The integrin-mediated adhesion complex: cooption of signaling systems at the dawn of Metazoa

The integrin-mediated adhesion machinery is the primary cell-matrix adhesion mechanism in Metazoa. The integrin adhesion complex, which modulates important aspects of the cell physiology, is composed of integrins (α and β subunits) and several scaffolding and signaling proteins. Integrins appeared t...

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Detalles Bibliográficos
Autores: Sebé Pedrós, Arnau, Ruiz Trillo, Iñaki
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/165679
Acceso en línea:https://hdl.handle.net/2445/165679
Access Level:acceso abierto
Palabra clave:Genòmica
Evolució (Biologia)
Metazous
Genomics
Evolution (Biology)
Metazoa
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spelling The integrin-mediated adhesion complex: cooption of signaling systems at the dawn of MetazoaSebé Pedrós, ArnauRuiz Trillo, IñakiGenòmicaEvolució (Biologia)MetazousGenomicsEvolution (Biology)MetazoaThe integrin-mediated adhesion machinery is the primary cell-matrix adhesion mechanism in Metazoa. The integrin adhesion complex, which modulates important aspects of the cell physiology, is composed of integrins (α and β subunits) and several scaffolding and signaling proteins. Integrins appeared to be absent in all non-metazoan eukaryotes so far analyzed, including fungi, plants, and choanoflagellates, the sister-group to Metazoa. Thus, integrins and, therefore, the integrin-mediated adhesion and signaling mechanism was considered a metazoan innovation. Recently, a broad comparative genomic analysis including new genome data from several unicellular organisms closely related to fungi and metazoans shattered previous views. The integrin adhesion and signaling complex is not specific to Metazoa, but rather it is present in apusozoans and holozoan protists. Thus, this important signaling and adhesion system predated the origin of Fungi and Metazoa, and was subsequently lost in fungi and choanoflagellates. This finding suggests that cooption played a more important role in the origin of Meta-zoa than previously believed. Here, we hypothesize that the integrin adhesome was ancestrally involved in signaling.Landes Bioscience2020202020102020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion3 p.application/pdfhttps://hdl.handle.net/2445/165679Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.4161/cib.3.5.12603Communicative & Integrative Biology, 2010, vol. 3, num. 5, p. 475-477https://doi.org/10.4161/cib.3.5.12603info:eu-repo/grantAgreement/EC/FP7/206883cc-by (c) Sebé Pedrós, Arnau et al., 2010http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1656792026-05-29T05:05:01Z
dc.title.none.fl_str_mv The integrin-mediated adhesion complex: cooption of signaling systems at the dawn of Metazoa
title The integrin-mediated adhesion complex: cooption of signaling systems at the dawn of Metazoa
spellingShingle The integrin-mediated adhesion complex: cooption of signaling systems at the dawn of Metazoa
Sebé Pedrós, Arnau
Genòmica
Evolució (Biologia)
Metazous
Genomics
Evolution (Biology)
Metazoa
title_short The integrin-mediated adhesion complex: cooption of signaling systems at the dawn of Metazoa
title_full The integrin-mediated adhesion complex: cooption of signaling systems at the dawn of Metazoa
title_fullStr The integrin-mediated adhesion complex: cooption of signaling systems at the dawn of Metazoa
title_full_unstemmed The integrin-mediated adhesion complex: cooption of signaling systems at the dawn of Metazoa
title_sort The integrin-mediated adhesion complex: cooption of signaling systems at the dawn of Metazoa
dc.creator.none.fl_str_mv Sebé Pedrós, Arnau
Ruiz Trillo, Iñaki
author Sebé Pedrós, Arnau
author_facet Sebé Pedrós, Arnau
Ruiz Trillo, Iñaki
author_role author
author2 Ruiz Trillo, Iñaki
author2_role author
dc.subject.none.fl_str_mv Genòmica
Evolució (Biologia)
Metazous
Genomics
Evolution (Biology)
Metazoa
topic Genòmica
Evolució (Biologia)
Metazous
Genomics
Evolution (Biology)
Metazoa
description The integrin-mediated adhesion machinery is the primary cell-matrix adhesion mechanism in Metazoa. The integrin adhesion complex, which modulates important aspects of the cell physiology, is composed of integrins (α and β subunits) and several scaffolding and signaling proteins. Integrins appeared to be absent in all non-metazoan eukaryotes so far analyzed, including fungi, plants, and choanoflagellates, the sister-group to Metazoa. Thus, integrins and, therefore, the integrin-mediated adhesion and signaling mechanism was considered a metazoan innovation. Recently, a broad comparative genomic analysis including new genome data from several unicellular organisms closely related to fungi and metazoans shattered previous views. The integrin adhesion and signaling complex is not specific to Metazoa, but rather it is present in apusozoans and holozoan protists. Thus, this important signaling and adhesion system predated the origin of Fungi and Metazoa, and was subsequently lost in fungi and choanoflagellates. This finding suggests that cooption played a more important role in the origin of Meta-zoa than previously believed. Here, we hypothesize that the integrin adhesome was ancestrally involved in signaling.
publishDate 2010
dc.date.none.fl_str_mv 2010
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/165679
url https://hdl.handle.net/2445/165679
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.4161/cib.3.5.12603
Communicative & Integrative Biology, 2010, vol. 3, num. 5, p. 475-477
https://doi.org/10.4161/cib.3.5.12603
info:eu-repo/grantAgreement/EC/FP7/206883
dc.rights.none.fl_str_mv cc-by (c) Sebé Pedrós, Arnau et al., 2010
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Sebé Pedrós, Arnau et al., 2010
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 3 p.
application/pdf
dc.publisher.none.fl_str_mv Landes Bioscience
publisher.none.fl_str_mv Landes Bioscience
dc.source.none.fl_str_mv Articles publicats en revistes (Genètica, Microbiologia i Estadística)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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