PRC1 is taking the lead in PcG repression

© 2015 The Authors. Polycomb group (PcG) proteins constitute a major epigenetic mechanism for gene repression throughout the plant life. For a long time, the PcG mechanism has been proposed to follow a hierarchical recruitment of PcG repressive complexes (PRCs) to target genes in which the binding o...

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Detalles Bibliográficos
Autores: Merini, Wiam, Calonje, Myriam
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2015
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/123078
Acceso en línea:http://hdl.handle.net/10261/123078
Access Level:acceso abierto
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spelling PRC1 is taking the lead in PcG repressionMerini, WiamCalonje, Myriam© 2015 The Authors. Polycomb group (PcG) proteins constitute a major epigenetic mechanism for gene repression throughout the plant life. For a long time, the PcG mechanism has been proposed to follow a hierarchical recruitment of PcG repressive complexes (PRCs) to target genes in which the binding of PRC2 and the incorporation of H3 lysine 27 trimethyl marks led to recruitment of PRC1, which in turn mediated H2A monoubiquitination. However, recent studies have turned this model upside-down by showing that PRC1 activity can be required for PRC2 recruitment and H3K27me3 marking. Here, we review the current knowledge on plant PRC1 composition and mechanisms of repression, as well as its role during plant development. Significance Statement Recent studies on PRC1 function challenge the classical hierarchical model for recruitment of PcG complexes to target genes to mediate gene repression in Arabidopsis by showing that the binding of PRC1 triggers the recruitment of PRC2 and H3K27 trimethylation.Peer ReviewedBlackwell PublishingConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2015201520152015info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/123078reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1230782026-05-22T06:33:51Z
dc.title.none.fl_str_mv PRC1 is taking the lead in PcG repression
title PRC1 is taking the lead in PcG repression
spellingShingle PRC1 is taking the lead in PcG repression
Merini, Wiam
title_short PRC1 is taking the lead in PcG repression
title_full PRC1 is taking the lead in PcG repression
title_fullStr PRC1 is taking the lead in PcG repression
title_full_unstemmed PRC1 is taking the lead in PcG repression
title_sort PRC1 is taking the lead in PcG repression
dc.creator.none.fl_str_mv Merini, Wiam
Calonje, Myriam
author Merini, Wiam
author_facet Merini, Wiam
Calonje, Myriam
author_role author
author2 Calonje, Myriam
author2_role author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description © 2015 The Authors. Polycomb group (PcG) proteins constitute a major epigenetic mechanism for gene repression throughout the plant life. For a long time, the PcG mechanism has been proposed to follow a hierarchical recruitment of PcG repressive complexes (PRCs) to target genes in which the binding of PRC2 and the incorporation of H3 lysine 27 trimethyl marks led to recruitment of PRC1, which in turn mediated H2A monoubiquitination. However, recent studies have turned this model upside-down by showing that PRC1 activity can be required for PRC2 recruitment and H3K27me3 marking. Here, we review the current knowledge on plant PRC1 composition and mechanisms of repression, as well as its role during plant development. Significance Statement Recent studies on PRC1 function challenge the classical hierarchical model for recruitment of PcG complexes to target genes to mediate gene repression in Arabidopsis by showing that the binding of PRC1 triggers the recruitment of PRC2 and H3K27 trimethylation.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/123078
url http://hdl.handle.net/10261/123078
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Blackwell Publishing
publisher.none.fl_str_mv Blackwell Publishing
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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