Characterization of dissolved organic matter in wastewater using liquid chromatography-high resolution mass spectrometry
Individual hazardous chemicals and substance mixtures with synergistic toxicity ef-fects occur in the dissolved organic matter (DOM) of wastewater and negatively im-pact human health. Yet a large number of chemicals and their treatment by-products in wastewater makes the tracking of individual compo...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/667411 |
| Acceso en línea: | http://hdl.handle.net/10803/667411 |
| Access Level: | acceso abierto |
| Palabra clave: | Wastewater Aigües residuals Aguas residuales Micro-contaminants Microcontaminants Microcontaminantes Mass-spectrometry Espectrometria de masses Espectrometría de masas Non-targeted Anàlisi no dirigida Análisis no dirigido Liquid chromatography Cromatografia líquida Cromatografía líquida 54 628 |
| Sumario: | Individual hazardous chemicals and substance mixtures with synergistic toxicity ef-fects occur in the dissolved organic matter (DOM) of wastewater and negatively im-pact human health. Yet a large number of chemicals and their treatment by-products in wastewater makes the tracking of individual compounds nearly impossible and de-mands new analytical strategies. The thesis describes the development and evaluation of non-targeted and suspect anal-ysis methods aimed at the transformation of DOM and micro-contaminants of interest during wastewater treatment using liquid chromatography-high-resolution mass spec-trometry (LC-HRMS) data. On one hand, a non-targeted method to track transformations of DOM in a multiphase wastewater treatment using LC-HRMS data was developed. LC-MS signals were ex-tracted, aligned, and had their isotopologues clustered and elemental composition pre-dicted using open license software MZmine 2 in a way that conceptually prioritized the detection of anthropogenic compounds |
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