Association between necropsy evidence of disseminated intravascular coagulation and hemostatic variables before death in horses with colic

Background: Disseminated intravascular coagulation (DIC) is frequent in horses with severe gastrointestinal disorders. Postmortem studies have found fibrin microthrombi in tissues of these horses, but studies relating these histopathological findings with antemortem hemostatic data are lacking. Hypo...

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Autores: Cesarini Latorre, Carlota, Cotovio, M., Ríos, José|||0000-0002-0716-8784, Armengou Ruiz, Lara|||0000-0003-4715-7323, José Cunilleras, Eduard|||0000-0002-4536-7717
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:215646
Acceso en línea:https://ddd.uab.cat/record/215646
https://dx.doi.org/urn:doi:10.1111/jvim.13659
Access Level:acceso abierto
Palabra clave:Cavalls
Malalties
Còlic en els cavalls
Coagulopathy
D-dimer
Equine
Thrombi
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spelling Association between necropsy evidence of disseminated intravascular coagulation and hemostatic variables before death in horses with colicCesarini Latorre, CarlotaCotovio, M.Ríos, José|||0000-0002-0716-8784Armengou Ruiz, Lara|||0000-0003-4715-7323José Cunilleras, Eduard|||0000-0002-4536-7717CavallsMalaltiesCòlic en els cavallsCoagulopathyD-dimerEquineThrombiBackground: Disseminated intravascular coagulation (DIC) is frequent in horses with severe gastrointestinal disorders. Postmortem studies have found fibrin microthrombi in tissues of these horses, but studies relating these histopathological findings with antemortem hemostatic data are lacking. Hypothesis: Antemortem classification of coagulopathy is related to the presence and severity of fibrin deposits observed postmortem in horses with severe gastrointestinal disorders. Animals: Antemortem hemostatic profile data and postmortem tissue samples (kidney, lung, liver) from 48 horses with colic. Methods: Tissue samples were stained with phosphotungstic acid hematoxylin and immunohistochemical methods for histological examination. A fibrin score (grades 0-4) was assigned for each technique, tissue and horse, as well as the presence or absence of DIC at postmortem examination. D-dimer concentration, prothrombin time (PT), activated partial thromboplastin time (aPTT), and antithrombin (AT) activity, as well as the clinicopathological evidence of coagulopathy, were determined from plasma samples collected 0-24 hours before death or euthanasia. Histologic and clinicopathologic data from the same horses were compared retrospectively. Results: No association was found between antemortem classification of coagulopathy and postmortem diagnosis of DIC based on tissue fibrin deposition. None of the hemostatic parameters was significantly different between horses with or without postmortem diagnosis of DIC. There was no association between horses with fibrin in tissues or different cut-offs for D-dimer concentration and postmortem evidence of DIC. Conclusions and Clinical Importance: Abnormalities of the routine clotting profile, including D-dimer concentration, were not useful in predicting histologic evidence of DIC at necropsy in horses with severe gastrointestinal disorders. 22016-01-0120162016-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/215646https://dx.doi.org/urn:doi:10.1111/jvim.13659reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2156462026-06-06T12:50:31Z
dc.title.none.fl_str_mv Association between necropsy evidence of disseminated intravascular coagulation and hemostatic variables before death in horses with colic
title Association between necropsy evidence of disseminated intravascular coagulation and hemostatic variables before death in horses with colic
spellingShingle Association between necropsy evidence of disseminated intravascular coagulation and hemostatic variables before death in horses with colic
Cesarini Latorre, Carlota
Cavalls
Malalties
Còlic en els cavalls
Coagulopathy
D-dimer
Equine
Thrombi
title_short Association between necropsy evidence of disseminated intravascular coagulation and hemostatic variables before death in horses with colic
title_full Association between necropsy evidence of disseminated intravascular coagulation and hemostatic variables before death in horses with colic
title_fullStr Association between necropsy evidence of disseminated intravascular coagulation and hemostatic variables before death in horses with colic
title_full_unstemmed Association between necropsy evidence of disseminated intravascular coagulation and hemostatic variables before death in horses with colic
title_sort Association between necropsy evidence of disseminated intravascular coagulation and hemostatic variables before death in horses with colic
dc.creator.none.fl_str_mv Cesarini Latorre, Carlota
Cotovio, M.
Ríos, José|||0000-0002-0716-8784
Armengou Ruiz, Lara|||0000-0003-4715-7323
José Cunilleras, Eduard|||0000-0002-4536-7717
author Cesarini Latorre, Carlota
author_facet Cesarini Latorre, Carlota
Cotovio, M.
Ríos, José|||0000-0002-0716-8784
Armengou Ruiz, Lara|||0000-0003-4715-7323
José Cunilleras, Eduard|||0000-0002-4536-7717
author_role author
author2 Cotovio, M.
Ríos, José|||0000-0002-0716-8784
Armengou Ruiz, Lara|||0000-0003-4715-7323
José Cunilleras, Eduard|||0000-0002-4536-7717
author2_role author
author
author
author
dc.subject.none.fl_str_mv Cavalls
Malalties
Còlic en els cavalls
Coagulopathy
D-dimer
Equine
Thrombi
topic Cavalls
Malalties
Còlic en els cavalls
Coagulopathy
D-dimer
Equine
Thrombi
description Background: Disseminated intravascular coagulation (DIC) is frequent in horses with severe gastrointestinal disorders. Postmortem studies have found fibrin microthrombi in tissues of these horses, but studies relating these histopathological findings with antemortem hemostatic data are lacking. Hypothesis: Antemortem classification of coagulopathy is related to the presence and severity of fibrin deposits observed postmortem in horses with severe gastrointestinal disorders. Animals: Antemortem hemostatic profile data and postmortem tissue samples (kidney, lung, liver) from 48 horses with colic. Methods: Tissue samples were stained with phosphotungstic acid hematoxylin and immunohistochemical methods for histological examination. A fibrin score (grades 0-4) was assigned for each technique, tissue and horse, as well as the presence or absence of DIC at postmortem examination. D-dimer concentration, prothrombin time (PT), activated partial thromboplastin time (aPTT), and antithrombin (AT) activity, as well as the clinicopathological evidence of coagulopathy, were determined from plasma samples collected 0-24 hours before death or euthanasia. Histologic and clinicopathologic data from the same horses were compared retrospectively. Results: No association was found between antemortem classification of coagulopathy and postmortem diagnosis of DIC based on tissue fibrin deposition. None of the hemostatic parameters was significantly different between horses with or without postmortem diagnosis of DIC. There was no association between horses with fibrin in tissues or different cut-offs for D-dimer concentration and postmortem evidence of DIC. Conclusions and Clinical Importance: Abnormalities of the routine clotting profile, including D-dimer concentration, were not useful in predicting histologic evidence of DIC at necropsy in horses with severe gastrointestinal disorders.
publishDate 2016
dc.date.none.fl_str_mv 2
2016-01-01
2016
2016-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/215646
https://dx.doi.org/urn:doi:10.1111/jvim.13659
url https://ddd.uab.cat/record/215646
https://dx.doi.org/urn:doi:10.1111/jvim.13659
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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