A reduction in sedentary behaviour in obese women during pregnancy reduces neonatal adiposity: the DALI randomised controlled trial

Aims/hypothesis Offspring of obese women are at increased risk of features of the metabolic syndrome, including obesity and diabetes. Lifestyle intervention in pregnancy might reduce adverse effects of maternal obesity on neonatal adiposity. Methods In the Vitamin D And Lifestyle Intervention for Ge...

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Autores: van Poppel, MNM, Simmons, D, Devlieger, R, van Assche, FA, Jans, G, Galjaard, S, Corcoy, R, Adelantado, JM, Dunne, F, Harreiter, J, Kautzky-Willer, A, Damm, P, Mathiesen, ER, Jensen, DM, Andersen, LL, Tanvig, M, Lapolla, A, Dalfra, MG, Bertolotto, A, Wender-Ozegowska, E, Zawiejska, A, Hill, D, Snoek, FJ, Jelsma, JGM, Desoye, G
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p2665
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2665
http://ddd.uab.cat/record/223032
Access Level:acceso abierto
Palabra clave:Lifestyle intervention
Mediation
Neonatal adiposity
Randomised controlled trial
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spelling A reduction in sedentary behaviour in obese women during pregnancy reduces neonatal adiposity: the DALI randomised controlled trialvan Poppel, MNMSimmons, DDevlieger, Rvan Assche, FAJans, GGaljaard, SCorcoy, RAdelantado, JMDunne, FHarreiter, JKautzky-Willer, ADamm, PMathiesen, ERJensen, DMAndersen, LLTanvig, MLapolla, ADalfra, MGBertolotto, AWender-Ozegowska, EZawiejska, AHill, DSnoek, FJJelsma, JGMDesoye, GLifestyle interventionMediationNeonatal adiposityRandomised controlled trialAims/hypothesis Offspring of obese women are at increased risk of features of the metabolic syndrome, including obesity and diabetes. Lifestyle intervention in pregnancy might reduce adverse effects of maternal obesity on neonatal adiposity. Methods In the Vitamin D And Lifestyle Intervention for Gestational Diabetes Mellitus (GDM) Prevention (DALI) lifestyle trial, 436 women with a BMI >= 29kg/m(2) were randomly assigned to counselling on healthy eating (HE), physical activity (PA) or HE&PA, or to usual care (UC). In secondary analyses of the lifestyle trial, intervention effects on neonatal outcomes (head, abdominal, arm and leg circumferences and skinfold thicknesses, estimated fat mass, fat percentage, fat-free mass and cord blood leptin) were assessed using multilevel regression analyses. Mediation of intervention effects by lifestyle and gestational weight gain was assessed. Results Outcomes were available from 334 neonates. A reduction in sum of skinfolds (-1.8mm; 95% CI -3.5, -0.2; p=0.03), fat mass (-63g; 95% CI -124, -2; p=0.04), fat percentage (-1.2%; 95% CI -2.4%, -0.04%; p=0.04) and leptin (-3.80 mu g/l; 95% CI -7.15, -0.45; p=0.03) was found in the HE&PA group, and reduced leptin in female neonates in the PA group (-5.79 mu g/l; 95% CI -11.43, -0.14; p=0.05) compared with UC. Reduced sedentary time, but not gestational weight gain, mediated intervention effects on leptin in both the HE&PA and PA groups. Conclusions/interpretation The HE&PA intervention resulted in reduced adiposity in neonates. Reduced sedentary time seemed to drive the intervention effect on cord blood leptin. Implications for future adiposity and diabetes risk of the offspring need to be elucidated.SPRINGER2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2665http://ddd.uab.cat/record/223032DIABETOLOGIAISSN: 0012186XISSNe: 14320428reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p26652026-06-14T12:41:47Z
dc.title.none.fl_str_mv A reduction in sedentary behaviour in obese women during pregnancy reduces neonatal adiposity: the DALI randomised controlled trial
title A reduction in sedentary behaviour in obese women during pregnancy reduces neonatal adiposity: the DALI randomised controlled trial
spellingShingle A reduction in sedentary behaviour in obese women during pregnancy reduces neonatal adiposity: the DALI randomised controlled trial
van Poppel, MNM
Lifestyle intervention
Mediation
Neonatal adiposity
Randomised controlled trial
