Cost-effectiveness of a community pharmacist intervention in patients with depression: a randomized controlled trial (PRODEFAR study)

Background: Non-adherence to antidepressants generates higher costs for the treatment of depression. Little is known about the cost-effectiveness of pharmacist's interventions aimed at improving adherence to antidepressants. The study aimed to evaluate the cost-effectiveness of a community phar...

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Autores: Rubio Valera, Maria, Bosmans, Judith, Fernández Sánchez, Ana, Peñarrubia María, María Teresa, March Pujol, Marian, Travé i Mercadé, Pere, Bellón, Juan A., Serrano Blanco, Antoni
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/46334
Acceso en línea:https://hdl.handle.net/2445/46334
Access Level:acceso abierto
Palabra clave:Atenció farmacèutica
Atenció primària
Depressió psíquica
Anàlisi cost-benefici
Assaigs clínics
Pharmacy practice
Primary health care
Mental depression
Cost effectiveness
Clinical trials
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spelling Cost-effectiveness of a community pharmacist intervention in patients with depression: a randomized controlled trial (PRODEFAR study)Rubio Valera, MariaBosmans, JudithFernández Sánchez, AnaPeñarrubia María, María TeresaMarch Pujol, MarianTravé i Mercadé, PereBellón, Juan A.Serrano Blanco, AntoniAtenció farmacèuticaAtenció primàriaDepressió psíquicaAnàlisi cost-beneficiAssaigs clínicsPharmacy practicePrimary health careMental depressionCost effectivenessClinical trialsBackground: Non-adherence to antidepressants generates higher costs for the treatment of depression. Little is known about the cost-effectiveness of pharmacist's interventions aimed at improving adherence to antidepressants. The study aimed to evaluate the cost-effectiveness of a community pharmacist intervention in comparison with usual care in depressed patients initiating treatment with antidepressants in primary care. Methods: Patients were recruited by general practitioners and randomized to community pharmacist intervention (87) that received an educational intervention and usual care (92). Adherence to antidepressants, clinical symptoms, Quality-Adjusted Life-Years (QALYs), use of healthcare services and productivity losses were measured at baseline, 3 and 6 months. Results: There were no significant differences between groups in costs or effects. From a societal perspective, the incremental cost-effectiveness ratio (ICER) for the community pharmacist intervention compared with usual care was 1,866 for extra adherent patient and 9,872 per extra QALY. In terms of remission of depressive symptoms, the usual care dominated the community pharmacist intervention. If willingness to pay (WTP) is 30,000 per extra adherent patient, remission of symptoms or QALYs, the probability of the community pharmacist intervention being cost-effective was 0.71, 0.46 and 0.75, respectively (societal perspective). From a healthcare perspective, the probability of the community pharmacist intervention being cost-effective in terms of adherence, QALYs and remission was of 0.71, 0.76 and 0.46, respectively, if WTP is 30,000. Conclusion: A brief community pharmacist intervention addressed to depressed patients initiating antidepressant treatment showed a probability of being cost-effective of 0.71 and 0.75 in terms of improvement of adherence and QALYs, respectively, when compared to usual care. Regular implementation of the community pharmacist intervention is not recommended.Public Library of Science (PLoS)2013201320132013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/46334Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0070588PLoS One, 2013, vol. 8, num. 8, p. 70588http://dx.doi.org/10.1371/journal.pone.0070588cc-by (c) Rubio Valera, Maria et al., 2013http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/463342026-05-29T05:05:01Z
dc.title.none.fl_str_mv Cost-effectiveness of a community pharmacist intervention in patients with depression: a randomized controlled trial (PRODEFAR study)
title Cost-effectiveness of a community pharmacist intervention in patients with depression: a randomized controlled trial (PRODEFAR study)
spellingShingle Cost-effectiveness of a community pharmacist intervention in patients with depression: a randomized controlled trial (PRODEFAR study)
Rubio Valera, Maria
Atenció farmacèutica
Atenció primària
Depressió psíquica
Anàlisi cost-benefici
Assaigs clínics
Pharmacy practice
Primary health care
Mental depression
Cost effectiveness
Clinical trials
title_short Cost-effectiveness of a community pharmacist intervention in patients with depression: a randomized controlled trial (PRODEFAR study)
title_full Cost-effectiveness of a community pharmacist intervention in patients with depression: a randomized controlled trial (PRODEFAR study)
title_fullStr Cost-effectiveness of a community pharmacist intervention in patients with depression: a randomized controlled trial (PRODEFAR study)
title_full_unstemmed Cost-effectiveness of a community pharmacist intervention in patients with depression: a randomized controlled trial (PRODEFAR study)
title_sort Cost-effectiveness of a community pharmacist intervention in patients with depression: a randomized controlled trial (PRODEFAR study)
dc.creator.none.fl_str_mv Rubio Valera, Maria
Bosmans, Judith
Fernández Sánchez, Ana
Peñarrubia María, María Teresa
March Pujol, Marian
Travé i Mercadé, Pere
Bellón, Juan A.
