Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors

Rudolph, A.; Milne, R. L.; Truong, T.; Knight, J. A.; Seibold, P.; Flesch-Janys, D.; Behrens, S.; Eilber, U.; Bolla, M. K.; Wang, Q.; Dennis, J.; Dunning, A. M.; Shah, M.; Munday, H. R.; Darabi, H.; Eriksson, M.; Brand, J. S.; Olson, J.; Vachon, C. M.; Hallberg, E.; Castelao, J. E.; Carracedo, A.; Torres, M.; Li, J.; Humphreys, K.; Cordina-Duverger, E.; Menegaux, F.; Flyger, H.; Nordestgaard, B. G.; Nielsen, S. F.; Yesilyurt, B. T.; Floris, G.; Leunen, K.; Engelhardt, E. G.; Broeks, A.; Rutgers, E. J.; Glendon, G.; Mulligan, A. M.; Cross, S.; Reed, M.; Gonzalez-Neira, A.; Perez, J. I. A.; Provenzano, E.; Apicella, C.; Southey, M. C.; Spurdle, A.; Häberle, L.; Beckmann, M. W.; Ekici, A. B.; Dieffenbach, A. K.; Arndt, V.; Stegmaier, C.; McLean, C.; Baglietto, L.; Chanock, S. J.; Lissowska, J.; Sherman, M. E.; Brüning, T.; Hamann, U.; Ko, Y. D.; Orr, N.; Schoemaker, M.; Ashworth, A.; Kosma, V. M.; Kataja, V.; Hartikainen, J. M.; Mannermaa, A.; Swerdlow, A.; Giles, G. G.; Brenner, H.; Fasching, P. A.; Chenevix-Trench, G.; Hopper, J.; Benítez, J.; Cox, A.; Andrulis, I. L.; Lambrechts, D.; Gago-Dominguez, M.; Couch, F.; Czene, K.; Bojesen, S. E.; Easton, D. F.; Schmidt, M. K.; Guénel, P.; Hall, P.; Pharoah, P. D. P.; Garcia-Closas, M.; Chang-Claude, J.

Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors

A large genotyping project within the Breast Cancer Association Consortium (BCAC) recently identified 41 associations between single nucleotide polymorphisms (SNPs) and overall breast cancer (BC) risk. We investigated whether the effects of these 41 SNPs, as well as six SNPs associated with estrogen...

Descripción completa

Detalles Bibliográficos
Autores:	Rudolph, A., Milne, R. L., Truong, T., Knight, J. A., Seibold, P., Flesch-Janys, D., Behrens, S., Eilber, U., Bolla, M. K., Wang, Q., Dennis, J., Dunning, A. M., Shah, M., Munday, H. R., Darabi, H., Eriksson, M., Brand, J. S., Olson, J., Vachon, C. M., Hallberg, E., Castelao, J. E., Carracedo, A., Torres, M., Li, J., Humphreys, K., Cordina-Duverger, E., Menegaux, F., Flyger, H., Nordestgaard, B. G., Nielsen, S. F., Yesilyurt, B. T., Floris, G., Leunen, K., Engelhardt, E. G., Broeks, A., Rutgers, E. J., Glendon, G., Mulligan, A. M., Cross, S., Reed, M., Gonzalez-Neira, A., Perez, J. I. A., Provenzano, E., Apicella, C., Southey, M. C., Spurdle, A., Häberle, L., Beckmann, M. W., Ekici, A. B., Dieffenbach, A. K., Arndt, V., Stegmaier, C., McLean, C., Baglietto, L., Chanock, S. J., Lissowska, J., Sherman, M. E., Brüning, T., Hamann, U., Ko, Y. D., Orr, N., Schoemaker, M., Ashworth, A., Kosma, V. M., Kataja, V., Hartikainen, J. M., Mannermaa, A., Swerdlow, A., Giles, G. G., Brenner, H., Fasching, P. A., Chenevix-Trench, G., Hopper, J., Benítez, J., Cox, A., Andrulis, I. L., Lambrechts, D., Gago-Dominguez, M., Couch, F., Czene, K., Bojesen, S. E., Easton, D. F., Schmidt, M. K., Guénel, P., Hall, P., Pharoah, P. D. P., Garcia-Closas, M., Chang-Claude, J.
Tipo de recurso:	artículo
Fecha de publicación:	2015
País:	España
Institución:	Servizo Galego de Saúde (SERGAS)
Repositorio:	RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:	oai:runa.sergas.gal:20.500.11940/5541
Acceso en línea:	http://hdl.handle.net/20.500.11940/5541
Access Level:	acceso abierto
Palabra clave:	Breast Neoplasms Female Gene-Environment Interaction Genetic Loci Genetic Predisposition to Disease Humans Polymorphism, Single Nucleotide Receptors, Estrogen Risk Factors

