Human pluripotent stem cells to model islet defects in diabetes

Diabetes mellitus is characterized by elevated levels of blood glucose and is ultimately caused by insufficient insulin production from pancreatic beta cells. Different research models have been utilized to unravel the molecular mechanisms leading to the onset of diabetes. The generation of pancreat...

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Authors: Balboa, Diego, Iworima, Diepiriye G., Kieffer, Timothy J.
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Universitat Pompeu Fabra
Repository:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/48112
Online Access:http://hdl.handle.net/10230/48112
http://dx.doi.org/10.3389/fendo.2021.642152
Access Level:Open access
Keyword:Diabetis
Insulina
Genètica
Pàncrees
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spelling Human pluripotent stem cells to model islet defects in diabetesBalboa, DiegoIworima, Diepiriye G.Kieffer, Timothy J.DiabetisInsulinaGenèticaPàncreesDiabetes mellitus is characterized by elevated levels of blood glucose and is ultimately caused by insufficient insulin production from pancreatic beta cells. Different research models have been utilized to unravel the molecular mechanisms leading to the onset of diabetes. The generation of pancreatic endocrine cells from human pluripotent stem cells constitutes an approach to study genetic defects leading to impaired beta cell development and function. Here, we review the recent progress in generating and characterizing functional stem cell-derived beta cells. We summarize the diabetes disease modeling possibilities that stem cells offer and the challenges that lie ahead to further improve these models.DB gratefully acknowledges funding support by EMBO long-term fellowship (ALTF 295-2019). DI gratefully acknowledges funding support by the Natural Science and Engineering Research Council, and Canadian Federation of University WomenFrontiers Media202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/48112http://dx.doi.org/10.3389/fendo.2021.642152reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglés© 2021 Balboa, Iworima and Kieffer. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these termshttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/481122026-06-12T07:21:37Z
dc.title.none.fl_str_mv Human pluripotent stem cells to model islet defects in diabetes
title Human pluripotent stem cells to model islet defects in diabetes
spellingShingle Human pluripotent stem cells to model islet defects in diabetes
Balboa, Diego
Diabetis
Insulina
Genètica
Pàncrees
title_short Human pluripotent stem cells to model islet defects in diabetes
title_full Human pluripotent stem cells to model islet defects in diabetes
title_fullStr Human pluripotent stem cells to model islet defects in diabetes
title_full_unstemmed Human pluripotent stem cells to model islet defects in diabetes
title_sort Human pluripotent stem cells to model islet defects in diabetes
dc.creator.none.fl_str_mv Balboa, Diego
Iworima, Diepiriye G.
Kieffer, Timothy J.
author Balboa, Diego
author_facet Balboa, Diego
Iworima, Diepiriye G.
Kieffer, Timothy J.
author_role author
author2 Iworima, Diepiriye G.
Kieffer, Timothy J.
author2_role author
author
dc.subject.none.fl_str_mv Diabetis
Insulina
Genètica
Pàncrees
topic Diabetis
Insulina
Genètica
Pàncrees
description Diabetes mellitus is characterized by elevated levels of blood glucose and is ultimately caused by insufficient insulin production from pancreatic beta cells. Different research models have been utilized to unravel the molecular mechanisms leading to the onset of diabetes. The generation of pancreatic endocrine cells from human pluripotent stem cells constitutes an approach to study genetic defects leading to impaired beta cell development and function. Here, we review the recent progress in generating and characterizing functional stem cell-derived beta cells. We summarize the diabetes disease modeling possibilities that stem cells offer and the challenges that lie ahead to further improve these models.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/48112
http://dx.doi.org/10.3389/fendo.2021.642152
url http://hdl.handle.net/10230/48112
http://dx.doi.org/10.3389/fendo.2021.642152
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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