SEOM clinical guideline for treatment of muscle-invasive and metastatic urothelial bladder cancer (2018)

Càncer de bufeta; Cistectomia; Quimioteràpia

Detalles Bibliográficos
Autores: Gonzalez-del-Alba, Aranzazu, De Velasco, G., Lainez, N., Maroto, P., Morales Barrera, Rafael, Muñoz‑Langa, J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/5755
Acceso en línea:https://hdl.handle.net/11351/5755
http://hdl.handle.net/11351/5755
Access Level:acceso abierto
Palabra clave:Bufeta - Càncer - Tractament
Metàstasi
DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Urologic Neoplasms::Urinary Bladder Neoplasms
Other subheadings::Other subheadings::/therapy
DISEASES::Neoplasms::Neoplastic Processes::Neoplasm Metastasis
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias urológicas::neoplasias de la vejiga
Otros calificadores::Otros calificadores::/terapia
ENFERMEDADES::neoplasias::procesos neoplásicos::metástasis neoplásica
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network_name_str España
repository_id_str
spelling SEOM clinical guideline for treatment of muscle-invasive and metastatic urothelial bladder cancer (2018)Gonzalez-del-Alba, AranzazuDe Velasco, G.Lainez, N.Maroto, P.Morales Barrera, RafaelMuñoz‑Langa, J.Bufeta - Càncer - TractamentMetàstasiDISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Urologic Neoplasms::Urinary Bladder NeoplasmsOther subheadings::Other subheadings::/therapyDISEASES::Neoplasms::Neoplastic Processes::Neoplasm MetastasisENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias urológicas::neoplasias de la vejigaOtros calificadores::Otros calificadores::/terapiaENFERMEDADES::neoplasias::procesos neoplásicos::metástasis neoplásicaCàncer de bufeta; Cistectomia; QuimioteràpiaCáncer de vejiga; Cistectomía; QuimioterapiaBladder cancer; Cystectomy; ChemotherapyThe goal of this article is to provide recommendations about the management of muscle-invasive (MIBC) and metastatic bladder cancer. New molecular subtypes of MIBC are associated with specific clinical–pathological characteristics. Radical cystectomy and lymph node dissection are the gold standard for treatment and neoadjuvant chemotherapy with a cisplatin-based combination should be recommended in fit patients. The role of adjuvant chemotherapy in MIBC remains controversial; its use must be considered in patients with high-risk who are able to tolerate a cisplatin-based regimen, and have not received neoadjuvant chemotherapy. Bladder-preserving approaches are reasonable alternatives to cystectomy in selected patients for whom cystectomy is not contemplated either for clinical or personal reasons. Cisplatin-based combination chemotherapy is the standard first-line protocol for metastatic disease. In the case of unfit patients, carboplatin–gemcitabine should be considered the preferred first-line chemotherapy treatment option, while pembrolizumab and atezolizumab can be contemplated for individuals with high PD-L1 expression. In cases of progression after platinum-based therapy, PD-1/PD-L1 inhibitors are standard alternatives. Vinflunine is another option when anti-PD-1/PD-L1 therapy is not possible. There are no data from randomized clinical trials regarding moving on to immuno-oncology agents.Springer[González Del Alba A] Medical Oncology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Joaquin Rodrigo 2, 28222 Majadahonda, Madrid, Spain. [De Velasco G] Medical Oncology Department, Hospital Universitario Doce de Octubre, Madrid, Spain. [Lainez N] Medical Oncology Department, Complejo Hospitalario de Navarra, Pamplona, Spain. [Maroto P] Medical Oncology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. [Morales-Barrera R] Genitourinary, CNS and Sarcoma Tumors Program, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Muñoz-Langa J] Medical Oncology Department, Hospital Universitari I Politècnic la Fe, Valencia, SpainVall d'Hebron Barcelona Hospital Campus202120212019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/5755http://hdl.handle.net/11351/5755Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésClinical and Translational Oncology;21https://link.springer.com/article/10.1007%2Fs12094-018-02001-xAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/57552026-05-29T05:05:01Z