id	ES_f3ce8914b233bebdd110b761bf94fabe
oai_identifier_str	oai:runa.sergas.gal:20.500.11940/5541
network_acronym_str	ES
network_name_str	España
repository_id_str
spelling	Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factorsRudolph, A.Milne, R. L.Truong, T.Knight, J. A.Seibold, P.Flesch-Janys, D.Behrens, S.Eilber, U.Bolla, M. K.Wang, Q.Dennis, J.Dunning, A. M.Shah, M.Munday, H. R.Darabi, H.Eriksson, M.Brand, J. S.Olson, J.Vachon, C. M.Hallberg, E.Castelao, J. E.Carracedo, A.Torres, M.Li, J.Humphreys, K.Cordina-Duverger, E.Menegaux, F.Flyger, H.Nordestgaard, B. G.Nielsen, S. F.Yesilyurt, B. T.Floris, G.Leunen, K.Engelhardt, E. G.Broeks, A.Rutgers, E. J.Glendon, G.Mulligan, A. M.Cross, S.Reed, M.Gonzalez-Neira, A.Perez, J. I. A.Provenzano, E.Apicella, C.Southey, M. C.Spurdle, A.Häberle, L.Beckmann, M. W.Ekici, A. B.Dieffenbach, A. K.Arndt, V.Stegmaier, C.McLean, C.Baglietto, L.Chanock, S. J.Lissowska, J.Sherman, M. E.Brüning, T.Hamann, U.Ko, Y. D.Orr, N.Schoemaker, M.Ashworth, A.Kosma, V. M.Kataja, V.Hartikainen, J. M.Mannermaa, A.Swerdlow, A.Giles, G. G.Brenner, H.Fasching, P. A.Chenevix-Trench, G.Hopper, J.Benítez, J.Cox, A.Andrulis, I. L.Lambrechts, D.Gago-Dominguez, M.Couch, F.Czene, K.Bojesen, S. E.Easton, D. F.Schmidt, M. K.Guénel, P.Hall, P.Pharoah, P. D. P.Garcia-Closas, M.Chang-Claude, J.Breast NeoplasmsFemaleGene-Environment InteractionGenetic LociGenetic Predisposition to DiseaseHumansPolymorphism, Single NucleotideReceptors, EstrogenRisk FactorsA large genotyping project within the Breast Cancer Association Consortium (BCAC) recently identified 41 associations between single nucleotide polymorphisms (SNPs) and overall breast cancer (BC) risk. We investigated whether the effects of these 41 SNPs, as well as six SNPs associated with estrogen receptor (ER) negative BC risk are modified by 13 environmental risk factors for BC. Data from 22 studies participating in BCAC were pooled, comprising up to 26,633 cases and 30,119 controls. Interactions between SNPs and environmental factors were evaluated using an empirical Bayes-type shrinkage estimator. Six SNPs showed interactions with associated p-values (pint ) <1.1 x 10(-3) . None of the observed interactions was significant after accounting for multiple testing. The Bayesian False Discovery Probability was used to rank the findings, which indicated three interactions as being noteworthy at 1% prior probability of interaction. SNP rs6828523 was associated with increased ER-negative BC risk in women >/=170 cm (OR = 1.22, p = 0.017), but inversely associated with ER-negative BC risk in women <160 cm (OR = 0.83, p = 0.039, pint = 1.9 x 10(-4) ). The inverse association between rs4808801 and overall BC risk was stronger for women who had had four or more pregnancies (OR = 0.85, p = 2.0 x 10(-4) ), and absent in women who had had just one (OR = 0.96, p = 0.19, pint = 6.1 x 10(-4) ). SNP rs11242675 was inversely associated with overall BC risk in never/former smokers (OR = 0.93, p = 2.8 x 10(-5) ), but no association was observed in current smokers (OR = 1.07, p = 0.14, pint = 3.4 x 10(-4) ). In conclusion, recently identified BC susceptibility loci are not strongly modified by established risk factors and the observed potential interactions require confirmation in independent studies.2015info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.11940/5541reponame:RUNA. Repositorio da Consellería de Sanidade e Sergasinstname:Servizo Galego de Saúde (SERGAS)Inglésinfo:eu-repo/semantics/openAccessoai:runa.sergas.gal:20.500.11940/55412026-06-12T08:40:47Z
dc.title.none.fl_str_mv	Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors
