A myxoid fibrotic reaction pattern is associated with metastatic risk in cutaneous squamous cell carcinoma

Although desmoplasia has been associated with poor prognoses in cutaneous squamous cell carcinoma, little attention has been paid to the patterns of fibrosis. This study aimed to examine the different stromal fibrotic patterns as markers of metastatic risk. We performed a multicenter retrospective s...

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Detalles Bibliográficos
Autores: Hernández-Ruiz, Eugenia, Hernández-Muñoz, Inmaculada, Masferrer i Niubò, Emili|||0000-0002-0763-2815, Ferrandiz-Pulido, Carla|||0000-0003-3688-9596, Andrades, Evelyn|||0000-0003-2166-6760, Gimeno Beltran, Javier|||0000-0001-6085-5228, Duran-Jordà, Xavier|||0000-0001-8517-9254, García-Patos Briones, Vicente|||0000-0003-1654-6035, Pujol Vallverdú, Ramón M|||0000-0002-5622-6055, Toll Abelló, Agustí
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:222950
Acceso en línea:https://ddd.uab.cat/record/222950
https://dx.doi.org/urn:doi:10.2340/00015555-3025
Access Level:acceso abierto
Palabra clave:Metastasis
Fibrosis
Cutaneous squamous cell carcinoma
Descripción
Sumario:Although desmoplasia has been associated with poor prognoses in cutaneous squamous cell carcinoma, little attention has been paid to the patterns of fibrosis. This study aimed to examine the different stromal fibrotic patterns as markers of metastatic risk. We performed a multicenter retrospective study that included 102 cutaneous squamous cell carcinomas (52 non-metastatic and 50 metastatic carcinomas). Clinical and histopathological data were registered. The fibrotic reaction pattern was classified as mature, intermediate or immature depending on the presence of keloid-like collagen and myxoid stroma. The immature pattern (areas characterized by myxoid changes with no inflamma-tion) was observed in 18 samples and its presence was significantly associated with immunosuppression, budding, desmoplasia, perineural invasion, anatomic level, tumoural depth and metastatic risk in the multivariate analysis. Our findings suggest that the presence of an immature myxoid fibrotic pattern, which can be easily identified by routine hematoxylin-eosin staining, is strongly associated with metastatic risk.

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