Breast Milk MicroRNAs Related to Leptin and Adiponectin Function Can Be Modulated by Maternal Diet and Influence Offspring Phenotype in Rats

There is evidence of the role of milk components in the metabolic programming of offspring. Here, we aimed to investigate the effects of a diet during lactation on breast milk leptin, adiponectin, and related miRNAs' expression, and their impact on dams and their offspring. Dams were fed a cont...

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Detalles Bibliográficos
Autores: Alonso-Bernáldez, Marta, Asensio, Antoni, Palou, Andreu, Sánchez, Juana, Serra, Francisca, Palou, Mariona
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/23394
Acceso en línea:https://hdl.handle.net/20.500.12105/23394
Access Level:acceso abierto
Palabra clave:Animales
Lactancia
Ratas
Fenómenos Fisiologicos Nutricionales Maternos
Leche
Fenotipo
Femenino
Leptina
Dieta
Adiponectina
MicroARNs
Phenotype
Milk
Diet
Maternal Nutritional Physiological Phenomena
MicroRNAs
Adiponectin
Leptin
Female
Rats
Animals
Lactation
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oai_identifier_str oai:repisalud.isciii.es:20.500.12105/23394
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repository_id_str
spelling Breast Milk MicroRNAs Related to Leptin and Adiponectin Function Can Be Modulated by Maternal Diet and Influence Offspring Phenotype in RatsAlonso-Bernáldez, MartaAsensio, AntoniPalou, AndreuSánchez, JuanaPalou, AndreuSerra, FranciscaPalou, MarionaAnimalesLactanciaRatasFenómenos Fisiologicos Nutricionales MaternosLecheFenotipoFemeninoLeptinaDietaAdiponectinaMicroARNsPhenotypeMilkDietMaternal Nutritional Physiological PhenomenaMicroRNAsAdiponectinLeptinFemaleRatsAnimalsLactationThere is evidence of the role of milk components in the metabolic programming of offspring. Here, we aimed to investigate the effects of a diet during lactation on breast milk leptin, adiponectin, and related miRNAs' expression, and their impact on dams and their offspring. Dams were fed a control diet (controls) or a diet enriched with oleic acid, betaine, and leucine (TX) throughout lactation. A TX diet promoted higher leptin at lactation day (LD) five and lower adiponectin on LD15 (vs. controls) in milk, resulting in increased leptin to adiponectin (L/A) ratio throughout lactation. Moreover, TX diet reduced milk levels of miR-27a, miR-103, miR-200a, and miR-222. Concerning TX offspring, higher body fat was early observed and maintained into adult life, accompanied by higher HOMA-IR than controls at three months of age. Offspring body fat content in adulthood correlated positively with milk L/A ratio at LD15 and negatively with miRNAs modulated by the TX diet. In conclusion, maternal diet during lactation can modulate leptin and adiponectin interplay with miRNAs in milk, setting up the metabolic programming of the offspring. Better knowledge about the influence of diet on this process is necessary to promote a healthy adult life in the progeny.Multidisciplinary Digital Publishing Institute (MDPI)20242024-10-0420222022-06-2920222022-06-29research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttps://hdl.handle.net/20.500.12105/23394reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/233942026-06-12T12:43:37Z
dc.title.none.fl_str_mv Breast Milk MicroRNAs Related to Leptin and Adiponectin Function Can Be Modulated by Maternal Diet and Influence Offspring Phenotype in Rats
title Breast Milk MicroRNAs Related to Leptin and Adiponectin Function Can Be Modulated by Maternal Diet and Influence Offspring Phenotype in Rats
spellingShingle Breast Milk MicroRNAs Related to Leptin and Adiponectin Function Can Be Modulated by Maternal Diet and Influence Offspring Phenotype in Rats
Alonso-Bernáldez, Marta
Animales
Lactancia
Ratas
Fenómenos Fisiologicos Nutricionales Maternos
Leche
Fenotipo
Femenino
Leptina
Dieta
Adiponectina
MicroARNs
Phenotype
Milk
Diet
Maternal Nutritional Physiological Phenomena
MicroRNAs
Adiponectin
Leptin
Female
Rats
Animals
Lactation
title_short Breast Milk MicroRNAs Related to Leptin and Adiponectin Function Can Be Modulated by Maternal Diet and Influence Offspring Phenotype in Rats
title_full Breast Milk MicroRNAs Related to Leptin and Adiponectin Function Can Be Modulated by Maternal Diet and Influence Offspring Phenotype in Rats
title_fullStr Breast Milk MicroRNAs Related to Leptin and Adiponectin Function Can Be Modulated by Maternal Diet and Influence Offspring Phenotype in Rats
title_full_unstemmed Breast Milk MicroRNAs Related to Leptin and Adiponectin Function Can Be Modulated by Maternal Diet and Influence Offspring Phenotype in Rats
title_sort Breast Milk MicroRNAs Related to Leptin and Adiponectin Function Can Be Modulated by Maternal Diet and Influence Offspring Phenotype in Rats
dc.creator.none.fl_str_mv Alonso-Bernáldez, Marta
Asensio, Antoni
Palou, Andreu
Sánchez, Juana
Palou, Andreu
Serra, Francisca
Palou, Mariona
author Alonso-Bernáldez, Marta
author_facet Alonso-Bernáldez, Marta
Asensio, Antoni
Palou, Andreu
Sánchez, Juana
Serra, Francisca
Palou, Mariona
author_role author
author2 Asensio, Antoni
Palou, Andreu
Sánchez, Juana
Serra, Francisca
Palou, Mariona
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Animales
Lactancia
Ratas
Fenómenos Fisiologicos Nutricionales Maternos
Leche
Fenotipo
Femenino
Leptina
Dieta
Adiponectina
MicroARNs
Phenotype
Milk
Diet
Maternal Nutritional Physiological Phenomena
MicroRNAs
Adiponectin
Leptin
Female
Rats
Animals
Lactation
topic Animales
Lactancia
Ratas
Fenómenos Fisiologicos Nutricionales Maternos
Leche
Fenotipo
Femenino
Leptina
Dieta
Adiponectina
MicroARNs
Phenotype
Milk
Diet
Maternal Nutritional Physiological Phenomena
MicroRNAs
Adiponectin
Leptin
Female
Rats
Animals
Lactation
description There is evidence of the role of milk components in the metabolic programming of offspring. Here, we aimed to investigate the effects of a diet during lactation on breast milk leptin, adiponectin, and related miRNAs' expression, and their impact on dams and their offspring. Dams were fed a control diet (controls) or a diet enriched with oleic acid, betaine, and leucine (TX) throughout lactation. A TX diet promoted higher leptin at lactation day (LD) five and lower adiponectin on LD15 (vs. controls) in milk, resulting in increased leptin to adiponectin (L/A) ratio throughout lactation. Moreover, TX diet reduced milk levels of miR-27a, miR-103, miR-200a, and miR-222. Concerning TX offspring, higher body fat was early observed and maintained into adult life, accompanied by higher HOMA-IR than controls at three months of age. Offspring body fat content in adulthood correlated positively with milk L/A ratio at LD15 and negatively with miRNAs modulated by the TX diet. In conclusion, maternal diet during lactation can modulate leptin and adiponectin interplay with miRNAs in milk, setting up the metabolic programming of the offspring. Better knowledge about the influence of diet on this process is necessary to promote a healthy adult life in the progeny.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-06-29
2022
2022-06-29
2024
2024-10-04
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12105/23394
url https://hdl.handle.net/20.500.12105/23394
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869424396448301056
score 15,812429

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