title	Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors
spellingShingle	Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors Rudolph, A. Breast Neoplasms Female Gene-Environment Interaction Genetic Loci Genetic Predisposition to Disease Humans Polymorphism, Single Nucleotide Receptors, Estrogen Risk Factors
title_short	Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors
title_full	Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors
title_fullStr	Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors
title_full_unstemmed	Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors
title_sort	Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors
dc.creator.none.fl_str_mv	Rudolph, A. Milne, R. L. Truong, T. Knight, J. A. Seibold, P. Flesch-Janys, D. Behrens, S. Eilber, U. Bolla, M. K. Wang, Q. Dennis, J. Dunning, A. M. Shah, M. Munday, H. R. Darabi, H. Eriksson, M. Brand, J. S. Olson, J. Vachon, C. M. Hallberg, E. Castelao, J. E. Carracedo, A. Torres, M. Li, J. Humphreys, K. Cordina-Duverger, E. Menegaux, F. Flyger, H. Nordestgaard, B. G. Nielsen, S. F. Yesilyurt, B. T. Floris, G. Leunen, K. Engelhardt, E. G. Broeks, A. Rutgers, E. J. Glendon, G. Mulligan, A. M. Cross, S. Reed, M. Gonzalez-Neira, A. Perez, J. I. A. Provenzano, E. Apicella, C. Southey, M. C. Spurdle, A. Häberle, L. Beckmann, M. W. Ekici, A. B. Dieffenbach, A. K. Arndt, V. Stegmaier, C. McLean, C. Baglietto, L. Chanock, S. J. Lissowska, J. Sherman, M. E. Brüning, T. Hamann, U. Ko, Y. D. Orr, N. Schoemaker, M. Ashworth, A. Kosma, V. M. Kataja, V. Hartikainen, J. M. Mannermaa, A. Swerdlow, A. Giles, G. G. Brenner, H. Fasching, P. A. Chenevix-Trench, G. Hopper, J. Benítez, J. Cox, A. Andrulis, I. L. Lambrechts, D. Gago-Dominguez, M. Couch, F. Czene, K. Bojesen, S. E. Easton, D. F. Schmidt, M. K. Guénel, P. Hall, P. Pharoah, P. D. P. Garcia-Closas, M. Chang-Claude, J.
author	Rudolph, A.
author_facet	Rudolph, A. Milne, R. L. Truong, T. Knight, J. A. Seibold, P. Flesch-Janys, D. Behrens, S. Eilber, U. Bolla, M. K. Wang, Q. Dennis, J. Dunning, A. M. Shah, M. Munday, H. R. Darabi, H. Eriksson, M. Brand, J. S. Olson, J. Vachon, C. M. Hallberg, E. Castelao, J. E. Carracedo, A. Torres, M. Li, J. Humphreys, K. Cordina-Duverger, E. Menegaux, F. Flyger, H. Nordestgaard, B. G. Nielsen, S. F. Yesilyurt, B. T. Floris, G. Leunen, K. Engelhardt, E. G. Broeks, A. Rutgers, E. J. Glendon, G. Mulligan, A. M. Cross, S. Reed, M. Gonzalez-Neira, A. Perez, J. I. A. Provenzano, E. Apicella, C. Southey, M. C. Spurdle, A. Häberle, L. Beckmann, M. W. Ekici, A. B. Dieffenbach, A. K. Arndt, V. Stegmaier, C. McLean, C. Baglietto, L. Chanock, S. J. Lissowska, J. Sherman, M. E. Brüning, T. Hamann, U. Ko, Y. D. Orr, N. Schoemaker, M. Ashworth, A. Kosma, V. M. Kataja, V. Hartikainen, J. M. Mannermaa, A. Swerdlow, A. Giles, G. G. Brenner, H. Fasching, P. A. Chenevix-Trench, G. Hopper, J. Benítez, J. Cox, A. Andrulis, I. L. Lambrechts, D. Gago-Dominguez, M. Couch, F. Czene, K. Bojesen, S. E. Easton, D. F. Schmidt, M. K. Guénel, P. Hall, P. Pharoah, P. D. P. Garcia-Closas, M. Chang-Claude, J.
author_role	author
