The Relevance of Oxidative Stress in the Pathogenesis and Therapy of Retinal Dystrophies

Retinal cell survival requires an equilibrium between oxygen, reactive oxygen species, and antioxidant molecules that counteract oxidative stress damage. Oxidative stress alters cell homeostasis and elicits a protective cell response, which is most relevant in photoreceptors and retinal ganglion cel...

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Detalles Bibliográficos
Autores: Domènech, Elena B., Marfany i Nadal, Gemma
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/196081
Acceso en línea:https://hdl.handle.net/2445/196081
Access Level:acceso abierto
Palabra clave:Estrès oxidatiu
Fotoreceptors
Retina
Glaucoma
Oxidative stress
Photoreceptors
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spelling The Relevance of Oxidative Stress in the Pathogenesis and Therapy of Retinal DystrophiesDomènech, Elena B.Marfany i Nadal, GemmaEstrès oxidatiuFotoreceptorsRetinaGlaucomaOxidative stressPhotoreceptorsRetinaGlaucomaRetinal cell survival requires an equilibrium between oxygen, reactive oxygen species, and antioxidant molecules that counteract oxidative stress damage. Oxidative stress alters cell homeostasis and elicits a protective cell response, which is most relevant in photoreceptors and retinal ganglion cells, neurons with a high metabolic rate that are continuously subject to light/oxidative stress insults. We analyze how the alteration of cellular endogenous pathways for protection against oxidative stress leads to retinal dysfunction in prevalent (age-related macular degeneration, glaucoma) as well as in rare genetic visual disorders (Retinitis pigmentosa, Leber hereditary optic neuropathy). We also highlight some of the key molecular actors and discuss potential therapies using antioxidants agents, modulators of gene expression and inducers of cytoprotective signaling pathways to treat damaging oxidative stress effects and ameliorate severe phenotypic symptoms in multifactorial and rare retinal dystrophies.MDPI2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/196081Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/antiox9040347Antioxidants, 2020, vol. 9, num. 4https://doi.org/10.3390/antiox9040347cc-by (c) Domènech, Elena B. et al., 2020https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1960812026-05-27T06:46:51Z
dc.title.none.fl_str_mv The Relevance of Oxidative Stress in the Pathogenesis and Therapy of Retinal Dystrophies
title The Relevance of Oxidative Stress in the Pathogenesis and Therapy of Retinal Dystrophies
spellingShingle The Relevance of Oxidative Stress in the Pathogenesis and Therapy of Retinal Dystrophies
Domènech, Elena B.
Estrès oxidatiu
Fotoreceptors
Retina
Glaucoma
Oxidative stress
Photoreceptors
Retina
Glaucoma
title_short The Relevance of Oxidative Stress in the Pathogenesis and Therapy of Retinal Dystrophies
title_full The Relevance of Oxidative Stress in the Pathogenesis and Therapy of Retinal Dystrophies
title_fullStr The Relevance of Oxidative Stress in the Pathogenesis and Therapy of Retinal Dystrophies
title_full_unstemmed The Relevance of Oxidative Stress in the Pathogenesis and Therapy of Retinal Dystrophies
title_sort The Relevance of Oxidative Stress in the Pathogenesis and Therapy of Retinal Dystrophies
dc.creator.none.fl_str_mv Domènech, Elena B.
Marfany i Nadal, Gemma
author Domènech, Elena B.
author_facet Domènech, Elena B.
Marfany i Nadal, Gemma
author_role author
author2 Marfany i Nadal, Gemma
author2_role author
dc.subject.none.fl_str_mv Estrès oxidatiu
Fotoreceptors
Retina
Glaucoma
Oxidative stress
Photoreceptors
Retina
Glaucoma
topic Estrès oxidatiu
Fotoreceptors
Retina
Glaucoma
Oxidative stress
Photoreceptors
Retina
Glaucoma
description Retinal cell survival requires an equilibrium between oxygen, reactive oxygen species, and antioxidant molecules that counteract oxidative stress damage. Oxidative stress alters cell homeostasis and elicits a protective cell response, which is most relevant in photoreceptors and retinal ganglion cells, neurons with a high metabolic rate that are continuously subject to light/oxidative stress insults. We analyze how the alteration of cellular endogenous pathways for protection against oxidative stress leads to retinal dysfunction in prevalent (age-related macular degeneration, glaucoma) as well as in rare genetic visual disorders (Retinitis pigmentosa, Leber hereditary optic neuropathy). We also highlight some of the key molecular actors and discuss potential therapies using antioxidants agents, modulators of gene expression and inducers of cytoprotective signaling pathways to treat damaging oxidative stress effects and ameliorate severe phenotypic symptoms in multifactorial and rare retinal dystrophies.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/196081
url https://hdl.handle.net/2445/196081
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/antiox9040347
Antioxidants, 2020, vol. 9, num. 4
https://doi.org/10.3390/antiox9040347
dc.rights.none.fl_str_mv cc-by (c) Domènech, Elena B. et al., 2020
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Domènech, Elena B. et al., 2020
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Genètica, Microbiologia i Estadística)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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