Epigenetic regulation of gfi1 in endocrine-related cancers: A role regulating tumor growth

Prostate and breast cancer constitute the most common cancers among men and women worldwide. The aging population is one of the main risk factors for prostate and breast cancer development and accumulating studies link aging with epigenetic changes. Growth factor independence-1 (Gfi1) is a transcrip...

Descripción completa

Detalles Bibliográficos
Autores: Ashour, Nadia, Angulo, Javier C., González-Corpas, Ana, Orea, María J., Lobo, María V.T., Colomer Bosch, Ramón, Colás, Begoña, Esteller, Manel, Ropero, Santiago
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/695512
Acceso en línea:http://hdl.handle.net/10486/695512
https://dx.doi.org/10.3390/ijms21134687
Access Level:acceso abierto
Palabra clave:Breast cancer
DNA methylation
Gfi1
Prostate cancer
Medicina
id ES_f3a9b3d5a2e84e908c7df06f935331b8
oai_identifier_str oai:repositorio.uam.es:10486/695512
network_acronym_str ES
network_name_str España
repository_id_str
spelling Epigenetic regulation of gfi1 in endocrine-related cancers: A role regulating tumor growthAshour, NadiaAngulo, Javier C.González-Corpas, AnaOrea, María J.Lobo, María V.T.Colomer Bosch, RamónColás, BegoñaEsteller, ManelRopero, SantiagoBreast cancerDNA methylationGfi1Prostate cancerMedicinaProstate and breast cancer constitute the most common cancers among men and women worldwide. The aging population is one of the main risk factors for prostate and breast cancer development and accumulating studies link aging with epigenetic changes. Growth factor independence-1 (Gfi1) is a transcriptional repressor with an important role in human malignancies, including leukemia, colorectal carcinoma, and lung cancer, but its role in prostate and breast cancer is unknown. We have found that Gfi1 epigenetic silencing is a common event in prostate and breast cancer. Gfi1 re-expression in prostate and breast cancer cell lines displaying Gfi1 epigenetic silencing decreases cell proliferation, reduced colony formation density, and tumor growth in nude mice xenografts. In addition, we found that Gfi1 repress alpha 1-anti-trypsin (AAT) and alpha 1-anti-chymotrypsin (ACT) expression, two genes with important functions in cancer development, suggesting that Gfi1 silencing promotes tumor growth by increasing AAT and ACT expression in our system. Finally, Gfi1 epigenetic silencing could be a promising biomarker for prostate cancer progression because it is associated with shorter disease-free survival. In conclusion, our findings strongly indicate that Gfi1 epigenetic silencing in prostate and breast cancer could be a crucial step in the development of these two-well characterized endocrine related tumors.This research was funded by Grants from the Fondo de Investigaciones Sanitarias, of the Instituto de Salud Carlos III (PI11/608 and PI16/594).MDPI, Basel, SwitzerlandDepartamento de MedicinaFacultad de Medicina20202020-06-30research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/695512https://dx.doi.org/10.3390/ijms21134687reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6955122026-06-23T12:46:27Z
dc.title.none.fl_str_mv Epigenetic regulation of gfi1 in endocrine-related cancers: A role regulating tumor growth
title Epigenetic regulation of gfi1 in endocrine-related cancers: A role regulating tumor growth
spellingShingle Epigenetic regulation of gfi1 in endocrine-related cancers: A role regulating tumor growth
Ashour, Nadia
Breast cancer
DNA methylation
Gfi1
Prostate cancer
Medicina
title_short Epigenetic regulation of gfi1 in endocrine-related cancers: A role regulating tumor growth
title_full Epigenetic regulation of gfi1 in endocrine-related cancers: A role regulating tumor growth
title_fullStr Epigenetic regulation of gfi1 in endocrine-related cancers: A role regulating tumor growth
title_full_unstemmed Epigenetic regulation of gfi1 in endocrine-related cancers: A role regulating tumor growth
title_sort Epigenetic regulation of gfi1 in endocrine-related cancers: A role regulating tumor growth
dc.creator.none.fl_str_mv Ashour, Nadia
Angulo, Javier C.
González-Corpas, Ana
Orea, María J.
Lobo, María V.T.
Colomer Bosch, Ramón
Colás, Begoña
Esteller, Manel
Ropero, Santiago
author Ashour, Nadia
author_facet Ashour, Nadia
Angulo, Javier C.
González-Corpas, Ana
Orea, María J.
Lobo, María V.T.
Colomer Bosch, Ramón
Colás, Begoña
Esteller, Manel
Ropero, Santiago
author_role author
author2 Angulo, Javier C.
González-Corpas, Ana
Orea, María J.
Lobo, María V.T.
Colomer Bosch, Ramón
Colás, Begoña
Esteller, Manel
Ropero, Santiago
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Medicina
Facultad de Medicina
dc.subject.none.fl_str_mv Breast cancer
DNA methylation
Gfi1
Prostate cancer
Medicina
topic Breast cancer
DNA methylation
Gfi1
Prostate cancer
Medicina
description Prostate and breast cancer constitute the most common cancers among men and women worldwide. The aging population is one of the main risk factors for prostate and breast cancer development and accumulating studies link aging with epigenetic changes. Growth factor independence-1 (Gfi1) is a transcriptional repressor with an important role in human malignancies, including leukemia, colorectal carcinoma, and lung cancer, but its role in prostate and breast cancer is unknown. We have found that Gfi1 epigenetic silencing is a common event in prostate and breast cancer. Gfi1 re-expression in prostate and breast cancer cell lines displaying Gfi1 epigenetic silencing decreases cell proliferation, reduced colony formation density, and tumor growth in nude mice xenografts. In addition, we found that Gfi1 repress alpha 1-anti-trypsin (AAT) and alpha 1-anti-chymotrypsin (ACT) expression, two genes with important functions in cancer development, suggesting that Gfi1 silencing promotes tumor growth by increasing AAT and ACT expression in our system. Finally, Gfi1 epigenetic silencing could be a promising biomarker for prostate cancer progression because it is associated with shorter disease-free survival. In conclusion, our findings strongly indicate that Gfi1 epigenetic silencing in prostate and breast cancer could be a crucial step in the development of these two-well characterized endocrine related tumors.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-06-30
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/695512
https://dx.doi.org/10.3390/ijms21134687
url http://hdl.handle.net/10486/695512
https://dx.doi.org/10.3390/ijms21134687
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI, Basel, Switzerland
publisher.none.fl_str_mv MDPI, Basel, Switzerland
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869424398770896896
score 15,300719

Similares en LA Referencia