author2	Milne, R. L. Truong, T. Knight, J. A. Seibold, P. Flesch-Janys, D. Behrens, S. Eilber, U. Bolla, M. K. Wang, Q. Dennis, J. Dunning, A. M. Shah, M. Munday, H. R. Darabi, H. Eriksson, M. Brand, J. S. Olson, J. Vachon, C. M. Hallberg, E. Castelao, J. E. Carracedo, A. Torres, M. Li, J. Humphreys, K. Cordina-Duverger, E. Menegaux, F. Flyger, H. Nordestgaard, B. G. Nielsen, S. F. Yesilyurt, B. T. Floris, G. Leunen, K. Engelhardt, E. G. Broeks, A. Rutgers, E. J. Glendon, G. Mulligan, A. M. Cross, S. Reed, M. Gonzalez-Neira, A. Perez, J. I. A. Provenzano, E. Apicella, C. Southey, M. C. Spurdle, A. Häberle, L. Beckmann, M. W. Ekici, A. B. Dieffenbach, A. K. Arndt, V. Stegmaier, C. McLean, C. Baglietto, L. Chanock, S. J. Lissowska, J. Sherman, M. E. Brüning, T. Hamann, U. Ko, Y. D. Orr, N. Schoemaker, M. Ashworth, A. Kosma, V. M. Kataja, V. Hartikainen, J. M. Mannermaa, A. Swerdlow, A. Giles, G. G. Brenner, H. Fasching, P. A. Chenevix-Trench, G. Hopper, J. Benítez, J. Cox, A. Andrulis, I. L. Lambrechts, D. Gago-Dominguez, M. Couch, F. Czene, K. Bojesen, S. E. Easton, D. F. Schmidt, M. K. Guénel, P. Hall, P. Pharoah, P. D. P. Garcia-Closas, M. Chang-Claude, J.
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Breast Neoplasms Female Gene-Environment Interaction Genetic Loci Genetic Predisposition to Disease Humans Polymorphism, Single Nucleotide Receptors, Estrogen Risk Factors
topic	Breast Neoplasms Female Gene-Environment Interaction Genetic Loci Genetic Predisposition to Disease Humans Polymorphism, Single Nucleotide Receptors, Estrogen Risk Factors
description	A large genotyping project within the Breast Cancer Association Consortium (BCAC) recently identified 41 associations between single nucleotide polymorphisms (SNPs) and overall breast cancer (BC) risk. We investigated whether the effects of these 41 SNPs, as well as six SNPs associated with estrogen receptor (ER) negative BC risk are modified by 13 environmental risk factors for BC. Data from 22 studies participating in BCAC were pooled, comprising up to 26,633 cases and 30,119 controls. Interactions between SNPs and environmental factors were evaluated using an empirical Bayes-type shrinkage estimator. Six SNPs showed interactions with associated p-values (pint ) <1.1 x 10(-3) . None of the observed interactions was significant after accounting for multiple testing. The Bayesian False Discovery Probability was used to rank the findings, which indicated three interactions as being noteworthy at 1% prior probability of interaction. SNP rs6828523 was associated with increased ER-negative BC risk in women >/=170 cm (OR = 1.22, p = 0.017), but inversely associated with ER-negative BC risk in women <160 cm (OR = 0.83, p = 0.039, pint = 1.9 x 10(-4) ). The inverse association between rs4808801 and overall BC risk was stronger for women who had had four or more pregnancies (OR = 0.85, p = 2.0 x 10(-4) ), and absent in women who had had just one (OR = 0.96, p = 0.19, pint = 6.1 x 10(-4) ). SNP rs11242675 was inversely associated with overall BC risk in never/former smokers (OR = 0.93, p = 2.8 x 10(-5) ), but no association was observed in current smokers (OR = 1.07, p = 0.14, pint = 3.4 x 10(-4) ). In conclusion, recently identified BC susceptibility loci are not strongly modified by established risk factors and the observed potential interactions require confirmation in independent studies.
publishDate	2015
dc.date.none.fl_str_mv	2015
dc.type.none.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	http://hdl.handle.net/20.500.11940/5541
url	http://hdl.handle.net/20.500.11940/5541
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.source.none.fl_str_mv	reponame:RUNA. Repositorio da Consellería de Sanidade e Sergas instname:Servizo Galego de Saúde (SERGAS)
instname_str	Servizo Galego de Saúde (SERGAS)
reponame_str	RUNA. Repositorio da Consellería de Sanidade e Sergas
collection	RUNA. Repositorio da Consellería de Sanidade e Sergas
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1869424411450277888
score	15.301603

Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors

Similares en LA Referencia