastrointestinal tract
HMO
human milk
infant
lactose
microbiome
oligosaccharides
protein
Nutrición
Dietética y nutrición (Farmacia)
Tecnología de los alimentos
3206 Ciencias de la Nutrición
3309 Tecnología de Los Alimentos
Descripción
Sumario:Previously published data from our group and others demonstrate that human milk oligosaccharide (HMOs), as well as milk and infant fecal microbial profiles, vary by geography. However, little is known about the geographical variation of other milk-borne factors, such as lactose and protein, as well as the associations among these factors and microbial community structures in milk and infant feces. Here, we characterized and contrasted concentrations of milk-borne lactose, protein, and HMOs, and examined their associations with milk and infant fecal microbiomes in samples collected in 11 geographically diverse sites. Although geographical site was strongly associated with milk and infant fecal microbiomes, both sample types assorted into a smaller number of community state types based on shared microbial profiles. Similar to HMOs, concentrations of lactose and protein also varied by geography. Concentrations of HMOs, lactose, and protein were associated with differences in the microbial community structures of milk and infant feces and in the abundance of specific taxa. Taken together, these data suggest that the composition of human milk, even when produced by relatively healthy women, differs based on geographical boundaries and that concentrations of HMOs, lactose, and protein in milk are related to variation in milk and infant fecal microbial communities.

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