Synthetic Haptens and Enantioselective Monoclonal Antibodies to the Cyanotoxin Anatoxin‐a

Early warning systems for monitoring toxic events may benefit from the availability of monoclonal antibodies enabling the sensitive and specific detection of anatoxin‐a, a cyanotoxin involved in numerous cases of animal poisoning due to toxic algal blooms in freshwaters. Through the synthesis of thr...

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Detalhes bibliográficos
Autores: Quiñones Reyes, Guillermo, Agulló, Consuelo, Mercader Badia, Josep Vicent, Abad Somovilla, Antonio, Abad Fuentes, Antonio
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/181603
Acesso em linha:http://hdl.handle.net/10261/181603
Access Level:acceso abierto
Palavra-chave:Hapten design
Rapid methods
Biotoxins
Antibodies
Immunoassays
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spelling Synthetic Haptens and Enantioselective Monoclonal Antibodies to the Cyanotoxin Anatoxin‐aQuiñones Reyes, GuillermoAgulló, ConsueloMercader Badia, Josep VicentAbad Somovilla, AntonioAbad Fuentes, AntonioHapten designRapid methodsBiotoxinsAntibodiesImmunoassaysEarly warning systems for monitoring toxic events may benefit from the availability of monoclonal antibodies enabling the sensitive and specific detection of anatoxin‐a, a cyanotoxin involved in numerous cases of animal poisoning due to toxic algal blooms in freshwaters. Through the synthesis of three functionalized derivatives of anatoxin‐a, we have succeeded in generating the first‐ever reported immunoreagents (bioconjugates and antibodies) suitable for the development of immunoanalytical approaches aimed at rapid and onsite detection of this harmful cyanotoxin.The authors declare no conflict of interest. The immunoreagents herein reported are available upon request for evaluation and research purposes. These developments have been patented (WO2017085339A1) and an exclusive license has been granted to Abraxis, Inc (Pennsylvannia, USA) for the production and commercialization of immunoanalytical methods for anatoxin-a.Peer reviewedWiley-VCHGesellschaft Deutscher ChemikerConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201920192019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/181603reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1002/anie.201904002Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1816032026-05-22T06:33:51Z
dc.title.none.fl_str_mv Synthetic Haptens and Enantioselective Monoclonal Antibodies to the Cyanotoxin Anatoxin‐a
title Synthetic Haptens and Enantioselective Monoclonal Antibodies to the Cyanotoxin Anatoxin‐a
spellingShingle Synthetic Haptens and Enantioselective Monoclonal Antibodies to the Cyanotoxin Anatoxin‐a
Quiñones Reyes, Guillermo
Hapten design
Rapid methods
Biotoxins
Antibodies
Immunoassays
title_short Synthetic Haptens and Enantioselective Monoclonal Antibodies to the Cyanotoxin Anatoxin‐a
title_full Synthetic Haptens and Enantioselective Monoclonal Antibodies to the Cyanotoxin Anatoxin‐a
title_fullStr Synthetic Haptens and Enantioselective Monoclonal Antibodies to the Cyanotoxin Anatoxin‐a
title_full_unstemmed Synthetic Haptens and Enantioselective Monoclonal Antibodies to the Cyanotoxin Anatoxin‐a
title_sort Synthetic Haptens and Enantioselective Monoclonal Antibodies to the Cyanotoxin Anatoxin‐a
dc.creator.none.fl_str_mv Quiñones Reyes, Guillermo
Agulló, Consuelo
Mercader Badia, Josep Vicent
Abad Somovilla, Antonio
Abad Fuentes, Antonio
author Quiñones Reyes, Guillermo
author_facet Quiñones Reyes, Guillermo
Agulló, Consuelo
Mercader Badia, Josep Vicent
Abad Somovilla, Antonio
Abad Fuentes, Antonio
author_role author
author2 Agulló, Consuelo
Mercader Badia, Josep Vicent
Abad Somovilla, Antonio
Abad Fuentes, Antonio
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Hapten design
Rapid methods
Biotoxins
Antibodies
Immunoassays
topic Hapten design
Rapid methods
Biotoxins
Antibodies
Immunoassays
description Early warning systems for monitoring toxic events may benefit from the availability of monoclonal antibodies enabling the sensitive and specific detection of anatoxin‐a, a cyanotoxin involved in numerous cases of animal poisoning due to toxic algal blooms in freshwaters. Through the synthesis of three functionalized derivatives of anatoxin‐a, we have succeeded in generating the first‐ever reported immunoreagents (bioconjugates and antibodies) suitable for the development of immunoanalytical approaches aimed at rapid and onsite detection of this harmful cyanotoxin.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/181603
url http://hdl.handle.net/10261/181603
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1002/anie.201904002
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley-VCH
Gesellschaft Deutscher Chemiker
publisher.none.fl_str_mv Wiley-VCH
Gesellschaft Deutscher Chemiker
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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