Serrano Blanco, Antoni
author Rubio Valera, Maria
author_facet Rubio Valera, Maria
Bosmans, Judith
Fernández Sánchez, Ana
Peñarrubia María, María Teresa
March Pujol, Marian
Travé i Mercadé, Pere
Bellón, Juan A.
Serrano Blanco, Antoni
author_role author
author2 Bosmans, Judith
Fernández Sánchez, Ana
Peñarrubia María, María Teresa
March Pujol, Marian
Travé i Mercadé, Pere
Bellón, Juan A.
Serrano Blanco, Antoni
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Atenció farmacèutica
Atenció primària
Depressió psíquica
Anàlisi cost-benefici
Assaigs clínics
Pharmacy practice
Primary health care
Mental depression
Cost effectiveness
Clinical trials
topic Atenció farmacèutica
Atenció primària
Depressió psíquica
Anàlisi cost-benefici
Assaigs clínics
Pharmacy practice
Primary health care
Mental depression
Cost effectiveness
Clinical trials
description Background: Non-adherence to antidepressants generates higher costs for the treatment of depression. Little is known about the cost-effectiveness of pharmacist's interventions aimed at improving adherence to antidepressants. The study aimed to evaluate the cost-effectiveness of a community pharmacist intervention in comparison with usual care in depressed patients initiating treatment with antidepressants in primary care. Methods: Patients were recruited by general practitioners and randomized to community pharmacist intervention (87) that received an educational intervention and usual care (92). Adherence to antidepressants, clinical symptoms, Quality-Adjusted Life-Years (QALYs), use of healthcare services and productivity losses were measured at baseline, 3 and 6 months. Results: There were no significant differences between groups in costs or effects. From a societal perspective, the incremental cost-effectiveness ratio (ICER) for the community pharmacist intervention compared with usual care was 1,866 for extra adherent patient and 9,872 per extra QALY. In terms of remission of depressive symptoms, the usual care dominated the community pharmacist intervention. If willingness to pay (WTP) is 30,000 per extra adherent patient, remission of symptoms or QALYs, the probability of the community pharmacist intervention being cost-effective was 0.71, 0.46 and 0.75, respectively (societal perspective). From a healthcare perspective, the probability of the community pharmacist intervention being cost-effective in terms of adherence, QALYs and remission was of 0.71, 0.76 and 0.46, respectively, if WTP is 30,000. Conclusion: A brief community pharmacist intervention addressed to depressed patients initiating antidepressant treatment showed a probability of being cost-effective of 0.71 and 0.75 in terms of improvement of adherence and QALYs, respectively, when compared to usual care. Regular implementation of the community pharmacist intervention is not recommended.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013
2013
2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/46334
url https://hdl.handle.net/2445/46334
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0070588
PLoS One, 2013, vol. 8, num. 8, p. 70588
http://dx.doi.org/10.1371/journal.pone.0070588
dc.rights.none.fl_str_mv cc-by (c) Rubio Valera, Maria et al., 2013
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Rubio Valera, Maria et al., 2013
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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