title_short A reduction in sedentary behaviour in obese women during pregnancy reduces neonatal adiposity: the DALI randomised controlled trial
title_full A reduction in sedentary behaviour in obese women during pregnancy reduces neonatal adiposity: the DALI randomised controlled trial
title_fullStr A reduction in sedentary behaviour in obese women during pregnancy reduces neonatal adiposity: the DALI randomised controlled trial
title_full_unstemmed A reduction in sedentary behaviour in obese women during pregnancy reduces neonatal adiposity: the DALI randomised controlled trial
title_sort A reduction in sedentary behaviour in obese women during pregnancy reduces neonatal adiposity: the DALI randomised controlled trial
dc.creator.none.fl_str_mv van Poppel, MNM
Simmons, D
Devlieger, R
van Assche, FA
Jans, G
Galjaard, S
Corcoy, R
Adelantado, JM
Dunne, F
Harreiter, J
Kautzky-Willer, A
Damm, P
Mathiesen, ER
Jensen, DM
Andersen, LL
Tanvig, M
Lapolla, A
Dalfra, MG
Bertolotto, A
Wender-Ozegowska, E
Zawiejska, A
Hill, D
Snoek, FJ
Jelsma, JGM
Desoye, G
author van Poppel, MNM
author_facet van Poppel, MNM
Simmons, D
Devlieger, R
van Assche, FA
Jans, G
Galjaard, S
Corcoy, R
Adelantado, JM
Dunne, F
Harreiter, J
Kautzky-Willer, A
Damm, P
Mathiesen, ER
Jensen, DM
Andersen, LL
Tanvig, M
Lapolla, A
Dalfra, MG
Bertolotto, A
Wender-Ozegowska, E
Zawiejska, A
Hill, D
Snoek, FJ
Jelsma, JGM
Desoye, G
author_role author
author2 Simmons, D
Devlieger, R
van Assche, FA
Jans, G
Galjaard, S
Corcoy, R
Adelantado, JM
Dunne, F
Harreiter, J
Kautzky-Willer, A
Damm, P
Mathiesen, ER
Jensen, DM
Andersen, LL
Tanvig, M
Lapolla, A
Dalfra, MG
Bertolotto, A
Wender-Ozegowska, E
Zawiejska, A
Hill, D
Snoek, FJ
Jelsma, JGM
Desoye, G
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Lifestyle intervention
Mediation
Neonatal adiposity
Randomised controlled trial
topic Lifestyle intervention
Mediation
Neonatal adiposity
Randomised controlled trial
description Aims/hypothesis Offspring of obese women are at increased risk of features of the metabolic syndrome, including obesity and diabetes. Lifestyle intervention in pregnancy might reduce adverse effects of maternal obesity on neonatal adiposity. Methods In the Vitamin D And Lifestyle Intervention for Gestational Diabetes Mellitus (GDM) Prevention (DALI) lifestyle trial, 436 women with a BMI >= 29kg/m(2) were randomly assigned to counselling on healthy eating (HE), physical activity (PA) or HE&PA, or to usual care (UC). In secondary analyses of the lifestyle trial, intervention effects on neonatal outcomes (head, abdominal, arm and leg circumferences and skinfold thicknesses, estimated fat mass, fat percentage, fat-free mass and cord blood leptin) were assessed using multilevel regression analyses. Mediation of intervention effects by lifestyle and gestational weight gain was assessed. Results Outcomes were available from 334 neonates. A reduction in sum of skinfolds (-1.8mm; 95% CI -3.5, -0.2; p=0.03), fat mass (-63g; 95% CI -124, -2; p=0.04), fat percentage (-1.2%; 95% CI -2.4%, -0.04%; p=0.04) and leptin (-3.80 mu g/l; 95% CI -7.15, -0.45; p=0.03) was found in the HE&PA group, and reduced leptin in female neonates in the PA group (-5.79 mu g/l; 95% CI -11.43, -0.14; p=0.05) compared with UC. Reduced sedentary time, but not gestational weight gain, mediated intervention effects on leptin in both the HE&PA and PA groups. Conclusions/interpretation The HE&PA intervention resulted in reduced adiposity in neonates. Reduced sedentary time seemed to drive the intervention effect on cord blood leptin. Implications for future adiposity and diabetes risk of the offspring need to be elucidated.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2665
http://ddd.uab.cat/record/223032
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2665
http://ddd.uab.cat/record/223032
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SPRINGER
publisher.none.fl_str_mv SPRINGER
dc.source.none.fl_str_mv DIABETOLOGIA
ISSN: 0012186X
ISSNe: 14320428
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,30478

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