Abdominal obesity and dsyglycemia are risk factors for liver fibrosis progression in NAFLD subjects

To investigate longitudinal changes in the liver stiffness measurement (LSM) in the general adult population without known liver disease and to describe its association with metabolic risk factors, with a special focus on subjects with non-alcoholic fatty liver disease (NAFLD) and dysglycemia. A lon...

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Detalhes bibliográficos
Autores: Julián, María Teresa|||0000-0003-2524-1823, Ballesta Purroy, Sílvia|||0000-0001-8057-1804, Pera, Guillem|||0000-0003-3188-7268, Pérez-Montes de Oca, Alejandra|||0000-0001-8807-1935, Soldevila i Madorell, Berta|||0000-0002-4582-4201, Caballería, Llorenç|||0000-0002-7990-0719, Morillas Cunill, Rosa Ma|||0000-0001-9117-5049, Expósito, Carmen|||0000-0002-9246-3779, Martinez Escude, Alba|||0000-0003-0667-1609, Puig Domingo, Manuel|||0000-0002-6744-7195, Franch-Nadal, Josep|||0000-0002-5175-1555, Torán, Pere, Cusi, Kenneth|||0000-0002-8629-418X, Julve i Gil, Josep|||0000-0002-6531-2246, Mauricio, Didac|||0000-0002-2868-0250, Alonso Pedrol, Núria|||0000-0001-9687-8050
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:271602
Acesso em linha:https://ddd.uab.cat/record/271602
https://dx.doi.org/urn:doi:10.3389/fendo.2022.1051958
Access Level:acceso abierto
Palavra-chave:Liver fibrosis
NAFLD
Transient elastography
Abdominal obesity
Dysglycemia
General population
Descrição
Resumo:To investigate longitudinal changes in the liver stiffness measurement (LSM) in the general adult population without known liver disease and to describe its association with metabolic risk factors, with a special focus on subjects with non-alcoholic fatty liver disease (NAFLD) and dysglycemia. A longitudinal adult population-based cohort study was conducted in Catalonia. LSM was measured by transient elastography (TE) at baseline and follow-up (median: 4.2 years). Subgroup with NAFLD and dysglycemia were analyzed. Moderate-to-advanced liver fibrosis was defined as LSM ≥8.0 kPa and LSM ≥9.2 kPa respectively. Among 1.478 subjects evaluated, the cumulative incidence of LSM ≥8.0 kPa and ≥9.2 kPa at follow-up was 2.8% and 1.9%, respectively. This incidence was higher in NAFLD (7.1% for LSM ≥8.0 kPa and 5% for LSM ≥9.2 kPa) and dysglycemia (6.2% for LSM ≥8.0 kPa and 4.7% for LSM ≥9.2 kPa) subgroups. In the global cohort, the multivariate analyses showed that dysglycemia, abdominal obesity and atherogenic dyslipidemia were significantly associated with progression to moderate-to-advanced liver fibrosis. Female sex was negatively associated. In subjects with NAFLD, abdominal obesity and dysglycemia were associated with changes in LSM to ≥8.0 kPa and ≥9.2 kPa at follow-up. A decline in LSM value to <8 kPa was observed in 64% of those subjects with a baseline LSM ≥8.0 kPa. In this population study, the presence of abdominal obesity and dysglycemia were the main risk metabolic factors associated with moderate-to-advanced liver fibrosis development over time in general populations as well as in subjects with NAFLD.

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