Identification and characterization of the dermal Panniculus carnosus muscle stem cells

et al.

Detalhes bibliográficos
Autores: Naldaiz-Gastesi, Neia, López-Mayorga, Macarena, Herrero, Diego, Bernad, Antonio, García-Verdugo, José Manuel, Carvajal, Jaime J., López de Munain, Adolfo, García-Parra, Patricia, Izeta, Ander
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/163326
Acesso em linha:http://hdl.handle.net/10261/163326
Access Level:acceso abierto
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spelling Identification and characterization of the dermal Panniculus carnosus muscle stem cellsNaldaiz-Gastesi, NeiaLópez-Mayorga, MacarenaHerrero, DiegoBernad, AntonioGarcía-Verdugo, José ManuelCarvajal, Jaime J.López de Munain, AdolfoGarcía-Parra, PatriciaIzeta, Anderet al.The dermal Panniculus carnosus (PC) muscle is important for wound contraction in lower mammals and represents an interesting model of muscle regeneration due to its high cell turnover. The resident satellite cells (the bona fide muscle stem cells) remain poorly characterized. Here we analyzed PC satellite cells with regard to developmental origin and purported function. Lineage tracing shows that they originate in Myf5, Pax3/Pax7 cell populations. Skin and muscle wounding increased PC myofiber turnover, with the satellite cell progeny being involved in muscle regeneration but with no detectable contribution to the wound-bed myofibroblasts. Since hematopoietic stem cells fuse to PC myofibers in the absence of injury, we also studied the contribution of bone marrow-derived cells to the PC satellite cell compartment, demonstrating that cells of donor origin are capable of repopulating the PC muscle stem cell niche after irradiation and bone marrow transplantation but may not fully acquire the relevant myogenic commitment.This work was supported by grants from Instituto de Salud Carlos III (ISCIII; PS09/00660, PI13/02172, and PI14/7436), Gobierno Vasco (SAIO12-PE12BN008) from Spain and the European Union (POCTEFA-INTERREG IV A program; REFBIO13/BIOD/006 and REFBIO13/BIOD/009). N.N.G. received a studentship from the Department of Education, University and Research of the Basque Government (PRE2013-1-1168). P.G.P. received fellowships from the Department of Health of the Basque government (2013011016), EMBO (Short-Term; ASTF 542–2013), and Boehringer Ingelheim Fonds. M.L.M. and J.J.C. were supported by a Marie Curie Career Integration Grant from the European Commission (PEOPLE-CIG/1590). A.I. was supported by the Programa I3SNS (CES09/015) from ISCIII and by Osakidetza-Servicio Vasco de Salud (Spain).Peer ReviewedElsevierCell PressInstituto de Salud Carlos IIIBoehringer Ingelheim FondsEusko JaurlaritzaEuropean CommissionUniversidad del País VascoConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2018201820162018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/163326reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1016/j.stemcr.2016.08.002Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1633262026-05-22T06:33:51Z
dc.title.none.fl_str_mv Identification and characterization of the dermal Panniculus carnosus muscle stem cells
title Identification and characterization of the dermal Panniculus carnosus muscle stem cells
spellingShingle Identification and characterization of the dermal Panniculus carnosus muscle stem cells
Naldaiz-Gastesi, Neia
title_short Identification and characterization of the dermal Panniculus carnosus muscle stem cells
title_full Identification and characterization of the dermal Panniculus carnosus muscle stem cells
title_fullStr Identification and characterization of the dermal Panniculus carnosus muscle stem cells
title_full_unstemmed Identification and characterization of the dermal Panniculus carnosus muscle stem cells
title_sort Identification and characterization of the dermal Panniculus carnosus muscle stem cells
dc.creator.none.fl_str_mv Naldaiz-Gastesi, Neia
López-Mayorga, Macarena
Herrero, Diego
Bernad, Antonio
García-Verdugo, José Manuel
Carvajal, Jaime J.
López de Munain, Adolfo
García-Parra, Patricia
Izeta, Ander
author Naldaiz-Gastesi, Neia
author_facet Naldaiz-Gastesi, Neia
López-Mayorga, Macarena
Herrero, Diego
Bernad, Antonio
García-Verdugo, José Manuel
Carvajal, Jaime J.
López de Munain, Adolfo
García-Parra, Patricia
Izeta, Ander
author_role author
author2 López-Mayorga, Macarena
Herrero, Diego
Bernad, Antonio
García-Verdugo, José Manuel
Carvajal, Jaime J.
López de Munain, Adolfo
García-Parra, Patricia
Izeta, Ander
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
Boehringer Ingelheim Fonds
Eusko Jaurlaritza
European Commission
Universidad del País Vasco
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description et al.
publishDate 2016
dc.date.none.fl_str_mv 2016
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/163326
url http://hdl.handle.net/10261/163326
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1016/j.stemcr.2016.08.002
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
Cell Press
publisher.none.fl_str_mv Elsevier
Cell Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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