The buckwheat iminosugar d-fagomine attenuates sucrose-induced steatosis and hypertension in rats

Scope: This study examines the long-term functional effects of D-fagomine on sucrose4 induced factors of metabolic dysfunctions and explores possible molecular mechanisms behind its action. Methods & results: Wistar Kyoto (WKY) rats were fed a 35% sucrose solution with D- fagomine (or not, for c...

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Authors: Ramos Romero, Sara, Hereu, Mercè, Atienza, Lidia, Amézqueta, Susana, Casas, Josefina, Muñoz, Silvia, Medina, Isabel, Miralles-Pérez, Bernat, Romeu Ferran, Marta, Torres, Josep Lluís
Format: article
Status:Versión aceptada para publicación
Publication Date:2019
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/162326
Online Access:https://hdl.handle.net/2445/162326
Access Level:Open access
Keyword:Metagenòmica
Obesitat
Diabetis
Pressió sanguínia
Metagenomics
Obesity
Diabetes
Blood pressure
Description
Summary:Scope: This study examines the long-term functional effects of D-fagomine on sucrose4 induced factors of metabolic dysfunctions and explores possible molecular mechanisms behind its action. Methods & results: Wistar Kyoto (WKY) rats were fed a 35% sucrose solution with D- fagomine (or not, for comparison) or mineral water (controls) for 24 weeks. We recorded: body weight; energy intake; glucose tolerance; plasma leptin concentration and lipid profile; populations of Bacteroidetes, Firmicutes, bacteroidales, clostridiales, enterobacteriales, and Escherichia coli in feces; blood pressure; urine uric acid and F2t isoprostanes (F2-IsoPs); perigonadal fat deposition; and hepatic histology and diacylglycerols (DAGs) in liver and adipose tissue. D-Fagomine reduced sucrose-induced hypertension, urine uric acid and F2-IsoPs (markers of oxidative stress; OS), steatosis and liver DAGs, without significantly affecting perigonadal fat deposition and impaired glucose tolerance. It also promoted excretion of enterobacteriales generated by the dietary intervention. Conclusion: D-fagomine counteracts sucrose-induced steatosis and hypertension, presumably by reducing the postprandial levels of fructose in the liver.

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