dc.title.none.fl_str_mv SEOM clinical guideline for treatment of muscle-invasive and metastatic urothelial bladder cancer (2018)
title SEOM clinical guideline for treatment of muscle-invasive and metastatic urothelial bladder cancer (2018)
spellingShingle SEOM clinical guideline for treatment of muscle-invasive and metastatic urothelial bladder cancer (2018)
Gonzalez-del-Alba, Aranzazu
Bufeta - Càncer - Tractament
Metàstasi
DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Urologic Neoplasms::Urinary Bladder Neoplasms
Other subheadings::Other subheadings::/therapy
DISEASES::Neoplasms::Neoplastic Processes::Neoplasm Metastasis
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias urológicas::neoplasias de la vejiga
Otros calificadores::Otros calificadores::/terapia
ENFERMEDADES::neoplasias::procesos neoplásicos::metástasis neoplásica
title_short SEOM clinical guideline for treatment of muscle-invasive and metastatic urothelial bladder cancer (2018)
title_full SEOM clinical guideline for treatment of muscle-invasive and metastatic urothelial bladder cancer (2018)
title_fullStr SEOM clinical guideline for treatment of muscle-invasive and metastatic urothelial bladder cancer (2018)
title_full_unstemmed SEOM clinical guideline for treatment of muscle-invasive and metastatic urothelial bladder cancer (2018)
title_sort SEOM clinical guideline for treatment of muscle-invasive and metastatic urothelial bladder cancer (2018)
dc.creator.none.fl_str_mv Gonzalez-del-Alba, Aranzazu
De Velasco, G.
Lainez, N.
Maroto, P.
Morales Barrera, Rafael
Muñoz‑Langa, J.
author Gonzalez-del-Alba, Aranzazu
author_facet Gonzalez-del-Alba, Aranzazu
De Velasco, G.
Lainez, N.
Maroto, P.
Morales Barrera, Rafael
Muñoz‑Langa, J.
author_role author
author2 De Velasco, G.
Lainez, N.
Maroto, P.
Morales Barrera, Rafael
Muñoz‑Langa, J.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv [González Del Alba A] Medical Oncology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Joaquin Rodrigo 2, 28222 Majadahonda, Madrid, Spain. [De Velasco G] Medical Oncology Department, Hospital Universitario Doce de Octubre, Madrid, Spain. [Lainez N] Medical Oncology Department, Complejo Hospitalario de Navarra, Pamplona, Spain. [Maroto P] Medical Oncology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. [Morales-Barrera R] Genitourinary, CNS and Sarcoma Tumors Program, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Muñoz-Langa J] Medical Oncology Department, Hospital Universitari I Politècnic la Fe, Valencia, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Bufeta - Càncer - Tractament
Metàstasi
DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Urologic Neoplasms::Urinary Bladder Neoplasms
Other subheadings::Other subheadings::/therapy
DISEASES::Neoplasms::Neoplastic Processes::Neoplasm Metastasis
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias urológicas::neoplasias de la vejiga
Otros calificadores::Otros calificadores::/terapia
ENFERMEDADES::neoplasias::procesos neoplásicos::metástasis neoplásica
topic Bufeta - Càncer - Tractament
Metàstasi
DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Urologic Neoplasms::Urinary Bladder Neoplasms
Other subheadings::Other subheadings::/therapy
DISEASES::Neoplasms::Neoplastic Processes::Neoplasm Metastasis
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias urológicas::neoplasias de la vejiga
Otros calificadores::Otros calificadores::/terapia
ENFERMEDADES::neoplasias::procesos neoplásicos::metástasis neoplásica
description Càncer de bufeta; Cistectomia; Quimioteràpia
publishDate 2019
dc.date.none.fl_str_mv 2019
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/5755
http://hdl.handle.net/11351/5755
url https://hdl.handle.net/11351/5755
http://hdl.handle.net/11351/5755
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Clinical and Translational Oncology;21
https://link.springer.com/article/10.1007%2Fs12094-018-02001-x
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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